Excited to share our latest paper in @EurJImmunol! We found that anti-SARS-CoV-2 #IgA2, elevated in severe #COVID19, induces strong🔥 in #macrophages through FcαRI-Syk signaling & #immunometabolism. Huge thanks to coauthors & AI&I. @DrDenDunnen LynnMes 👉 https://t.co/oq7ivmtAgi

We already knew that severe acute #COVID19 is induced by pathogenic IgG. But now Lynn Mes & @oliverch77 show in @EurJImmunol that IgA2 adds even more fuel to the fire 🔥:

Injecting the blood of young mice into older mice reverses cognitive dysfunction and synaptic plasticity

Exposing mice to 11% oxygen (vs 21% normal) not only prevented Parkinson's symptoms but reversed motor dysfunction 6 weeks after onset.

Joining the Scientific #PostCOVID & #MECFS Symposium today at Vrije Universiteit Amsterdam. I’ll be sharing some of our work on immune imprinting in #LongCOVID done by Ashwin Mak. Huge thanks to @RobWust, Jelle, and @BraedenCharlton for putting together such a great program!

Honored to receive the Future of Science Fund Scholarship at the #KeystoneSymposia on #LongCOVID & Post-Acute Infection Syndromes. A truly inspiring meeting with new insights and collaborations! #KSLongCOVID26 #PASC #PAIS

DO‑HEALTH trial: Omega‑3, vitamin D and exercise slowed epigenetic clocks by ~3–4 months over 3 years in those over 70. And lowered invasive cancer risk by 61% https://t.co/TAVugIlTdO

Diagnosis and characterization of people with #MECFS (vs controls) using circulating cell-free RNA, indicative of immune system dysfunction and pro-inflammatory cytokine signaling https://t.co/x1sXG6zA9R

Chronic inflammation in Long COVID relationship to autoimmune diseases 🔥Reminder: Long COVID drives autoimmune diseases through chronic inflammation and immune dysregulation. ➡️Many studies have suggested that systemic chronic inflammation caused by residual viral components

Lactylation of XLF promotes non-homologous end-joining repair and chemoresistance in cancer https://t.co/d1NkBYiXz3

Thrilled to share I've been awarded the #Veni grant (€320k/3yrs) from #ZonMw/#NWO! My project investigates how antibodies rewire macrophage antiviral responses into inflammation, relevant to #COVID19, #LongCOVID, & #obesity. Huge thanks to mentors, colleagues & patients!

I had a great visit to Prague & thank the Czech authorities for their hospitality & ensuring my safety. The CCP’s unlawful activities will NOT intimidate me from voicing Taiwan’s interests in the international community. https://t.co/SXKBlgjMX4

This rate of validation suggests that affinity reagents such as antibodies should be considered non-specific until proven otherwise: 357 validated antibodies out of 1,124 tested. .

To restore the gut microbiome after antibiotics, the right diet (rich in carbohydrates, low in fat) was a better approach than fecal microbial transplants (in the experimental model) https://t.co/OJb9pTz2px https://t.co/Au5AT4nsSI

GLP-1-based therapies for diabetes, obesity and beyond https://t.co/JmGtGmwUTv This new review by @DanielJDrucker profiles GLP-1-based medicines, discussing optimization of pharmacokinetics and tolerability, engagement of new therapeutically useful pathways and safety aspects

Stanford researchers studied 24 patients and found Long COVID POTS involves widespread autonomic dysfunction including rapid heart rate, heightened adrenaline response, nerve damage, and signs of synuclein protein buildup linked to neurodegeneration. https://t.co/6kg2N3dZRa

Excited to share our latest study @ImmunityCP! Heartfelt thanks to the editorial and reviewer teams, my co-first @StephenTYeung, our co-authors and to @Kamal_M_Khanna for his outstanding mentorship throughout this journey! Pls read/RT!👇 https://t.co/HHfyP0VzRw

Kyoto University researchers reviewed data linking all seven known human coronaviruses to neurological damage. Finding is that some coronaviruses, especially SARS-CoV-2, may worsen or trigger neurodegenerative diseases by mimicking amyloid proteins. https://t.co/UwuaCjUPUb

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) can cause: - post-exertional malaise - soul-crushing fatigue - cognitive difficulties - sleep issues - sensitivities - pain - etc. A new NIH RECOVER study shows how surprisingly common it is for a SARS-CoV-2 infection

SARS-CoV-2 spike protein is a highly persistent, potentially pathogenic substance that may incite inflammation and tissue damage in almost all organ systems, resulting in #LongCovid a.k.a post-acute sequelae of Covid-19 (PAŚĆ) 1/