Greg Sepich-Poore
@multi_omics
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MD/PhD (Bioengineering) candidate. PhD in @KnightLabNews. Views my own.
Joined July 2016
It has been said that there are more microbes in the human body than there are stars in the galaxy✨. Discover the exciting role of the microbiome in cancer diagnostics in our latest Coffee Chat – register here >>> https://t.co/WeXl2x9CfX In association with @Micronoma
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Our work with the @CJohnstonLab1 lab out today @Nature demonstrating the intratumoral microbiota impacts spatial, cellular and transcriptional heterogeneity in human cancer. Monster tweetorial below from Chris.
Finally, two papers out within a day of each other from the @BullmanLab and @CJohnstonLab1 relating to the intratumoral microbiota, today in @Nature ( https://t.co/crU4Azm6Ck) and yesterday in @CellReports ( https://t.co/ESITlazD6h). 🧵below to those interested!
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Behind the scenes of my latest illustration, on the cover of this issue of @CellCellPress! 🍄✨ Honest disclaimer: my process videos almost never look this clean, this really was one of a kind! #sciart #scicomm #sciviz #sciencetwitter To know more ➡️ https://t.co/wX87pnmoQ8
Fantastic Fungi and where to find them 🍄 On the cover of @CellCellPress, @StraussmanR lab reports that fungi are present across all major human cancers and some "mycobiomes" can be predictive of clinical outcomes and therapy response. Congrats @liannarunsky &al @WeizmannScience!
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Differential Fungal Mycobiomes Exist between Tumor Types, a summary of the papers by @abdohlman, @IlievLab et al. and @LianNarunsky, @multi_omics, Ilana Livyatan, @KnightLabNews, @StraussmanR et al. https://t.co/fVOkGT4fMI
@DukeU @Cornell @WeizmannScience @UCSDMedSchool
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Microbial #cultures and shotgun/ITS #sequencing enabled two independent teams at @Cornell, @DukeU , @UCSDMedSchool and @WeizmannScience to confirm #fungal signatures associated with diverse #cancers. https://t.co/L9ooSLtvDh
genengnews.com
Two independent studies published in the same issue of the journal Cell, report overlapping evidence that establishes the association of specific fungal species with diverse human tumors. The...
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(5/5) Congrats also to @IlievLab for their independent research on the cancer mycobiome also published today in @CellCellPress! And thank you to @carlzimmer for writing a wonderful story about our work in The New York Times
nytimes.com
New research is revealing that cancer is rife with bacteria and fungi — a rich ecosystem that scientists call the tumor microbiome.
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(4/5) Congrats to @LianNarunsky and Ilana Livyatan, my co-first authors who helped championed this work, and to @KnightLabNews, @CMIdigest, @cameronmartino, @hyphaltip, @zhuqiyun, @ADSwafford, @PatelOncology, all other collaborators, and to @ucsd_mstp for the opportunity!
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(3/5) With @micronoma colleagues, we show that measuring bacterial and fungal DNA in the blood may help in the early detection of cancer, even in stage I disease, using TCGA blood samples and cell-free DNA data from independent researchers. Check out many other discoveries!
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(2/5) We found fungi in >17,000 samples across 35 cancer types demonstrating tumor type-specific fungal profiles. Fungi were mostly found within cancer and immune cells, and were associated with clinical features, including overall survival and immunotherapy response.
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(1/5) Did you know that there are bacteria in human tumors? Well, this is old news now 😉. Our new study, in collaboration with @StraussmanR+@TPilpel+@KnightLabNews, is featured on the cover of @CellCellPress, showing that human tumors contain fungi too! https://t.co/YHkIOTRbRn
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You might not believe it, but the following 6 machine learning books are fully free: - Deep Learning - Dive into Deep Learning - Machine Learning Engineering - Python Data Science Handbook - Probabilistic Machine Learning - Machine Learning Yearning Here are their links 🧵
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The latest TS Digest is now live! Read about how researchers are partnering with the public, the science of love, and more. https://t.co/kTT12r4fNd
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Excited to share our #BioEssays cancer microbiome paper on diagnostics and clonal evolution! Clonal evolution cannot remain a 'sterile' theory any longer, with genomic, transcriptomic, proteomic, and metabolomic microbial impacts on cancer cell fitness. https://t.co/zGmskug29B
onlinelibrary.wiley.com
Gut and intratumoral microbiomes comprise cancer's “second” genome and influence cancer biology. Cancer type and stage-specific tissue and blood-derived microbes enable microbially-informed cancer...
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As a part of this remarkable Review, authors illustrated evidence for some of the prominent tissue #microbiomes implicated in #cancer #hallmarks, beginning with the most prominent and evidently impactful microbiome, that of the intestinal tract. @CD_AACR
https://t.co/4F6JS1XJlx
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Just published! We proudly present "Hallmarks of Cancer: New Dimensions" by Douglas Hanahan, the third update to the seminal series. https://t.co/bSer4maIjF
@Ludwig_Cancer
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Proud to see my wife's first first-author paper posted on bioRxiv! Congrats, Caraline! https://t.co/0jroDIv6xz
biorxiv.org
Ribosomal RNAs (rRNAs) have long been known to carry modifications, including numerous sites of 2’ O -methylation and pseudouridylation, as well as N 6-methyladenosine (m6A), and N 6,6-dimethyladen...
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We built a framework to find optimal ages for cancer screening and surveillance based on models of clonal evolution - more to come! #mathonco #earlydetection
https://t.co/vDtMTyIocP
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A new #ScienceReview investigates research that shows how the bacteria, viruses and fungi of the microbiome are pervasive among human cancers, are key actors in #cancer immunotherapy, and are potentially engineerable to treat metastases. ($) https://t.co/4iTTd6Whhx
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How do bacteria and fungi play a role in #cancer physiology? Check out this new review from current @UCSanDiego Bioengineering student Greg Poore (@multi_omics) on the relationship between #cancer and the #microbiome
https://t.co/qbEh5BKNRz
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