Our work with the @CJohnstonLab1 lab out today @Nature demonstrating the intratumoral microbiota impacts spatial, cellular and transcriptional heterogeneity in human cancer. Monster tweetorial below from Chris.

New from the Bullman Lab in Cancer Cell! Tumor-infiltrating bacteria, including Fusobacterium, disrupt cell-cell contacts & trigger quiescence, uncovering a pathway of bacteria-induced therapy resistance 🔗 https://t.co/Bd3L6izEAl Thanks to @MDAndersonNews, @FredHutch, @UTEPnews

These findings add to the increasing evidence that cancer is not driven solely by DNA mutations. 🧵

I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13) https://t.co/Tr0nHLXRzz

Absolutely insane amount of data in this resource from @mason_lab The Spatial Atlas of Human Anatomy (SAHA): A Multimodal Subcellular-Resolution Reference Across Human Organs https://t.co/rwKWVtidfZ Spatial data on 15million cells from 100 donors across multiple ages, mainly GI

Stromal lipid species dictate melanoma metastasis and tropism https://t.co/2UlLo144Ze

Spatial Total RNA Sequencing of Formalin-Fixed Paraffin Embedded Tissues by spRandom-seq

Our team is hiring! 🦠 🧫 🥼🧑‍🔧

What exactly does "Fusobacterium nucleatum" refer to? It depends who you ask (and when you asked them). Our new perspective on taxonomy and naming challenges @GutMicrobes, proposing a genomics-based framework for Fusobacterium species designations. 🦠

If your stack of images is full of defects, don't panic! InterpolaAI, a deep learning-based optical flow method, will fix issue tears, photobleaching and sticking artifacts for improved 3D imaging. Read our paper in Nature Methods: https://t.co/LIpzl3heoB

Second paper on HMGA2 mediated basal identity in #PancreaticCancer from Sita Kugel @fredhutch. This one is an elegant mechanistic dissection of the multi step cascade through which HMGA2 overexpression orchestrates basal lineage state: https://t.co/vUgXCW6vNL

Powerful new story from the Srivastava Lab @sriv4000

Looking forward to presenting and hearing from the other speakers this evening @AACR25, at the microbiota and cancer prevention, diagnosis, and treatment session! Room S105 @MDAndersonNews

Thrilled to share our latest study just out in @Nature 😄A major milestone in our collaboration with ⁦@Aiims1742⁩ Led by brilliant ⁦⁦⁦@GuangshengPei⁩ ⁦⁦⁦⁦⁦⁦⁦⁦⁦⁦⁦@jiminmin_v⁩ ⁦⁦@MDAndersonNews⁩

Wonderful work @IamLinghua, @Aiims1742 and team! 👏

It was a quite a transformative experience to attend the inaugural Microbiome Accelerator from NatureAwards and @seedhealth in London last year. Highly recommend entrepreneurial microbiome scientists to apply for the 2025 cycle!

1/ Out today in @Cancer_Cell our work on spatial subtypes and cellular neighborhoods of cancer-associated fibroblasts (CAFs)! Led by the brilliant @liuyunho with key contributions from @Aiims1742 @humam_kadara and many collaborators @MDAndersonNews

Beautiful work on Fusobacterium and CRC by @JessicaRQueen1, Drewes & Sears teams. “Biofilms were prevalent on colon tumors visualized in 68.8% ….more frequently observed on right-sided tumors (91.7%)”. https://t.co/UjQyFXfaAF

Published on Christmas day 🎁, our (@mzepedar & @BullmanLab) final paper of 2024 "Fusobacterium sphaericum sp. nov., isolated from a human colon tumor adheres to colonic epithelial cells and induces IL-8 secretion" https://t.co/wgB7Xj3bWq

1/ Congrats to Sunita Keshari and all authors on our publication, where we interrogated tumor microenvironment (TME) remodeling induced by neoantigen (NeoAg) cancer vaccines and αPD-1, αCTLA-4 ICT, uncovering a more effective NeoAg vaccine-based combo preclinical therapy.

Four years after the 2020 Method of the Year (“spatially resolved transcriptomics”), @naturemethods has now nominated “spatial proteomics” as the 2024 Method of the Year. H/T @RongFan8 (spatial guru!)