Christos Constantinidis
@c_constan
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Professor of Biomedical Engineering and Neuroscience. Neural basis of cognition, cognitive development, deep brain stimulation.
Nashville, USA
Joined October 2010
New review article: Timescales of learning in prefrontal cortex https://t.co/IcbzYOGmVJ
nature.com
Nature Reviews Neuroscience - The prefrontal cortex is critical for working memory, over a timescale of seconds. In this Review, Miller and Constantinidis examine how the prefrontal cortex...
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🏆 Nominations are open for the 2026 Huttenlocher Award! Help us celebrate pioneering research in Developmental Cognitive Neuroscience Follow the link below to learn more and submit your nomination today! 🔗 https://t.co/xI0ev6nT32
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Was that the most pointless government shutdown in history?
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Longitudinal measures of monkey brain structure and activity through adolescence predict cognitive maturation @c_constan
https://t.co/mpWNVI6NZj
nature.com
Nature Neuroscience - Working memory improves during adolescent brain development. Zhu et al. tracked monkeys through adolescence, revealing that maturation of white matter tracts and refinement of...
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MaskGraphene: an advanced framework for interpretable joint representation for multi-slice, multi-condition spatial transcriptomics https://t.co/N3cwG2DIms
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Ok Mamdani won. Can we now reopen the government, please?
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Many thanks to the interdisciplinary team that made this study possible - and to my trainees @JundaZhu and Clement Garin who saw it to completion (10/10)
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Because rhesus macaque brain development parallels human trajectories, these findings illuminate mechanisms of adolescent cognition and why connectivity disruptions may underlie psychiatric risk (9/10)
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Long-distance tracts, including the superior fronto-occipital fasciculus and anterior cingulum, best predicted working memory precision and speed (8/10)
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Unlike prior emphasis on gray matter thinning (e.g. due to pruning of unwanted synapses), our study shows cortical volume & thickness poorly predict cognitive maturation. White matter maturation was the key driver (7/10)
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Prefrontal neuron firing rate generally increased through adolescence, while variability declined, and dimensionality of responses increased, supporting flexible coding and distractor resistance (6/10)
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Tracking monkeys from late childhood to adulthood, we combined behavior, MRI, and single-neuron recordings. Our overarching result was that working memory improved as frontal lobe structural connectivity strengthened. (5/10)
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However the brain alterations responsible for the changes in neural firing rate, which is ultimately altering the maturing cognitive functions, have remained elusive (4/10)
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It has been well known that improvement of cognitive performance in adolescence coincides with a number of structural changes in the brain, including volume and surface of the prefrontal cortex and maturation of white matter tracts (3/10)
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The prefrontal cortex, a brain area critical for executive functioning, has not reached its fully mature state yet in adolescence. Impulsivity, poor decision-making, sensation seeking are hallmarks of adolescent behavior (2/10)
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New paper from the lab: Longitudinal measures of monkey brain structure and activity through adolescence predict cognitive maturation A brief thread (1/10) https://t.co/5jpHXlHmXs
nature.com
Nature Neuroscience - Working memory improves during adolescent brain development. Zhu et al. tracked monkeys through adolescence, revealing that maturation of white matter tracts and refinement of...
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The metricization of science is the death of science. Any scientist "welcomes this initiative" should be permanently disbarred. https://t.co/hvJBxAeaCP
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