Mark Andermann
@andermann_mark
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What triggers anorexia nervosa? We find that chronic stress can trigger willful seeking of a starvation-like state in mice. As in humans, this was enriched in female mice, particularly those predisposed to stress.
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My daughter: What are you working on?
Me: Proofs for a paper..
My daughter: Awwww. You’re listed last. Does that mean you worked on it the least?
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Excited to share new work from Arthur Sugden and colleagues in
@NatureNeuro
using two-photon calcium imaging in visual association cortex to examine offline reactivations of recent sensory experiences during cue-reward learning. More in THREAD … 1/4.
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Different retinal axon classes were more strongly suppressed by serotonin release or pupil-linked arousal, indicating specific gating of visual info streams before they activate thalamocortical neurons. Congrats to Jasmine Reggiani!
@NeuroCellPress
.
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In Current Biology today:
By tracking visual association cortex neurons over weeks across learning, we found learning-related neurons that encode cues in specific conjunctions of reward and locomotor contexts. (1/3)
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Stress can trigger willful seeking of a starvation-like state in certain female mice predisposed to higher anxiety. Now published and downloadable here:
Congrats to lead-author
@haganK
,
@Oren_Amsalem
,
@andrewlutas
, and the whole team.
Feedback welcome!
What triggers anorexia nervosa? We find that chronic stress can trigger willful seeking of a starvation-like state in mice. As in humans, this was enriched in female mice, particularly those predisposed to stress.
1/7
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Couldn't be more excited for
@NghiaDNguyen
. I think he uncovered something really exciting. Congrats to the entire team!
Amazing day for my first tweet. Super excited to share my PhD research, published today
@Nature
.
We find that contrary to popular belief, cortical reactivations predict the future rather than reflect the past.
1/10
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How do peptides and biochemical signals give rise to neural computations in the intact brain? Stephen Zhang and a wonderful team found that multiple stochastically released neuropeptides compete to control biochemical signaling, thereby regulating plasticity rates and behavior.
I am excited to share our preprint on how hypothalamic hunger- and satiety-promoting neuropeptides compete at the level of cAMP to regulate feeding. We imaged endogenous peptide signals in subcellular compartments during behavior. Below are the findings:
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(1/4) Excited to share Kelly McGuire’s thesis work imaging 1000's of neurons across 10's of days throughout associational learning and reversal learning:
Visual association cortex links cues with conjunctions of reward and locomotor contexts
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Excited to share Nghia Nguyen’s graduate work
@biorxiv_neursci
!
How do offline stimulus reactivations in cortex relate to later changes in stimulus responses (representational drift)?
Cortical reactivations predict future sensory responses.
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Neuromodulators and peptides act on Gs-coupled receptors to increase cAMP. We found that brief photostimulation of cAMP production in parabrachial nucleus neurons drives spiking for tens of seconds. This process may mediate sustained feeding suppression following a brief threat.
Brief stimuli can lead to long-lasting behavioral changes, so how do neurons transform a short-lived stimulus into a long-lasting change?
In our preprint, we show that cAMP could be a part of the answer by directly influencing neuronal activity!
👇🧵
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Tracking biochemical signaling in the amygdala in vivo to try to link neuromodulation with learning. This approach highlights aspects of cellular dynamics that may be less apparent in recordings of electrical activity. Congrats to Andrew Lutas
@andrewlutas
and the whole team!
In a continuing effort to understand how animals learn which events are salient, we investigated the dopamine to cAMP transformation that occurs during associative plasticity in the basal amygdala. We appreciate any feedback.
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Most studies characterize visual cortical neurons using stimulus-triggered responses, but the picture is quite different when you trigger on internally generated events such as hippocampal ripples.
Really fun collaboration with
@HuijeongJeong
, Min Whan Jung, and
@vijay_mkn
!
Have you wondered what the brain does while you’re daydreaming without sensory arousal? We found distinct neuronal ensembles distributed across 6 visual cortices that couple to ripples in either dorsal or intermediate hippocampus during these epochs. 1/16
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Working with Stephen Zhang and colleagues on this project was a joy, a privilege, and a tonic during a difficult period. Any feedback would be very welcome!
I am excited to share our new paper on mating drive! We found dopamine neurons in the hypothalamus that control the motivation to mate in male mice, and these dopamine neurons signal through persistent cAMP elevations in the downstream circuitry.
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We modeled migraine using cortical spreading depolarization in collab w/ Dan Levy’s lab. We suggest that enhanced responsiveness of meningeal afferents to local meningeal deformation is a key substrate underlying the worsening of migraine headache pain during physical activity.
How cortical spreading depolarization (CSD) affects meningeal afferents to drive migraine headache? Our new afferent imaging study in awake mice implicates acute calcium response and prolonged sensitization to locomotion-related meningeal deformation.
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Our lab is hoping to hire a research technician with neuroscience experience to join a new project examining awareness and anticipation of body signals. The ideal candidate would have experience with stereotaxic surgery and acquisition/analysis of neural data.
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This new work, led by Andrew Lutas
@andrewlutas
with help from
@kayla_fernando
,
@StephenXZhang
, and Abhi Sambangi, will hopefully open up many avenues of research in the Lutas lab and beyond. Congrats!
History-dependent dopamine release increases cAMP levels in most basal amygdala glutamatergic neurons to control learning
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In an effort led by
@Yoav_Livneh
, we review recent studies recording and manipulating cellular activity in rodent insular cortex. We suggest that predictive processing of future bodily states may provide a unifying framework for interpreting these findings. Feedback is welcome!
Our insula review is out in
@NeuroCellPress
!!!
@andermann_mark
and I review recent studies recording and manipulating cellular activity in rodent insula at timescales from seconds to hours. Inspired by theoretical and CogNeuro studies,...(1/2)
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Sr. Research Associate position open! >4 yr commitment. Prereqs: science nerd, kind, respectful, assertive, organized, >5 yrs experience post-BSc. Will train/oversee undergrads/technicians, manage mouse colony, equipment, orders, reimbursements, protocols.
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Collaboration is key to scientific progress. Congrats to Fred Shipley, Neil Dani, Maria Lehtinen and an amazing multi-lab team of choroid plexus explorers. Come for the pictures, stay for the movies.
Investigating the choroid plexus has been limited by a lack of tools for in vivo visualization & manipulation. A stunning effort led by recent PhD Fred Shipley
@FreshDipley
and out today in
@NeuroCellPress
showcases a new suite of techniques to fix that!
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New Dispatch from
@McGinleyLab
() on studies of arousal-related modulation of activity in retinal axons from
@liangl02
and team (Chen/Andermann labs; published today: ) and from
@sylvia_schroed
,
@MatteoCarandini
and colleagues.
Happy to announce that our article 'Retinal Inputs to the Thalamus Are Selectively Gated by Arousal' is online today in Current Biology
Kudos to our reviewers, editors, and all the coauthors
@AlexFratzl
@jazz_regg
, Omar,
@ChinfeiC
@andermann_mark
!!
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Exciting work defining the blood-CSF barrier. Great to finally see this in print!
The choroid plexus blood-CSF barrier has remained a mystery for far too long! Our study led by
@NeilCDani1
and Rebecca Herbst, w/ Aviv Regev &
@naomi_habib
, is out today in
@CellCellPress
showcasing a cell atlas & exciting new findings. 1/11
Read it here
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Any attempt to apply knowledge from basic neuroscience to understand psychiatric illness requires extreme determination and risk tolerance. This was a truly amazing effort from lead-author Hakan Kucukdereli (
@haganK
) together with
@Oren_Amsalem
and the rest of the team!
7/7
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Meningeal afferents are involved in interoceptive sensing of mechanical deformations in the awake mouse brain during locomotion! A great collaboration with Dan Levy's group (
@DanLevy919
).
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Our lab is hoping to hire a Research Associate / Lab Manager with a positive attitude and 3+ years of postbac experience working with mice, including colony maintenance. Brain surgery / histology experience a plus. For more info, see:
Please RT! Thanks.
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The Division of Endocrinology, Diabetes and Metabolism at BIDMC is starting a faculty search. If you know of any promising candidates, please forward them the link below. Thanks!
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Super exciting work!
Do immune cells enter the inflamed adult brain via the choroid plexus (ChP)?🤒 Our
@biorxivpreprint
led by
@Huixin_BJ
shows leukocytes crossing the ChP in real time & reveals molecular mechanisms w/ scRNAseq master
@plotfy33
. 1/
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This was a strong effort led by (now Dr.) Kelly McGuire, co-mentored by Christian Burgess (
@helixCB
) who helped start this project. Thanks also to Oren Amsalem (
@Oren_Amsalem
), Arthur Sugden, Rohan Ramesh, and Jesseba Fernando. Data are here:
(3/3)
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We propose that different flavors of reactivation of previous cue presentations may selectively strengthen relevant ensembles of neurons encoding both the cue and the associated reward, while weakening intermingled ensembles of putatively task-irrelevant neurons … 4/4
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Our division is hiring at the Assistant Professor level. If you thing it might be a good fit, please apply!
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Elevated anxiety often precedes anorexia nervosa. Patients with anorexia nervosa often describe hunger as pleasant, potentially because food restriction can be anxiolytic. We tested whether chronic stress can cause animals to prefer a starvation-like state.
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Prior to stress induction, male but not female mice showed mild aversion to AgRP stimulation. Strikingly, following chronic stress, a subset of females developed a strong preference for AgRP stimulation that was predicted by high baseline anxiety.
4/7
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@HuijeongJeong
Most studies characterize visual cortical neurons using stimulus-triggered responses, but the picture is quite different when you trigger on internally generated events such as hippocampal ripples. Really fun collaboration with
@HuijeongJeong
, Min Whan Jung, and
@vijay_mkn
!
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The same patterns of neurons driven by specific visual cues were subsequently reactivated during quiet waking in darkness, with higher reactivation rates during early learning and for food-predicting vs. neutral cues … 2/4.
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We then developed a novel, model-free deep learning method for classifying facial expressions. We found that stress-induced changes in preference were reflected in changes in facial expressions during AgRP stimulation.
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We developed a virtual reality place preference paradigm in which head-fixed mice can voluntarily seek a starvation-like state induced by optogenetic stimulation of hypothalamic agouti-related peptide (AgRP) neurons.
3/7
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We also found Adapting neurons that respond to visual stimuli prior to training and are insensitive to reward context. Further, the average visual cue response, pooled across all neurons, was remarkably stable over stages of learning. (2/3)
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Congrats to
@jazz_regg
and amazing collaborators
@ChinfeiC
, Qiufen Jiang,
@melaniebb12
,
@andrewlutas
,
@liangl02
,
@richlyn_jesseba
, Fei Deng , Jinxia Wan ,
@yulonglilab
. Thanks to the
@NatEyeInstitute
for believing in the project.
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(4/4) Our study of association cortex builds on work in connected areas including the hippocampal formation, amygdala, and sensory cortex.
Any feedback would be very welcome!
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Reactivations involving ensembles of neurons encoding both the food cue and the reward predicted strengthening of next-day functional connectivity of participating neurons, while the converse was observed for reactivations involving ensembles encoding only the food cue … 3/4
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We thank The Klarman Family Foundation for their guidance, support, and encouragement to connect with clinician-scientists, as well as the Brain & Behavior Research Foundation, the Davis Foundation, McKnight Foundation, and the NIH.
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Using optogenetic stimulation of dorsal raphe axons in the thalamus, we find that serotonin suppresses activity-dependent presynaptic calcium and glutamate release from retinal axon terminals.
2/5
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Using two-photon calcium imaging of individual retinal axon terminals, we find that suppression was greater in boutons with stronger responses to global luminance changes vs. local contrast. Pupil-linked arousal suppresses a distinct set of retinal information channels.
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Really proud of you, Fred!
Congratulations to our very own Doctor Fred Shipley
@freshdipley
!!! He led a successful thesis defense yesterday, taking us through his incredibly productive and collaborative journey
@andermann_mark
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Congrats to
@haganK
and thanks to
@Oren_Amsalem
,
@andrewlutas
and other co-authors, who found that stress can trigger willful seeking of a starvation-like state in certain female mice predisposed to higher anxiety. Now published!
$
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Using electrophysiology, immunohistochemistry and analysis of publicly available scSeq data, we suggest that selectivity in serotonin suppression of retinal channels is due to differences in expression of presynaptic 5-HT1B receptors.
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(2/4) We found that mouse postrhinal cortex contains intermingled groups of neurons that encode sensory cues either independent of context or in specific conjunctions of contexts (i.e., only during locomotion or when stationary, and only when the cue is rewarded or unrewarded).
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(3/4) Despite the diversity in neurons' response dynamics across stages of learning and relearning, average visual responses across the entire population were remarkably balanced at each stage of learning.
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We suggest that activity patterns during sensory cortical reactivations may reside on a manifold and may actively guide (rather than consolidate) the drift in sensory responses towards this manifold to improve sensory discrimination.
5/6
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To greatly increase SNR when tracking reactivations, Nghia imaged from ~6,600 neurons simultaneously in lateral visual cortex as mice passively viewed two distinct visual stimuli for hours, each followed by a 1-minute ITI where reactivations occurred during quiet waking.
2/6
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51 graduate students and their advisers are joining the thriving community supported by the HHMI Gilliam Fellowships for Advanced Study.:
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Congrats to
@andrewlutas
,
@Jonna_Singh_
, Joseph Madara, Jeremiah Isaac, and Caroline Lommer for their strong collaborative effort!
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Contrary to prevailing theories suggesting that reactivations only reflect past experiences, Nghia found that cortical reactivations (R1, R2) of two stimuli (S1, S2) were more similar to future patterns evoked by the stimuli hours later.
3/6
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@LehtinenLab
@HarvardGSAS
@HarvardGSC
@mezawadzki
@ScienceYael
@EbbtheScientist
@wheremytiara_at
Congratulations Maria!
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Congrats to
@NghiaDNguyen
and amazing collaborators
@andrewlutas
,
@richlyn_jesseba
,
@SVergaraCobos
,
@JustinMcMahon_
, and
@JDimidschstein
! Thanks also to the Andermann lab and many others for feedback.
Thoughts welcome!
6/6
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The rate and content of reactivations was sufficient to accurately predict future changes in stimulus response patterns.
4/6
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Fascinating talk.
New Broad talk: Yonatan Grad (
@yhgrad
) presents "Navigating the
#COVID19
pandemic: from life raft to dry land."
Watch:
@HarvardChanSPH
#coronavirus
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