A previously unrecognized estrogen-dependent signaling pathway in the gut regulates visceral pain sensitivity in mice, according to a new Science study. The findings provide a pathway toward targeted therapeutic strategies. 📄: https://t.co/KANGJGjCt4 #SciencePerspective:

Cancer cell plasticity and resistance to KRAS inhibition Two recent preclinical examples in #ColorectalCancer @CD_AACR https://t.co/ydxGI93QMe @Cancer_Cell https://t.co/DG7HXUlipn

🔥off the press🔥 Cholangiocarcinoma 2026: status quo, unmet needs and priorities @NatRevGastroHep https://t.co/bG6kCL3DSU 👉get the lastest, most comprehensive summary on cholangiocarcinoma 👏fantastic team effort! @myESMO @EASLedu @ILCAnews

How can a gene mutation be present throughout the body yet cause cancer only in certain tissues? This is exactly the challenge our SPECIFICANCER team took on 7 years ago. Read the newly published impact report from the team that reshaped our understanding of tissue specificity

Systemic review on neurocognitive outcomes in patients with🧠 metastases in @TheLancetOncol Urgent need for research assessing modality-specific neurocognitive tox and optimal sequencing of therapies! @OncoAlert #brainmets https://t.co/4ZocYIuxmi

What’s true in #PancreaticCancer precursor lesions is also true in #ColorectalCancer precursor lesions. @cncurtis @SnyderShot @StanfordMed demonstrate polyclonal origin of adenomas in patients with FAP. Cancer as a manifestation of convergent evolution! https://t.co/Bnqko2Z2Y8

Groundbreaking work just came today from  @owen_sansom Lab, spearheaded by Mark White and exceptionally talented team @CRUKScotland & @UoFGlasgow The work unmasked MAPK-driven Colorectal Cancer's clever escape from therapy. Yes Always search for the WNT.  https://t.co/MjJErUh8Yz

Very proud of all our hardwork! Exciting new paper exploring the origin of liver cancer https://t.co/bmmXgNlzFI @owen_sansom

Paneth-like transition drives resistance to dual targeting of KRAS & EGFR in CRC ✅CRC cells surviving combined KRAS & EGFR inhibition acquire Paneth-like state ✅SMAD1-FGFR3 axis triggers Paneth-like plasticity ✅FGFR3 blockade could overcome plasticity-driven drug tolerance

Provocative new data in @NatureMedicine from @JenWargoMD @nadim_ajami & colleagues @MDAndersonNews Microbial signals in primary and metastatic brain tumors https://t.co/6htdGy7vPt Orthogonal validation using multiple platforms provides support for this observation

📌Inaccurate lymph node clinical staging in early and intermediate-risk rectal cancer @EORTC 🚨19.5% understaged and 62.4% overstaged ✅Seems no survival effect ➡️At least a destressing data when MRI shows 1-3 small lymph nodes that we can not decide whether pathologic or not

ANOVA in R! 💪 in ONE LINE OF CODE! ggstatsplot::ggbetweenstats(ISLR::Wage, race, wage) Watch the video for more details: https://t.co/pvjcai0see #rstats #statistics #dataanalysis #stats #datascience #r4ds

🍽️ Turning “no appetite” into “pass the plate” with olanzapine 📝 JNCCN 2025 | OlAnCa trial | DB RCT | n=164 | Cairo Univ 🔑 Trial essentials • 🌐 Incurable solid tumors + cachexia • 🎲 Randomized: Olanzapine 5 mg QHS vs placebo • 🎯 Primary: Appetite (ESAS-Anorexia) @ 1 wk

#USCAP2025 w/ Dr Voltaggio Esophageal ⬆️ grade dysplasia/intramucosal adeno → treated with EMR. Presence of muscularis mucosa = lateral margin; large vessels + loose CT = deep margin. Recommendation to pin specimen before fixing for easier margin assessment. #PathWebinarPearls

New review: Mellor, Larson, and @DrMengWang discuss the molecular mechanisms of mammalian genomic instability arising from folate deficiency and how this impacts genome biology in health and disease. https://t.co/drz4rp0yqn #CellMetabolism

New Paper Alert: BRCA1/2 Mutations and RB1 Alterations Predict Poorer Outcomes With Endocrine Therapy ± CDK4/6 Inhibitors in HR+/HER2– Breast Cancer Authors: Hamdy A. Azim, Hagar Elghazawy (@HagarElghazawy1), Kyrillus S. Shohdy (@Kyrillus2 ) Shaimaa Lasheen, Mahmoud Elghazawy,

Here is a video on management of 4 common lower GI radiotherapy toxicities: 1. Radiation dermatitis 2. Diarrhea 3. Acute RT proctitis 4. Late/chronic RT proctitis Hope it is helpful! Full video (16 min) & slides 🧵 thread below. 1/X

Olanzapine for Anorexia in Patients With Incurable #Cancer and #Cachexia (OlAnCa): A Double-Blind, Placebo-Controlled, Randomized Clinical Trial. https://t.co/0rOzyCvthm @JNCCN @CancerCachexia #CancerResearch #PallOnc #SuppOnc #CancerCare

Our study is out @ESMO_Open. The largest cohort from Northern African background on BRCA1/2 genetics. So pleased to lead such work that bridges the equity gap in precision oncology.

We are recruiting a Senior Scientific Officer to work with @NadiaNasreddin in @owen_sansom's lab on the project WNT-driven cell competition: a target for novel preventative strategies against colorectal adenoma formation 📅Closing date: 15 August 2025 🔗 https://t.co/tED9IHS8SP