Akayama, Shima, Nakamura et al. (Nara Medical University) show that TFEB is regulated by at least two different regulatory mechanisms during lysosomal damage: ATG conjugation system–dependent/independent regulation. #Lysosomes #Autophagy

The multinucleate, multibudding yeast, A. pullulans delivers nuclei into each daughter bud during #mitosis. Petrucco, Gladfelter, Lew et al image #microtubules during mitosis, revealing mechanisms ensuring that most daughters inherit one & only one nucleus

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RT @maximewc: Great collaborating with the Russell lab on this paper. Tireless efforts from first author, Truc (Cloe) Losier, particularly….

Deng, Thorn et al. @Sydney_Uni report that liprin-α1 is part of a glucose-regulated complex controlling the positioning of #insulin granule fusion, revealing a novel step in the mechanism of stimulus–secretion coupling. #CellSignaling #Physiology

Truc Losier, Ryan Russell et al. @uOttawa identify distinct kinase signaling pathways that differentially regulate bulk and selective #autophagy. Using kinome-wide #CRISPR screening, they reveal both shared and pathway-specific regulators

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Spotlight: Woo Young Chung and Shmuel Muallem @NIDCR_NIH discuss recent work from Militsin et al. ( revealing how STIM1 and STIM2 affect #BreastCancer cell migration by regulating IP₃R-mediated Ca²⁺ release.

RT @Schliekerlab: Happy to see this excellent @laemmerdingLab discussion on our @schliekerlab and Mike's @hennelab recent work connecting o….

RT @HenneLab: Thankful for this writeup in @JCellBiol highlighting work from our group and the @Schliekerlab examining molecular factors th….

.@JulieHeffler and @LammerdingLab @CornellBME discuss recent studies from the @Schliekerlab ( and @hennelab ( that identify two proteins serving as crucial mechanical elements in the endoplasmic reticulum.

Make America Fentanyl Free supports President Trump’s efforts to end the fentanyl crisis.

New review: Mellor, Larson, and @DrMengWang discuss the molecular mechanisms of mammalian genomic instability arising from folate deficiency and how this impacts genome biology in health and disease. #CellMetabolism

Thompson, Stevenson et al @BristolUni show that two cis-Golgi golgins, GMAP210 & Golgin-160, have distinct roles in maintaining #Golgi organization & that both are required to support the efficient secretion, assembly, and modification of ECM proteins

The Tu lab show that a polymorphism in the Mkt1 gene underlies complex genetic phenotypes among strains of budding yeast. Mkt1 interacts w/ a #StressGranule protein Pbp1 to regulate expression of mitochondrial proteins, TORC1 signaling & autophagy in yeast

Narozna et al. uncover a high-frequency, chromosome 12-specific mis-segregation error in iPSCs. Eroded 12p arms lead to bridging & micronucleation, enabling widespread trisomy 12. A slight growth advantage allows trisomic cells to persist & dominate

@cosmicfibretion sorry to hear :/ it is a unique period to have free time. pro models are now excellent (rigorous) rubber ducks for all science musings.for show and tell, enjoying surface area and volume. with a suggestion of how it might be exhibited in quantum, and tested.

With a combination of FIB-SEM, super-resolution & expansion #microscopy, Araujo Alves, Bastin et al. reveal how IFT trains are progressively restricted to a limited number of #microtubule doublets in the flagellum of T. brucei.

RT @shoemaker_lab: The secret life of LIRs: Binding to Atg8-family proteins is just a fraction of what LIRs can do. .

Geng, Verhey et al find that KIF1C forms condensates where the exposed #kinesin motor domains entangle nearby #microtubules, causing them to bend & break in a process dependent on motor processivity, cluster properties, cytoplasmic viscosity, & MT anchors

Hawkins, Fernandez-Gonzalez et al. @UofT introduce ReSCU-Nets, recurrent neural networks for integrated segmentation and tracking of three-dimensional #microscopy images.

Spotlight: Needhi Bhalla highlights work from Narula and Wignall ( that describes an unexpected, noncanonical role for PLK-1 in the suppression of #centrosome maturation during #meiosis. #Celegans #Genetics.

Minami Hasegawa-Ogawa, Hirotaka James Okano et al. identify a dominant-negative TDP-43 isoform regulated by #ALS-linked #RNA-binding proteins. hnRNP K promotes its expression, while hnRNP A1 and FUS suppress it. #Disease #Neuroscience #RNAbiology

The man, the myth, the legend— at least, that’s what Kinta wants to be… . Catch the final arc of DAN DA DAN Season 2, now streaming!.

Zheng et al. @SUSTechSZ reveal that during starvation, SOD1, linked to #ALS, is transported into #lysosomes through #autophagy and the receptor protein TP53INP1. Within lysosomes, SOD1 regulates ROS levels and safeguards lysosomal activity and integrity.