Cancer Grand Challenges
@CancerGrand
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Daring to solve some of the most complex challenges in cancer research | Founded by: @CR_UK & @theNCI
London, UK | Bethesda, MD, USA
Joined May 2020
📜New in @ScienceMagazine: not one but two papers from team MATCHMAKERS!. The labs of David Baker @UWproteindesign and Chris Garcia @StanfordEMED published work that could revolutionise immunotherapy. The Baker lab unveil a generative AI pipeline to design precise binders for
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👏 Fantastic to see collaboration working to make radical progress #CancerGrandChallenges. @MDC_Berlin and @ChariteBerlin researchers Jan Dörr and Anton Henssen (member of team eDyNAmiC) found that targeting active and dormant #neuroblastoma cells improves treatment by.
#Neuroblastoma, a cancer mainly affecting children, is often difficult to treat. Researchers at #CharitéBerlin and the Max Delbrück Center now report a potential reason treatment sometimes fails and a new strategy to combat particularly resistant tumors. 👉
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Team MATCHMAKERS are co-funded with @TheMarkFdn through Cancer Grand Challenges — and this work highlights the impact of international organisations coming together. "This groundbreaking work exemplifies the power of global collaboration across disciplines and institutions. We.
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Great to see this important work also spotlighted in @FT. 📖 Read the full article -
ft.com
Research offers clues to choosing chemotherapy treatments with fewer long-term side effects
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Read more about team Mutographs paper in this @NatureGenet news and views piece, which also highlights the work of @DrKTakahashi and colleagues. 🔗
nature.com
Nature Genetics - Two complementary studies used whole-genome sequencing of single cell-derived hematopoietic colonies to show that chemotherapy results in a marked decrease in hematopoietic stem...
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"We hope such genomic data will guide the optimisation of future treatment plans to deliver effective chemotherapies with much fewer damaging side effects for patients.”. – Dr Jyoti Nangalia, @sangerinstitute
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"We are constantly on the lookout for better ways of giving therapy and minimising the side effects of toxic, systemic treatments. I’m hopeful that the genomic information from this and future studies will guide choices of chemotherapies, and their adoption in clinical practice.”
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Important new research from one of our Cancer Grand Challenge’s teams could help to improve cancer treatment choices in the future. While many cancers can now be targeted using precision therapies, chemotherapy remains a key way to treat some cancers and saves many lives every
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RT @anbu_ldr: Cracking Day 1 keynote talk by Prof Balmain at #PrevConf25: Cancer prevention isn’t just about avoiding mutations. Non-mutage….
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The PRECISION team have developed a deep‑learning model to accurately predict invasive recurrence of DCIS in patients that have been treated with breast-conserving surgery. Published in @eBioMedicine the model has the potential to reduce overtreatment. 🔗
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We are hiring! 🚨.Great opportunity to be at the forefront of cancer research on a global scale as a Research Portfolio Manager (based in our London office 2 days a week). Closing date: 1 July 2025.Get in touch with the team to learn more📩.More info 👇.
linkedin.com
Today's top 1,000+ Fixed Income Portfolio Manager jobs in United States. Leverage your professional network, and get hired. New Fixed Income Portfolio Manager jobs added daily.
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Challenge: Develop methods to identify the functional role of the tumour microenvironment over time. Awards of up to £20M available for global interdisciplinary teams. EOI deadline: 18 June. Apply:
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A massive thank you to everyone at #CGCecDNA, especially our co-organisers @mischellab, Mariam Jamal-Hanjani and @HowardYChang, and all of our fantastic speakers!. Together we’ll tackle the challenge of extrachromosomal DNA.
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That’s a wrap on #CGCecDNA!.Congratulations to our poster prize winners @ShirMarom, Yifat Bar Or Snarski and Alexandra Chelu!
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Zhijian (James) Chen, recently elected as a foreign member of the @royalsociety, brought the scientific programme of #CGCecDNA to a close by discussing ecDNA sensing pathways and harnessing them to target ecDNA positive cancers.
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Our panellists discussed the bottlenecks, fears, hopes and what surprises ecDNA biology may still have in store on the road towards developing transformative medicines.
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Mariam Jamal-Hanjani and @anton_gh led the second #CGCecDNA panel discussion:.‘From science to medicine’ with @HowardYChang from @Amgen, @ZacharyHornby from @BoundlessBio, Tonia Hafner from @genentech and Owen Wallace from Econic Biosciences.
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RT @CancerGrand: @samuels_yardena took us through revisiting the neoantigen approach to cancer immunotherapy with an ecDNA lens #CGCecDNA h….
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We kicked off the final day of #CGCecDNA with Ben Cravatt (@scrippsresearch) and innovative chemical approaches to target ecDNA in cancer.
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