What is the cardiovascular significance of adipose tissue surrounding the heart? Our study, published in @JAMACardio today, asked this question: https://t.co/Zkn1tmUkVP.

It’s my most privilege to work with such great mentors @shaan_khurshid, @aklfahed, @patrick_ellinor and brilliant minds @ShinoKany @tigerstatdoc @joeltramo, and many more! Looking forward to the expansion of clinical use cases for proteomic data😀

Now on medRxiv, we explore the genetic similarity between dilated cardiomyopathy (DCM) and peripartum, alcohol-induced, and cancer therapy-related cardiomyopathies (PPCM, ALCM, CCM). Led by star trio @DimitriMaamari, @kiranbiddinger, and @JurgensSean. https://t.co/HP798ztfU8

Is the ECG secretly a sphygmomanometer? We trained a neural net to predict hypertension from ECGs and found it associated with many cardiovascular outcomes.

Delighted to share our study led by @Harvard undergrad @akshayaravi22 with @broadinstitute postdoc @skoyamamd describing a general inverse genetic relationship between LDL-C and incident T2D. https://t.co/OQyhFkPAJz @JAMACardio

Just how many diseases can you identify with a good old 12-lead #ECG? NEW @npjDigitalMed, co-led w/ @lucidtronix, @RVpacing & @xwang, we use an autoencoder to map ECG to phenome, finding associations btwn ECG & >600 conditions @broadinstitute @broad_ml4h @MGHHeartHealth LINK⬇️

Is slow heart rate or conduction block heritable? Check out our new meta-analysis @NatureGenet incl common (~1.3m individuals) + rare (~400k) variants for bradyarrhythmias and conduction dz. Co-led w/ @LuChenWeng @joeltramo @JurgensSean @broadinstitute ! https://t.co/602MjN6iYk

#ICYMI: Rare Genetic Variants, LDL-C and Aortic Stenosis @jpirruccello @joeltramo @broadinstitute @MGHHeartHealth @UCSFCardiology @patrick_ellinor @shaan_khurshid @joeltramo @JurgensSean @ShinoKany @mahnazmaddah

We went on to perform Mendelian randomization, to find causal risk factors for DCM through genetics 🧬 We identified several potential causes of DCM, including AF, bodyweight, height and SBP with bodyweight and SBP remaining as independent and robust causal risk factors ♥️➡️❤️‍🔥

What is the role of common genetic variation in dilated cardiomyopathy (DCM) 🧬 and what causal pathways underlie the disease? 🫀 Happy to share our GWAS for DCM, published last week in @NatureGenet https://t.co/gez8IZwvZW @amsterdamumc @broadinstitute A detailed 🧵below:

In @NatureGenetics, our international team delivers a GWAS of dilated cardiomyopathy (DCM) - major cause of heart failure/transplant - led by @JurgensSean, @joeltramo, et al., with key leadership from @patrick_ellinor, @dalygene, @cbezzina1, and others. https://t.co/sxynn5UUhn

Incredibly excited that my friend & colleague @patrick_ellinor is the new Executive Director of the @MassGenBrigham Heart & Vascular Institute!! @MassGeneralNews @BrighamWomens

Deep dive on #EARLYTAVR from ##TCT2024 Lots already said & discussed It takes time to read the paper, read the supplementary appendix, analyse the results, think about them etc! Some thoughts...🧵

Exercise is beneficial for health. But many people have to cram their activity into 1-2 days/week. Do they still get the benefit? To find out, we looked at associations of "weekend warrior” (WW) physical activity) and >600 diseases, now @CircAHA ! A 🧵 https://t.co/lUQM0kjPHl

We are pleased to share our latest study entitled "Exome wide association study for blood lipids in 1,158,017 individuals from diverse populations" (1/19)

Excited to share our preprint led by @skoyamamd on the exome-wide analysis of blood lipids in 1.2M diverse individuals! In addition to id'ing new genes, we refine estimates of expressivity & penetrance of individual monogenic variants for lipids & CAD https://t.co/BqHyyFoS6Q

Simple question: Does ⬆️ LDL-C cause aortic stenosis (#AS)? NEW cutting edge work @CircAHA intersecting #WhyCMR / #AI & rare variant #genomics says YES Congrats @joeltramo @JurgensSean @ShinoKany @patrick_ellinor @jpirruccello ! @broadinstitute @MGHHeartHealth @UCSFHospitals

@JurgensSean This was a group effort with coauthors including Seung Hoan Choi, @xxinwang, Andrey Smirnov, @lucidtronix, @MahnazMaddah, and @shaan_khurshid. Huge thanks for making this study possible and better!

Also see the thread by @JurgensSean for a visual walk-through:

Is LDL-C a causal risk factor for aortic stenosis? We're excited to see our study now in @CircAHA examining this question by leveraging rare protein-disrupting variants in @uk_biobank and @AllofUsResearch. With @JurgensSean, @ShinoKany, @patrick_ellinor & @jpirruccello.

#SimPub #CircESC2024 Lifelong LDL-C levels, driven by rare genetic variants, significantly influence aortic stenosis (AS) risk. Findings suggest that early & sustained lipid-lowering therapy could be key in preventing AS. https://t.co/g2TtWgkaTK