Structural variants are an untapped source of neoantigens but their messy representation holds us back. Enter Occam's Variant Grammar: a unified variant representation for long-read guided neoantigen discovery in personalized immunotherapy development.

Have you ever wondered how a somatic inversion is detected? In this Tenet-inspired blog post, I break down the telltale signs: head-to-head (5' to 5') and tail-to-tail (3' to 3') inversion breakpoints.

RT @BenjaminGVincen: Update to our software for predicting tumor antigens using genomics data (LENS v1.7), done by @spvensko - Now with nat….

RT @iskander: After next round of the bake-off, going to pivot to tumor antigens (once we get some mass spec validation of which ones are r….

RT @DhuviKarthikey1: Took a year but today marks a very special day for @iam_js_lee and I. ACE may be used as a *teenie* part of a clinical….

RT @KlebanoffLab: 🚨Today in @CellCellPress, we show that RNA splicing factor mutations in myeloid cancers generate splicing-derived public….

RT @ac_palmer: New paper by @AmyEPomeroy!. A model of intratumor and interpatient heterogeneity explains clinical trials of curative combin….

RT @jasonlukemd: Extremely excited re: IMA203 - PRAME TCR T cells Ph 1 study published in @NatureMedicine! This is a transformative Rx in #….

RT @LukasValihrach: Scalable co-sequencing of RNA and DNA from individual nuclei

RT @rafalab: This UMAP plot was generated from data simulated without inherent clusters, meaning the observed clusters are artifacts. It….

RT @alexrives: We're thrilled to present ESM3 in @ScienceMagazine. ESM3 is a generative language model that reasons over the three fundamen….

RT @biorxiv_bioinfo: QUICHE reveals structural definitions of anti-tumor responses in triple negative breast cancer .

RT @VanAllenLab: Here's our latest, led by Drs. Riaz Gillani & @RyanLCollins13 - we studied a type of inherited genetic event (structural v….

RT @genomeresearch: SPECIAL ISSUE! This month @genomeresearch publishes a diverse collection of research and review articles in a special i….

RT @CatharineAquino: Some high level slides so you can imagine how @illumina constellation technology works presented by @nadia_sedl . I s….

RT @iskander: New de-novo TCR design preprint from @DhuviKarthikey1 just dropped:. TCR-TRANSLATE: Conditional Generation of Real Antigen Sp….

RT @PacBio: We’re excited to announce new long-read #sequencing chemistry for #Revio that will increase the system’s output & enable custom….

RT @iamharisankar: As we look to optimize more of Minimap2 on the GPUs in mm2-gb, we are looking for feedbacks from our user community. Ple….

RT @PeterLyLab: 🚨 Excited to share our latest paper in @CellCellPress identifying how under-replicated chromosomes in micronuclei become sh….

RT @ctsa11: Happy to introduce sawfish, a new HiFi structural variant caller emphasizing local haplotype modeling to improve SV representat….