Let’s dream a bit. How would you dramatically reorg biotech research / drug development to make dramatically faster progress towards curative therapies?. (Don’t say “use AI”, hypothesis/candidate generation under current structure isn’t a bottleneck).

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Alcohol use reduces the efficacy of anti-PD1 immunotherapy by disrupting anti-tumor immunity. Paper starts from an interesting observation

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I know way too little about how exactly a protein gets localized. Currently reading: . SRPassing Co-translational Targeting: The Role of the Signal Recognition Particle in Protein Targeting and mRNA Protection

RT @CorinWagen: New preprint! Bond-dissociation energies tell us how strong bonds are; these values are useful but historically slow to com….

TIL: Cellares. (.

RT @SimonDBarnett: Agree, this is the new status quo. Adapt or die. There’s some extremely brilliant science happening in China, combined w….

Funny consequence of using Deep Research is that sometimes the cited references seem interesting and important but aren't in English (so no way would I have found them myself): .

RT @SynBio1: My whole career, I've been baffled by how inefficient, slow and weird US biopharma seems. But the US was the source of most in….

RT @JoramMooiweer: @AdrianoAguzzi @OdedRechavi Agree, and apparently yes!.“Over 1,000 microPublication Biology articles are now discoverabl….

RT @thisischristina: Science is in crisis. When we’ve faced challenges in the past, scientists have retreated to the status quo. It’s time….

RT @owl_posting: A primer on ML in cryo-electron microscopy (cryo-EM). confused about cryo-EM???. i explain why pe….

Vero Beach is surprisingly good. (Population like 15k but great art museum, direct flights from a dozen places, cozy Old Florida architecture).

This is so cool! Ancient proteomics can reach further back in time than ancient DNA sequencing. AFAIK dinosaur fossil proteomics has been limited to a few collagen peptides shared with modern birds but this ancient rhino study sheds meaningful light on big stretches of proteins.

RT @iosif_lazaridis:

RT @InVitroFuture: @MdBatra @iskander All of this is consistent with what FDA and industry reps were saying at #MPS2025. Anything can chang….

I feel surprisingly sad unsubscribing from Claude, like I'm betraying an acquaintance or something. But. I use o3 for everything professional, and Claude only seems better at eg recipes.

Did anyone anticipate the NIH & FDA turning against animal research?. (I think it’s ethically great, scientifically shaky, and very surprising).

RT @elongilad: 🧵 THREAD: The Hebrew word for "one"—ekhad—seems ancient and unshakable. But here's the twist: it's a linguistic imposter tha….

o3 beats Claude at wetlab immunology questions every time. .