Bachochin et al. reveal the structural underpinnings of human Tom70, a key mitochondrial protein import receptor, and its internal flexibility which support chaperone coordination and substrate...

Bali et al. found that substitutions near tau’s conserved PGGG β-turn modulate its structure to suppress aggregation while preserving function. Guided by computational, NMR, and XL-MS analyses, the...

As 2025 comes to an end, we want to highlight some of the rising young faculty members who have published their exciting work from different areas of structural biology in Structure this year. We...

In this issue of Structure, Henriques et al. present structural snapshots that capture distinct conformational states of the type I-F Cas1-Cas2/3 integrase complex, illustrating that foreign DNA...

Deep-learning models have transformed structural biology by enabling reliable prediction of protein 3D structure models and providing confidence metrics such as predicted local distance difference...

(Structure 18, 1450–1462; November 10, 2010)

Fernández-Ramírez et al. report that amyloid fibrils formed by transthyretin carrying the T60A mutation, associated with patients with both cardiac and neuropathic manifestations, share a conserved...

Bacteria defend themselves against viruses by storing pieces of viral DNA in their genomes. Henriques et al. use cryogenic electron microscopy to determine how the Cas1-2/3 integrase captures,...

McMahon et al. present cryo-EM structures of DCAF2 and unveil DCAF2 as a novel E3 ligase for targeted protein degradation. By targeting C141 with bifunctional molecules, DCAF2 drives robust BRD4...

Hasan et al. discovered a new fatty acid binding site in fungal fatty acid synthases that is conserved across multiple pathogenic species of fungus. This small molecule-binding site inhibits fatty...

Mutations in proteasome subunits can cause proteasome-associated autoinflammatory syndromes (PRAASs), but the structural changes induced by these mutations have been largely elusive. By reporting...

Chenyao Li et al. using single particle cryogenic electron microscopy show that in detergent-solubilized ion channel RyR1, the channel switching between open and closed states can be modulated by...

Guo et al. generated a caninized mAb targeting canine IL-31 (cIL-31). The authors demonstrate its potent in vitro and in vivo efficacy and present the crystal structure of cIL-31 bound to its Fab....

Vander Meersche et al. present a large-scale analysis of the AlphaFold2/AlphaFold3/ESMFold confidence index pLDDT and flexibility metrics derived from molecular dynamics (MD) simulations. While...

Webb et al. aim to establish a structure-function relationship in cancer variants of the human capicua protein in this study. They report the crystal structure of a capicua construct containing both...

Han et al. integrate structurally resolved protein-protein interactions with genetic interactions to investigate the relationship between the divergence of protein-protein interaction structure and...

Asthana et al. identify new binding sites on VatD, an enzyme that inactivates streptogramin antibiotics. Their work reveals initial small molecules that inhibit VatD, laying groundwork for drugs to...

Wang et al. present an optimized labeling strategy for cryo-electron tomography based on genetically encoded FerriTag. This system uses rapamycin to recruit iron-loaded ferritin to target proteins,...