We just dropped our preprint: Introducing ECMSim This could be a game-changer for understanding heart tissue remodeling and testing therapeutic strategies in silico. 📄 Read the preprint: https://t.co/AfiCqZUBSm #CardiacModeling #ComputationalBiology #SystemsBiology #Heart

🧬 Aging Doesn’t Happen Gradually — It Crashes in Waves Find More Research: https://t.co/4OjFxljCVg A new Nature multi-omics study just shattered the “slow decline” myth of aging. Only 6.6% of molecular markers change linearly over time — the rest shift in sudden, nonlinear

MIT Entrance Exam 1869-1870.

In this thread, we'll explore the fascinating process of the SARS-CoV-2 spike protein opening motion using molecular modeling. 🧬 The journey from closed to open state is crucial for understanding this virus.

Demis Hassabis and John Jumper, the 2024 Nobel Prize laureates in chemistry, have developed an AI model to solve a 50-year-old problem: predicting proteins’ complex structures. In 2020, Hassabis and Jumper presented an AI model called AlphaFold2. With its help, they have been

AI in Protein Design: Hype vs. Reality Explained by David Baker In this GEN interview, he emphasizes that designing new proteins from scratch is now a reality. Whether AI transforms medicine will require improving our understanding of biology's complexity https://t.co/hmtqd2Iqxf

“My brain is only a receiver, in the Universe there is a core from which we obtain knowledge, strength and inspiration. I have not penetrated into the secrets of this core, but I know that it exists” ~ Nikola Tesla

Kurt Gödel, who was one of Albert Einstein's best friends in his later years, found a solution to general theory of relativity that modelled a strange, unusual and rotating universe allowing for backward time travel.

🧠 65-Hour Live Imaging: Hippocampal Neurons Building Circuits Real-time dendritic growth & synaptic remodeling in the rat hippocampus; important to memory & plasticity. 🔬 Continuous multi-day view of neural adaptation. Credit: Louis Romet & Dr. C. Leterrier

Join us this Tuesday at 2pm for our next AI+Biomedicine seminar, featuring @HannesStaerk on “BoltzGen: Toward Universal Binder Design” 📍2pm | Gates 415 | Stanford & Zoom

Microscopic “flowers” made from crystals and DNA open and close as the pH of the surrounding solution changes. Learn more in #ScienceAdviser: https://t.co/OikkKpB8FB 📥 Sign up for the daily #newsletter: https://t.co/mcqNeQWWFg

BoltzGen: Toward Universal Binder Design 1. BoltzGen is introduced as a novel all-atom generative model for universal binder design, uniquely capable of creating proteins and peptides of all modalities, including nanobodies, cyclic peptides, and globular proteins, to target a

A mind map illustrating the human immune system. https://t.co/vXEgEJ06Pq

OpenFold3 is finally out! New fully open-source AF3 reproduction from @open_fold Consortium Try it out on @tamarindbio now! The model is released with training code, similar performance to AlphaFold3 on protein-ligand complexes, best performance ever for RNA structure

New breakthrough quantum algorithm published in @Nature today: Our Willow chip has achieved the first-ever verifiable quantum advantage. Willow ran the algorithm - which we’ve named Quantum Echoes - 13,000x faster than the best classical algorithm on one of the world's fastest

Either Candi rush or Gold rush, AI boom is insane.

Depression hates a moving target. Keep your body & mind active. Depression thrives in stagnation & rumination.

Today we’re releasing real-world experimental data for over 1000 novel AI-designed proteins on our new platform @proteinbase!

Viral AlphaFold Database dropped! NCBI RefSeq → 647,000 viral protein seqs MMseqs2 → ~117,000 clusters AlphaFold2 → 26,962 monomers AlphaFold-Multimer → 26,754 homodimers Foldseek → 12,894 structural clusters Enjoy.

Cryo-EM structures reveal the molecular mechanism of SUMO E1–E2 thioester transfer | Nature Structural & Molecular Biology