William A. Wallace, Ph.D.
@drwilliamwallac
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*PhD spending days on the science inside the bottles on your shelf *Host of Daily Value podcast
Roanoke, VA
Joined October 2014
Choline reaches the brain largely as lysophosphatidylcholine (LPC, as it's called), which carries an omega-3 fatty acid. Increasing EPA+DHA increases this LPC flux, which raises delivery of both omega-3s and choline to cortical regions involved in learning and stress adaptation.
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Recovery from anxiety requires new learning in cortical circuits. Choline availability influences that process directly Animal + human work agree: • choline scarcity → impaired learning, memory formation, and circuit adaptation • choline sufficiency → enhanced plasticity
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New data shows that individuals with anxiety disorders reliably have ~8% lower choline-containing compounds in the cortex. This reduction reflects pressure on three choline-dependent processes: -phospholipid cycling in neuronal and myelin membranes -brain uptake and efflux of
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🔥 Your entire immune system starts with one cell. Every red blood cell that carries oxygen Every platelet that stops a cut from bleeding Every neutrophil that attacks bacteria Every T cell that hunts viruses Every B cell that makes antibodies All of them come from the same
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Your spine isn’t just a backbone, it’s your body’s "wiring harness." Your spine isn’t just a stack of bones. It’s the main cable connecting your brain to every organ, muscle, and sensation in your body. Each level of your spine sends out branches (spinal nerves) that control
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Every vitamin has a job. Every deficiency has a consequence. Every food choice moves the needle. A quick breakdown: 🔵 Vitamin D Bone strength and calcium absorption. Low levels raise the risk of weak bones and fatigue. 🟣 Vitamin B12 Builds DNA and protects nerves. Low B12
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Stress can reduce cognition (memory, attention) by ~20% (with respect to test scores) Certain botanicals (e.g., Rhodiola, Ashwagandha) may mitigate via HPA-axis regulation and neuroprotection Evidence is promising but requires standardization. As always, act with diet, sleep,
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LIPOIC ACID HAS BEEN CALLED THE ANTIOXIDANT OF ANTIOXIDANTS (This is largely due to its ability to recycle numerous antioxidant compounds in the body)
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Magnesium plays an important role in blood pressure regulation, as demonstrated by its influence on endothelial function, calcium efflux, and oxidative stress. Magnesium deficiency can contribute to endothelial dysfunction, increased oxidative stress, and vascular remodeling, all
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This is the first meta-analysis to show a chemical pattern in the brain in anxiety disorders (i.e., across different kinds of anxiety disorders). Choline is an essential nutrient that neurons use to build membranes and regulate signaling, especially in regions involved in
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Essential nutrients run the entire operating system of your body. The importance of minerals cannot be understated Every heartbeat, every muscle contraction, every memory, every immune response, minerals are behind it. Here’s what you’re looking at: 🟡 Calcium: not just for
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Your mitochondria are not batteries, they’re chemical factories. And this is what they’re building.... This diagram looks complex because it is. Your mitochondria act like tiny biochemical control centers that influence how well you think, heal, detoxify, fight infection, and
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Your gut: a 7-meter assembly line extracting every usable molecule with molecular specificity. This figure maps how different sections of the gastrointestinal tract specialize in absorbing specific nutrients. From the stomach to the large intestine, each region has a defined
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Taurine is a sulfur-containing amino acid known for its critical involvement in skeletal muscle, heart and brain function. With high concentrations found in excitable tissues such as muscle, brain, and heart, taurine is essential for maintaining cellular homeostasis. It
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When gut imbalance turns into whole-body inflammation This figure shows how an unhealthy gut microbiome can set off a chain reaction that affects metabolism, hormones, and nearly every major organ system. When the gut barrier weakens, bacterial toxins leak into the bloodstream,
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Is your multivitamin actually doing anything? This review pulled together data from dozens of studies looking at how daily multivitamin/mineral use shows up across real biological systems; not just “general health,” but cognition, immunity, pregnancy outcomes, eye health, and
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Your heart starts with a single cell that learns to beat. What you’re seeing This video shows a stem cell transforming into a heart muscle cell, or cardiomyocyte. As it develops, the cell organizes its internal scaffolding, forms contractile fibers called sarcomeres, and begins
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MAGNESIUM FORM LIKELY DOESNT MATTER WHEN USED CONSISTENTLY. Most long-term research shows no meaningful cognitive advantage for any specific magnesium salt. In a 2024 meta-analysis, higher total magnesium intake improved global cognition and working memory regardless of form,
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Researchers gave arginine to mice and fruit flies engineered to develop Alzheimer’s-like pathology. The result? Far less amyloid buildup, fewer brain plaques, lower inflammation, and better behavior, even though the disease genes were still there. Before you jump: this is NOT a
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