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William A. Wallace, Ph.D. Profile
William A. Wallace, Ph.D.

@drwilliamwallac

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• Scientist | Director, Product Development & Scientific Affairs • R&D | Innovation Strategy | Formulation | Regulatory • Health Educator

Roanoke, VA
Joined October 2014
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@drwilliamwallac
William A. Wallace, Ph.D.
11 hours
L-Theanine (N-ethyl-L-glutamine), an amino acid prominently found in Camellia sinensis (green tea), influences cognitive and emotional states primarily through modulation of cortical brain wave activity. The compound preferentially increases alpha-wave generation, indicative of
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@drwilliamwallac
William A. Wallace, Ph.D.
15 hours
The gut-brain axis is a bidirectional communication network between the gastrointestinal tract and the central nervous system. This dynamic system integrates neural, endocrine, immune, and metabolic signals, many of which are modulated by the gut microbiota. 🧠 1. Neural Pathway
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@grok
Grok
6 days
What do you want to know?.
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@drwilliamwallac
William A. Wallace, Ph.D.
17 hours
🧠Women normally have more omega-3s in their brains than men - a built-in advantage. But in Alzheimer’s, that protection collapses. A new study of 841 people shows:. ✳️Women with AD had a sharp drop in omega-3–rich fats, men did not. ✳️The drop tracked with worse memory & more
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@drwilliamwallac
William A. Wallace, Ph.D.
20 hours
This is the first study to show that blood lipids could help explain why women carry greater risk for Alzheimer’s disease. 🧠. A 2025 study in Alzheimer’s & Dementia (PMID: 40832908) analyzed 841 adults across Europe using high-resolution lipid profiling. Study Groups:. - Women
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@drwilliamwallac
William A. Wallace, Ph.D.
1 day
The muscle-brain connection: The role of exercise-induced myokines in combatting aging-delated disease(s). Last week, I made a post on myokines—signaling molecules secreted by muscles in response to exercise, and their impact on multiple different organ systems. This post is
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@drwilliamwallac
William A. Wallace, Ph.D.
2 days
A 22-month mouse study found that oral nicotine (not smoke) reprograms aging metabolism: preserving motor function, stabilizing gut microbes, and elevating NAD⁺ via sphingolipid turnover. Risks remain, but biology is more nuanced than the headline.
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@drwilliamwallac
William A. Wallace, Ph.D.
2 days
Hydration may do more than keep you alert. It could determine how your body handles stress. 💧🧠. Water has long been tied to clearer skin, appetite control, and energy. But researchers at Liverpool John Moores University have now shown that habitual fluid intake directly shapes
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@drwilliamwallac
William A. Wallace, Ph.D.
2 days
📊 A new review on protein quality highlights:. EAA density (%EAAs/kcal) is key - animal proteins deliver the highest quality vs plants. For groups with lower energy needs (e.g., older sedentary women, ~1600 kcal/d), a whole-food vegan diet may require ~300 extra kcal/day to
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@drwilliamwallac
William A. Wallace, Ph.D.
3 days
Acute exercise doesn’t just stress muscles; it reshapes the gut. 🧬🏃‍♂️. Even one workout transiently rewires gut microbial activity, hinting at a mechanistic link between exercise, microbiota, and host performance. A review in Experimental Physiology shows a single bout of
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@drwilliamwallac
William A. Wallace, Ph.D.
3 days
Vitamin K as a neuroprotective agent. A recent series of studies highlights the neuroprotective potential of vitamin K, particularly vitamin K2, revealing significant associations between its intake, brain concentration, and markers of cognitive health. The research found that:
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@drwilliamwallac
William A. Wallace, Ph.D.
3 days
Exercise stimulates a cascade of neurochemical and structural changes that reinforce the brain’s resilience, plasticity, and performance. Beyond the cognitive benefits, endorphins and enkephalins are released, modulating pain perception and fostering a sense of well-being.
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@drwilliamwallac
William A. Wallace, Ph.D.
4 days
11 Evidence-based Health Benefits of Blueberries:. 1) Nutrient-rich - 150g portion can supply 1/4 of vitamin C and manganese requirements, 1/3 of vitamin K1 needs, and also provide vitamin E and copper. 2) Support gut health - antioxidants and fiber in blueberries both support
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@drwilliamwallac
William A. Wallace, Ph.D.
4 days
Sunlight, supplements, and your genes all fight for control over vitamin D. 🧬☀️ A new review shows why some people stay deficient despite the same diet or UV exposure . It’s written in their DNA.
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@drwilliamwallac
William A. Wallace, Ph.D.
4 days
Epidermal thinning is a hallmark of skin aging, reducing barrier integrity and regenerative potential. This study suggests that vitamin C doesn't merely act as an antioxidant or cofactor for collagen synthesis, but it it may help “flip” epigenetic switches that restore a more
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@drwilliamwallac
William A. Wallace, Ph.D.
4 days
10 g/kg carbs after exhaustive cycling fully restores liver glycogen in 6 h, but muscle glycogen lags, only ~70% replenished after 12 h.
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@drwilliamwallac
William A. Wallace, Ph.D.
5 days
🗂️ Case File: The Aging Brain. Subject: Neuronal Energy Decline.Status: Ongoing . Findings:. Aging neurons lose ATP and NAD⁺, cutting off supply to GTP, a necessary l but overlooked fuel. Without GTP, vesicular trafficking and autophagy stall → toxic proteins accumulate. UC
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@drwilliamwallac
William A. Wallace, Ph.D.
5 days
Cognitive function [among other things] is influenced by the availability and metabolism of amino acids. This graphic is meant to highlight the multifaceted roles of specific amino acids in neural pathways. For instance, β-alanine stands as a neuromodulator with affinities for
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@drwilliamwallac
William A. Wallace, Ph.D.
5 days
Parkinson’s disease has long been defined by the death of neurons in the brain. Yet, decades before tremors appear, the first signs emerge quietly in the gut. Recent evidence reveals a puzzling disappearance: microbial pathways that once produced two well-known compounds fall
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@drwilliamwallac
William A. Wallace, Ph.D.
5 days
The brain requires a constant supply of vitamins and minerals for energy metabolism, antioxidant defense, neurotransmitter synthesis, ion homeostasis, metabolism, and to maintain basal cognitive function. Surprisingly, the science on the impact of nutrition and brain health is
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@drwilliamwallac
William A. Wallace, Ph.D.
6 days
Very hot beverages may carry a carcinogenic risk - not because of the drink itself, but because of the temperature. In 2016, the International Agency for Research on Cancer (IARC) classified drinking beverages above 65 °C as “probably carcinogenic to humans.”. This places very
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