Explore tweets tagged as #TRPML1
Published in @NatureComms, the 3.5 Å #cryoEM structure of human lysosomal channel TRPML1 with natural lipid PtdIns(3,5)P2 from Dr Xiaochun Li and colleagues in #UTSW (@UTSWNews). Just one of 43 fantastic maps released this week @EMDB_EMPIAR. Take a look!.
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Check out this #EditorsPick from #PapersoftheWeek by Xing et al. and @NatureComms showing fine control by lysosomes on macrophage inflammatory function via regulation of lysosomal cation channel TRPML1 #PRF
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High throughput cryo-EM provides structural understanding for modulators of the lysosomal ion channel TRPML1. 結晶構造解析のように、高いスループットで膜タンパク質のアゴニストとアンタゴニストを探索する. と言う、お話.
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The lysosomal carrier SLC29A3 supports anti-bacterial signaling and promotes autophagy by activating TRPML1 in mouse dendritic cells #biorxiv_cellbio.
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The ion channel #TRPML1 within #lysosomes initiates calcium sparks in vascular smooth muscle cells by forming complexes with type 2 ryanodine receptors, according to a study from @unrmed. #CalciumSignaling Credit: Thakore et al.
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Feng, Cai, Xu et al. @ZJU_China report that saturated fatty acids cause mitochondrial damage and ROS elevation in human endothelial cells. Activation of #lysosome biogenesis using TRPML1 agonists is sufficient to mitigate SFA-induced #mitochondria damage.
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A shoutout to Scott Earley's @vesselman group with their latest manuscript looking at Ca2+ release channel TRPML1. Excited to see contributions from their @3i_inc Lattice LightSheet in print (and in video)! (Movie S2 showing LysoTracker-labeled LEL mobility & particle tracking.)
The intracellular Ca2+ release channel TRPML1 regulates lower urinary tract smooth muscle contractility . The latest work from our team - an unusual role for TRPML1 channels!.
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New online! DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation
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リソソーム局在はシナプス可塑性制御に重要！(EMBO J). mTORC1の制御因子として知られているLAMTOR1がTRPML1の抑制を介して、樹状突起へのリソソームの局在化、並びに[Ca2+]↑に伴うAMPA受容体の内在化/分解を抑制することでシナプス可塑性を制御！. #2022年論文紹介38.
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Online now! High throughput cryo-EM provides structural understanding for modulators of the lysosomal ion channel TRPML1
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The Role of Lipids and Mutations in Controlling TRPML1 and Rare Disorders.
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Interesting new PLoS Biol paper on a potential mTOR-independent function of rapamycin in stimulating autophagy through a TRPML1/Calcineurin/TFEB pathway:
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𝐅𝐫𝐨𝐦 𝐍𝐘𝐒𝐄: San Diego based @LibraBiotech is aiming to boost protein clearance in neurodegenerative diseases by targeting TRPML1. Full video:
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THE LYSOSOMAL CALCIUM CHANNEL TRPML1 CONTROL DENDRITIC CELL MIGRATION AND ANTITUMOR IMMUNE RESPONSES. Ana-Maria Lennon-Duménil
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A single aspartate residue is critical for both fast and slow calcium-dependent inactivation of the human TRPML1 channel.
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Mitochondria-lysosome contacts regulate mitochondrial Ca2+ dynamics via lysosomal TRPML1
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4/x. Mechanistic support for the disarming model. Unopposed weak agonistic input leads to attrition of functional potential in cells that lack self-specific inhibitory receptors. We propose a role for TRPML1-mediated lysosomal remodelling downstream of activation receptors.
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Using state-of-the-art imaging and #superresolutionmicroscopy, the Earley lab discovers how the ion channel #TRPML1 initiates calcium sparks to control blood pressure and arterial contractility. @unrmed Credit: Thakore et al.
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Alzheimer’s Association International Conference kicks off today! Register at: Listen to DRNI member Prof. Cora O’Neill’s on-demand session on TRPML1. DRNI member Prof. Marina Lynch talks about immunity in the brain at 5.30pm (Irish time) #AAIC2020
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