Calì_Lab
@lab_cali
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Tito Calì lab @UniPadova, Full Professor @dsb_unipd. Organelle Contacts, Neurodegeneration. SPLICS and split-FPs based reporters. @[email protected]
Padova
Joined March 2020
Group photo!. 👇 👇 👇 👇 👇. Alberto Elena Lucia Flavia Jessica De. Covallero Poggio Barazzuol Giamogante Almeida R.
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RT @Structure_CP: Online now! Fungal kinesin-8 motors dimerize by folding their proximal tail domain into a compact helical bundle https://….
cell.com
Trofimova et al. reveal that fungal kinesin-8 motors dimerize via a compact four-helix tail bundle, rather than a canonical coiled coil. A flexible, non-dimerizing neck extension links this bundle to...
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RT @cell_club: Multiple interactions recruit BLTP2 to ER-PM contacts to control plasma membrane dynamics
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Proud to share the collaborative work with @NasuLab_IBC & @Campbell_FPs (Robert E. Campbell)! Split biosensors have been developed to intrinsically monitor membrane contact & Ca��⁺ exchange simultaneously—no chemical fluorophores required! 👉 .
pubs.acs.org
Self-complementing bipartite fluorescent proteins (FPs) are useful tools for the detection of protein–protein proximity and for localizing fluorophores to membrane–membrane contact sites. Here, we...
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RT @Linkermann_Lab: Thank you @GerryMelino for selecting our recent work for a highlight in #CellDeathDifferentiation. .
nature.com
Cell Death & Differentiation - Oestradiol-mediated ferroptosis defense shapes sex differences in acute kidney injury
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RT @NatureSMB: New online! Dynamic TOM–TIM23 supercomplex directs mitochondrial protein translocation and sorting h….
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RT @ShorterLab: Putative PINK1/Parkin activators lower the threshold for mitophagy by sensitizing cells to mitochondrial stress | Science A….
science.org
Drugs targeting mitochondrial removal show unexpected mechanisms with implications for Parkinson’s therapeutics.
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RT @NobelPrize: "I learned that any difficult problem can be solved by great effort.". Remembering Osamu Shimomura, born #OTD in 1928, who….
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RT @MolecularCell: Online Now: A regulator of amino acid sensing links lipid peroxidation and lipid droplet-dependent antioxidant response….
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RT @Eric_Betzig: 3D cross-sectional views of the dynamics of chromosomes (H2B, blue) and the endoplasmic reticulum (orange) in interphase a….
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RT @cell_club: The RAB27A effector SYTL5 regulates mitophagy and mitochondrial metabolism | bioRxiv
biorxiv.org
SYTL5 is a member of the Synaptotagmin-Like (SYTL) protein family that differs from the Synaptotagmin family by having a unique N-terminal Synaptotagmin homology domain that directly interacts with...
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RT @biorxiv_cellbio: Plasma membrane accessible cholesterol is regulated by ACC1 and lipid droplets #biorxiv_cellbio.
biorxiv.org
Proper maintenance of plasma membrane (PM) cholesterol is essential for diverse processes ranging from animal development to pathogen evasion. Despite decades of study, the mechanisms governing...
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RT @biorxiv_cellbio: LRRK2G2019S acts as a dominant interfering mutant in the context of iron overload #biorxiv_cel….
biorxiv.org
A key pathological feature of Parkinson’s Disease (PD) is the loss of neuromelanin, an iron chelator within the dopaminergic neurons, which results in iron toxicity thought to result in selective...
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RT @rust_ruslan: ApoE4 disrupts intracellular trafficking and iron homeostasis in a reproducible iPSC-based model of human brain endothelia….
cell.com
Bell and colleagues develop a new protocol to differentiate brain endothelial cells from iPSC to investigate the regulation of intracellular transport across the blood-brain barrier. They find that...
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Opportunities in proximity modulation: Bridging academia and industry: Molecular Cell
cell.com
Proximity-inducing modalities enable reprogramming of cells and offer exciting therapeutic potential. Here, we discuss how academic and industrial efforts, along with their collaborations, have...
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An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease: Cell Reports
cell.com
Harhai and collaborators expand the catalog of genes essential for oxidative phosphorylation and implicate FAM136A in mitochondrial proteostasis. Their findings suggest a mitochondrial contribution...
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RT @GGouspillou: Ankyrin-B modulates mitochondrial fission in skeletal muscle and is required for optimal endurance exercise capacity | Nat….
nature.com
Nature Communications - Scaffolding protein ankyrin-B, implicated in cardiometabolic syndrome, enables mitochondrial fission and flexibility of nutrient utilization under energetic stress in...
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RT @cell_club: CHIP protects lysosomes from CLN4 mutant-induced membrane damage.
nature.com
Nature Cell Biology - Lee et al. use an aggregation-prone CLN4 mutant that causes lysosomal damage in neurons and show that in non-neurons, the ubiquitin ligase CHIP prevents CLN4-dependent...
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