Scott Earley
@vesselman
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It is debated whether poor #blood flow underlies white matter loss in #aging. Our recent study in aged mice supports this idea: Impaired drainage through rare, deep-reaching #venules causes mild #hypoperfusion that triggers inflammation and demyelination. https://t.co/nDVjgZjnWa
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Great work from the @trebaklab et al! Congratulations!
Loss of the calcium sensor #STIM2, but not of STIM1, worsens #ColorectalCancer growth and metastasis by boosting calcium ion content in the endoplasmic reticulum, remodeling mitochondria, and rewiring transcriptional activity. @TrebakM @Trayambak_P
https://t.co/DF0DZu5Jza
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A fantastic review from Hugh Markus and Anne Joutel! The pathogenesis of cerebral small vessel disease and vascular cognitive impairment | Physiological Reviews | American Physiological Society
journals.physiology.org
Cerebral small vessel disease (cSVD) is the broadly accepted term nowadays to designate a heterogeneous group of diseases caused by in situ damage of small brain vessels commonly related to aging,...
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🎉 Excited to share our new paper in Science Signaling on #brain #pericytes constriction and TRPC3 channel—now published, featured on the cover, and highlighted in a Focus by @vesselman 🧠🧪 Check it out: https://t.co/3hMjSZ9v6C
@AMCPharmacology @CUAnschutz #Neurovascular #TRP
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#Microtubule #SmoothMuscleCell Contractility MT support #SarcoplasmicReticulum - #PlasmaMembrance contact RyR2 channel clusters on tubulin filaments Nocodazole (but not actin toxins latrunculin B or swinholide A) ⏫Ca2+ spark spread ⏬RyR2-BKα co-localization ⏬STOC
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Here's a free link to our commentary on the latest paper from @NelsonLab1 Shocking insights for neurovascular coupling: Electrical signals ignit...
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Just over 2 days left to apply for our PhD project! Please share and apply before Friday
Are you interested in discovering how blood flow to the brain is controlled and how it goes wrong in dementia? We have a MRC DTP project with @adamsgreenstein @stu_art_here & Ingo Schiessl, using state-of-the-art methods and models. Please share
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Well deserved! Congratulations!
Humbled and honored to be named the recipient of the 2025 Robert M. Berne Distinguished Lectureship @APSPhysiology CVS Section. Thanks to the many mentors, advisors, colleagues & friends. @ucdavis, @UCDavisHealth, @MCIPUCD, @PTXatUCD, @MNCline
https://t.co/VtbpS2CUKc
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Check out our new offering. Great collaboration with Serysheva lab. @Irina52948708
https://t.co/yEtMetTiKy
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Super exciting that this amazing work by our lab led by the brilliant @Jadeltaylor19 has been nominated! Please do vote if you’re able 🙌🏼
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We have a few more slots left. Please join us in sunny Tuscon! (its a dry heat…)
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I'm delighted to announce that the Earley Lab will be moving to @URMC Department of Pharmacology & Physiology as of August 1! We have multiple positions for postdocs, res. scientists, and Ph.D. students interested in vascular TRP channels, blood flow in the brain, and cSVDs.
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Don't forget to register by June 23 to take advantage of the early registration discount for #VASOSRC
https://t.co/7EzIIkCFFz
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Want to save $150 to hear the latest research at #VASOSRC before it hits the journals? Register by June 23 and save your space: https://t.co/XlF94CejvS
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Happy to share this work by @MNCline group of the #MnMLab on several new research areas for us. Check it out: Nicotine Impairs Smooth Muscle cAMP Signaling and Vascular Reactivity. @ucdavis, @UCDavisHealth, @UCDavisResearch
https://t.co/wPrDacIyMm
onlinelibrary.wiley.com
Objective This study aimed to determine nicotine's impact on receptor-mediated cyclic adenosine monophosphate (cAMP) synthesis in vascular smooth muscle (VSM). We hypothesize that nicotine impairs...
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The abstract deadline is June 9th! Submit today!
The abstract submission deadline is June 9. Submit your research today for #VASOSRC and save your space: https://t.co/a5xEG97vAD
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