This week’s new issue of #ScienceSignaling has arrived! CRISPR experiments uncover a factor that facilitates immune receptor diversity, scientists identify a self-limiting mechanism that keeps the important Wnt signaling pathway in check, and more. https://t.co/HPHgp9ZogS

New experiments in mice show how the enzyme SPEG prevents the leakage of calcium ions in skeletal muscle cells—a finding that could inform research into diseases associated with mutations in the calcium-releasing channel #RYR1. @BCMIntegrPhys https://t.co/3wYiMYIfQ0

New findings in mice cast light on the pathways behind the growth of painful bone tumors in hereditary multiple #osteochondroma and suggest that these mechanisms could be targeted to slow the disease’s progression. @ChildrensPhila https://t.co/GojcNz8QSw

New findings reveal a negative feedback mechanism centering on ZNRF3 and the FZD receptor that restricts Wnt signaling by specifically targeting activated receptors—but not all receptors—for degradation. @Novartis https://t.co/FxSzYjlEyf

Using CRISPR knockout screens, a team identifies the enzyme #senataxin as a key redundant factor in #VDJRecombination, showing that it is needed to repair DNA breaks induced by RAG1/2 in cells treated with an ATM inhibitor. @institutpasteur https://t.co/scFafVfn9l

New experiments in mice show how the enzyme SPEG prevents the leakage of calcium ions in skeletal muscle cells—a finding that could inform research into diseases associated with mutations in the calcium-releasing channel #RYR1. @BCMIntegrPhys https://t.co/3wYiMYIfQ0

New findings in mice cast light on the pathways behind the growth of painful bone tumors in hereditary multiple #osteochondroma and suggest that these mechanisms could be targeted to slow the disease’s progression. @ChildrensPhila https://t.co/GojcNz8QSw

Scientists have identified a degradation mechanism for a voltage-gated potassium channel that acts as an important brake on its activity in neuronal and immune cells, according to new in vitro experiments. @IBUB_UB https://t.co/UMhuoZP6dw

Researchers have mapped out the genetic and proteomic effects of a protein named MYC that is intimately linked to #cancer growth—a discovery that could lead to new therapies aimed at this “undruggable” target. @UNC_CBP @cjder23 https://t.co/bsRh0vKpR8

A team shows that the kinase SPEG inhibits calcium leak in skeletal muscle cells by phosphorylating the channel RYR1, suggesting that reducing calcium leak through mutant RYR1 could prevent associated pathologies. @BCMIntegrPhys #CalciumSignaling https://t.co/3wYiMYIfQ0

Osteochondromas in hereditary multiple #osteochondromas follow a growth axis orthogonal to growth plates that involves Hedgehog signaling within basal cartilage and the protein PTHrP on the outer edges, according to new work in mice. @ChildrensPhila https://t.co/GojcNz8QSw

Researchers delineate how a pathway drives the growth of bone tumors in a painful inherited bone disorder, new experiments in mice show how an enzyme inhibits the leakage of calcium ions in skeletal muscle cells, and more this week in #ScienceSignaling. https://t.co/irkK9GGStP

Scientists have identified a degradation mechanism for a voltage-gated potassium channel that acts as an important brake on its activity in neuronal and immune cells, according to new in vitro experiments. @IBUB_UB https://t.co/UMhuoZP6dw

Researchers have mapped out the genetic and proteomic effects of a protein named MYC that is intimately linked to #cancer growth—a discovery that could lead to new therapies aimed at this “undruggable” target. @UNC_CBP @cjder23 https://t.co/bsRh0vKpR8

New findings reveal how a co-receptor named TIM3 on T cells functions differently depending on its cellular context—a discovery that could aid in the development of drugs that target this co-receptor. @CMMBristol https://t.co/Dq7V57x2a6

Researchers have discovered a signaling mechanism that prevents T helper 17 cells from adopting pathogenic states linked to #autoimmunity, potentially informing future efforts to treat autoimmune diseases such as multiple sclerosis. @BRFAA_IIBEAA https://t.co/dUgcIhO3Zs

A degradation mechanism for the voltage-gated potassium channel #Kv1.3 based on the #ubiquitylation of lysine residue clusters facilitates its internalization and destruction and acts as an important check on Kv1.3 currents in T cells. @IBUB_UB https://t.co/UMhuoZP6dw

This week, a team constructs a wide-ranging molecular atlas of MYC in #PancreaticCancer cells, shows that MYC is needed for many of the oncogenic effects of mutant KRAS, and identifies several targetable MYC-interacting kinases. @cjder23 @UNC_CBP https://t.co/bsRh0vKpR8

The new issue of #ScienceSignaling is out now! A molecular portrait of MYC signaling could inform future therapies for pancreatic cancer, scientists identify a degradation mechanism that keeps a potassium channel in check, and more. https://t.co/xOYWfXHtjb

New findings reveal how a co-receptor named TIM3 on T cells functions differently depending on its cellular context—a discovery that could aid in the development of drugs that target this co-receptor. @CMMBristol https://t.co/Dq7V57x2a6