Science Signaling
@scisignal
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Uncovering mechanisms in biology, gaining insights into physiology and disease.
Washington, DC
Joined April 2010
This week’s new issue of #ScienceSignaling has arrived! A new study defines the regulation of a receptor that’s central to allergic inflammation, scientists map out the landscape of cancer-linked KRAS signaling, and more.
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Small extracellular vesicles released by tumors recruit nociceptor sensory neurons that contribute to an immunosuppressive tumor environment in mouse models of #HeadAndNeckCancer, according to new work. @SanfordResearch
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The new issue of #ScienceSignaling is out now! This week, scientists discover how tumor-derived vesicles reprogram pain-sensing neurons to dampen anti-tumor immunity in mice.
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New research maps out how drugs that inhibit hyperactive forms of the protein #KRAS affect its ability to drive cell proliferation in #cancer and may guide therapeutic strategies to overcome KRAS inhibitor resistance. @TU_Muenchen @kusterlab.
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The approved drug #asciminib may be more effective against leukemias driven by the fusion protein BCR-ABL than it is against those driven by TEL-ABL, show new in vitro findings that may have implications for the drug’s clinical use. @VUBasicSciences
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A proinflammatory protein named RIPK3 can also suppress inflammation in cells called #astrocytes during #Zika virus infection, adding nuance to how scientists understand the role of RIPK3 in viral infections of the nervous system.
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New experiments define the regulation of the Fc-epsilon-RI receptor—a central player in allergic responses and inflammation—and define a mechanism that sustains #allergy signaling and could be a promising therapeutic target. @ShenzhenUni .
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This week, scientists analyze the proteomes of KRAS-mutant cancer cell lines treated with various inhibitors and map out shared and cell-specific differences in KRAS signaling networks that shape drug responses. @TU_Muenchen @kusterlab.
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Mast cells central to type I #allergy depend on the enzyme USP5 to release allergic factors in response to IgE through a mechanism involving the deubiquitylation of the Fc-epsilon-RI receptor, according to a new study. @ShenzhenUni.
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Scientists have untangled how colorectal cancer cells can develop resistance to a new class of drugs called RAS(ON) inhibitors—a finding that could inform efforts to overcome drug resistance in #CRC and other types of tumors. @ChariteBerlin
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The approved drug #asciminib may be more effective against leukemias driven by the fusion protein BCR-ABL than it is against those driven by TEL-ABL, show new in vitro findings that may have implications for the drug’s clinical use. @VUBasicSciences
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A proinflammatory protein named RIPK3 can also suppress inflammation in cells called #astrocytes during #Zika virus infection, adding nuance to how scientists understand the role of RIPK3 in viral infections of the nervous system. @briandanielsli @RutgersU
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In this week’s Editors’ Choice piece, we highlight a study by Medkour and colleagues in @Cell_Metabolism, showing that sphingomyelins in mosquito saliva enhance flavivirus infection by preventing viral protein degradation. Read a summary:
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Researchers discover that a high-fat diet damages the heart in mice by disrupting metabolism in heart cells called #cardiomyocytes but find that knocking out the enzyme PTP1B can prevent these harmful effects. @MasonicResearch @mkontari
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Leveraging a reporter of the RAS pathway, a team finds that #ColorectalCancer cells can eventually develop resistance to “RAS(ON)” inhibitors and identify various non-oncogenic secondary mutations that contribute to this resistance. @ChariteBerlin
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Removing PTP1B—a phosphatase linked to #obesity—can shield the heart from #cardiomyopathy and steatosis in mice fed a high-fat diet by preventing cardiomyocytes from switching from fatty acid oxidation to glucose metabolism. @mkontari @MasonicResearch
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Flipping off an enzymatic switch protects the heart from a high-fat diet in mice, new experiments in cells untangle how colorectal cancer cells can develop resistance to RAS inhibitors, and more this week in #ScienceSignaling.
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The approved drug #asciminib may be more effective against leukemias driven by the fusion protein BCR-ABL than it is against those driven by TEL-ABL show new in vitro findings that may have implications for the drug’s clinical use. @VUBasicSciences
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A proinflammatory protein named RIPK3 can also suppress inflammation in cells called #astrocytes during #Zika virus infection, adding nuance to how scientists understand the role of RIPK3 in viral infections of the nervous system. @briandanielsli @RutgersU
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New #CryoEM discoveries are decoding the structural properties and evolution of the TSC2 protein complex, which acts as a key brake on the cell growth-promoting #mTORC1 signaling pathway. @lab_manning @HarvardChanSPH. Check out the Review:
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