bioRxiv Cell Biology
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Reserpine prolongs lifespan but compromises heat-stress resilience in Drosophila melanogaster #biorxiv_cellbio.
biorxiv.org
Pharmacological modulation of monoaminergic signaling, a process targeted by many therapeutic and recreational drugs via receptors, transporters, degradation enzymes, or reuptake mechanisms, is...
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Cholesterol metabolism modulation facilitates CAR-T induced killing of ovarian cancer #biorxiv_cellbio.
biorxiv.org
Ovarian cancer is one of the most lethal gynecological cancers worldwide and has one of the highest recurrence rates. Recently developed Chimeric Antigen Receptor T (CAR-T) cell therapy has shown...
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Spatiotemporal dynamics of signal dependent exocytosis and parasitophorous vacuolar membrane rupture during Plasmodium falciparum egress. #biorxiv_cellbio.
biorxiv.org
Malaria, caused by intracellular Plasmodium parasites, remains a major global health concern. These parasites reside and replicate within a vacuole in host red blood cells. Egress of daughter...
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Mapping the impact of microplastics exposure on enteric viral infections in intestinal organoid models #biorxiv_cellbio.
biorxiv.org
Micro- and nanoplastics (MNPs) are pervasive environmental pollutants increasingly detected in human tissues, yet their long-term health consequences remain poorly understood. The intestinal epithe...
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Proteomic Signatures of Podocyte Injury Are Reflected in Urinary Extracellular Vesicles in Pediatric Nephrotic Syndrome. #biorxiv_cellbio.
biorxiv.org
Idiopathic nephrotic syndrome (NS) is a common glomerulopathy in children and presents with significant proteinuria. There are no reliable clinical or biochemical markers of disease relapse, or...
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Anti-vitronectin single-chain variable fragment targeting the hemopexin-like domain decreases age-related macular degeneration . #biorxiv_cellbio.
biorxiv.org
Vitronectin is a prominent constituent of the extracelluar matrix (ECM) that plays a key role in inflammation by regulating cell adhesion, migration, and complement activation. Together with other...
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Endothelial Colony-Forming Cell Transcriptomic Profiling in CT-defined Coronary Artery Disease from the BioHEART-CT Study Implicate . #biorxiv_cellbio.
biorxiv.org
Background: Endothelial dysfunction is an early contributor to atherosclerosis. This study combined CT imaging of coronary artery disease (CAD) and patient-dervied endothelial colony-forming cells...
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Epididymal extracellular vesicles harbor and convey mRNA to sperm for transfer to zygotes #biorxiv_cellbio.
biorxiv.org
The epididymis plays a critical role in sperm maturation, including remodeling the sperm RNA payload. While small RNAs have been extensively studied in this context, the epididymal contribution to...
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α-catenin phosphorylation is actomyosin-sensitive and required for epithelial barrier functions through Afadin #biorxiv_cellbio.
biorxiv.org
Zonula adherens junctions (zAJ) are spatially proximal to tight junctions (TJ), in a superstructure known as the apical junctional complex (AJC). A key component of the AJC is a circumferential ring...
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A cytological framework of female meiosis in Arabidopsis #biorxiv_cellbio.
biorxiv.org
Female and male meiosis often differ in many aspects, such as their duration and the frequency as well as the positioning of crossovers. However, studying female meiosis is often very challenging and...
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Linking Kinetochore Attachment to Checkpoint Control: The Role of Aurora B in BubR1 Acetylation #biorxiv_cellbio.
biorxiv.org
We report here that Aurora B kinase is critical in BubR1 acetylation at K250, transducing kinetochore attachment status to spindle assembly checkpoint (SAC) activity. Aurora B phosphorylates BubR1 at...
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Disease mutations in the N-terminal extension and α 2'-helix of dyskerin do not abolish dimerization but disrupt binding to the . #biorxiv_cellbio.
biorxiv.org
The H/ACA ribonucleoprotein complex component dyskerin is essential for the biogenesis of H/ACA RNAs, including the human telomerase RNA (hTR). The N-terminal extension and α2′ helix of dyskerin are...
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Lipid Droplets of Human Carotid Atherosclerotic Plaques: Cholesteryl Arachidonate Core and Cytoskeletal Fibrotic Cover #biorxiv_cellbio.
biorxiv.org
Lipid droplets (LDs) within atherosclerotic plaques are central to cardiovascular disease, yet their molecular composition remains largely unknown. More than 20 years experiences of developing LD...
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Niche-targeted therapy via YAP/TAZ activation enhances hematopoietic regeneration #biorxiv_cellbio.
biorxiv.org
The distinctive milieu of the bone marrow (BM), known as the BM niche, supports hematopoietic stem cells (HSCs) and serves as a foundation for hematopoietic regeneration. Myeloablative stress...
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Dynamic and atypical E-cadherin-based attachments mediate melanoblast migration through confined epithelial spaces #biorxiv_cellbio.
biorxiv.org
Epithelial tissues are populated with accessory cells such as immune cells, sensory cells, and pigment-producing melanocytes, which must migrate through and intercalate between tightly adherent...
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Forward Genetics Identifies ptr-18 and Other Genes as Developmental Regulators of the Four-Cell Tail Tip in C. elegans #biorxiv_cellbio.
biorxiv.org
In C. elegans , the epidermis and its overlying extracellular matrix form a primary protective barrier, functioning as the first line of defense against environmental factors. To properly develop...
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Small shifts, big ripples: multi-omics studies reveal how ambient temperatures govern Chlamydomonas cellular responses #biorxiv_cellbio.
biorxiv.org
Photosynthetic protists known as microalgae face increasing temperatures due to global climate change. The green biflagellate alga Chlamydomonas reinhardtii is commonly found in moist soil and serves...
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Multi-nucleation in two-cell human embryos stems from spindle and metaphase plate incoherence in the first mitosis #biorxiv_cellbio.
biorxiv.org
The first embryonic division in humans is highly error-prone and a source of aneuploidies. Multi-nucleation is prevalent in two-cell human embryos, with unknown cause. Here, we live image human...
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The ancient metazoan cytoplasmic intermediate filament protein, Cilin, shapes cilia arrangement and tissue architecture #biorxiv_cellbio.
biorxiv.org
The emergence of animal multicellularity demanded novel cytoskeletal systems to support cellular architecture and tissue integrity. Cytoplasmic intermediate filaments (cIFs) are essential components...
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Characterization of membrane structures regulating primary ciliogenesis by quantitative isotropic ultrastructure imaging #biorxiv_cellbio.
biorxiv.org
The trafficking, docking, and fusion of membrane vesicles at the mother centriole (MC) are required to construct the primary cilium. Here, we determined the three-dimensional (3D) membrane ultrastr...
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