Mechanistic studies of viral neutralization typically prioritize high-affinity antibodies, relegating low-affinity binders to the sidelines. We report P5-1C8, a Class 1 SARS-CoV-2 antibody that...

Preeclampsia, a life threatening hypertensive disorder of pregnancy, is a leading cause of maternal and perinatal morbidity and mortality. Its early onset form (EO PE), requiring delivery before 34...

Lymphatic function is critical for maintaining fluid homeostasis and immune surveillance in synovial tissues, and its dysfunction is implicated in the progression of rheumatoid arthritis and osteoa...

The accurate segregation of chromosomes is mediated by kinetochores, multi-protein structures that connect centromeric chromatin to the dynamic microtubules of the spindle apparatus. Comparative...

New systematic profiling of drug effects is in urgent demand due to limitations in existing drug assessment approaches to evaluate comprehensive drug effects and distinguish heterogeneity in mixed...

Obstructive sleep apnea (OSA) and consequent intermittent hypoxia (IH) is increasingly recognized as a driver of adipose tissue dysfunction, insulin resistance, and aging. However, current in vitro...

Inside-out activation of integrins is crucial for transducing mechanical forces through the extracellular ligand-integrin-talin-F-actin axis. Extensive studies have shown that talin is the essential...

Exposure to ionizing radiation has the potential to induce significant health risks including radiation sickness and death. Here, the utility of image-based morphological profiling (IBMP) assays was...

Accumulation of senescent cells promotes ageing and age-related diseases. While senescent cells are heterogenous and increasingly persistent in vivo with age, the mechanisms underlying their hetero...

Mechanisms of matrix topography recognition are poorly understood. Here, we show that α5β1-integrin mediated fibrillar adhesions serve this function. While on planar substrates, their formation...

Background and aims: Transfer RNA (tRNA) modifications determine translation fidelity and efficiency. It occurs through the action of specific enzymes that modify the nucleotides within the tRNA...

Beige (BeAT) and white adipoctyes (WAT) reside within the same fat depots but differ in their responses to β-adrenergic stimulation. While both activate classical PKA-mediated pathways, only beige...

The primary cilium is a microtubule-based structure essential for cellular signaling, whose assembly and function depend on targeted delivery of cargo via intraflagellar transport (IFT). Intraflage...

The "brain-eating amoeba" Naegleria fowleri dwells in ponds where it normally feeds on bacteria, but if it enters the brain it can cause a deadly infection. To establish infection, N. fowleri must...

The small GTPase Rac is an essential regulator of cell shape, migration, macropinocytosis and phagocytosis. We recently reported that expression of constitutively active RacG12V is sufficient to...

Background: Heart failure with preserved ejection fraction (HFpEF) is increasingly prevalent and strongly associated with cardiometabolic comorbidities including obesity, hypertension, and metabolic...

Cellular senescence is a largely heterogeneous state of cell stress that deleteriously accumulates with age. Many types of heterogeneity in senescence have been described; however, cellular senesce...

Given the need for new tumor treatment strategies, therapies using magnetic nanoparticles and bacteria are gaining momentum. In this context, magnetotactic bacteria and magnetosomes could act as...

Cyclic stretch, generated by pulsatile blood pressure, has been identified as a pivotal regulator of vascular smooth muscle cell (VSMC) behavior and arterial wall homeostasis. Research has demonstr...

How ancient transcription factors are repurposed during evolution to drive the functional diversification of conserved organelles remains a fundamental question in biology. Although displaying a high...