David Taylor
@davidwtaylorjr
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Associate Professor / photographer of macromolecular assemblies / uncle / single dog dad / views are my own
Austin, TX
Joined September 2012
Fabulous grad student @GraceHibshman @ut_mbs @TexasScience has solved the structure of FnCas9 with its scaRNA to show how it switches roles to transcriptional repression by bypassing nuclease activation. See her talk at #CRISPR2025!
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Check out our new work @NatureComms by awesome grad student Rodrigo Fregoso Ocampo and former postdoc @jpkbravo @TexasScience @ut_mbs! Guide RNA folds into gnarly geometry to tether tiny protein domains together. Great to collaborate with @metagenomi!
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Exciting work by fantastic postdoc @kaitlynakiernan @ut_mbs @TexasScience visualizing 25 states of SpCas9! Pulled out a product release state and provides insight extremely low turnover of SpCas9 with a canonical guide RNA. Thanks to @jpkbravo for image that I could grab quick!
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Great structures from former postdoctoral fellow @jpkbravo @TexasScience, now PI @ISTAustria! Awesome collaboration with @AstraZeneca on using structure guided engineering of PsCas9 to be highly active, while retaining specificity!
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Fantastic work by postdoc @isabel_stroh @ut_mbs @TexasScience on cas12a showing a reset between cleavage events out in @MolecularCell! Another great collaboration with @palermo_lab and grad student @aakashsahha.
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Excellent preprint from @l_loeff in @MartinJinek lab on the same system with additional insights!!!.
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Especially excited that one author was a visiting summer student in the lab from a PUI!.
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Awesome work spearheaded by @jpkbravo! A DNA-guided recognition module to DNA followed by DNA handoff to a nuclease. Check out these structures! Plasmid targeting and destruction by the DdmDE bacterial defence system | Nature
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Great work by super star grad students and postdoc/new PI @GraceHibshman, Matt Hooper, and @jpkbravo @ut_mbs @TexasScience. Colab with Johnson lab and finally the other CRISPR guy @IlyaFinkelstein! Lots to see. My favorite: the SpRYmer.
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Great work by former grad student @EvanASchwartz and postdoc @jpkbravo @TexasScience @ut_mbs and Mohd Ahsan @palermo_lab in @NatureComms! Couldn’t happen without long time collaborators @RobFagerlund and @PeterFineran @otago.
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Again, this year for #UT40for40, proud to support First Generation college students like myself @TexasScience and across @UTAustin. No doubt that they will shine so much brighter than me! #UT40for40.
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Check out our new work by fabulous grad student Rodrigo @TexasScience @ut_mbs! Guide RNA folds into gnarly geometry to tether tiny protein domains together. Fun collaboration with @metagenomi! DNA targeting by compact Cas9d and its resurrected ancestor
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RT @crp_salazar: 7/7 More details in our paper. Congrats to all authors! Jurre Steens, @jpkbravo, Caglar Yildiz, Afonso Amieiro, @koestlste….
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And @jpkbravo @TexasScience made a spinning movie of the structure.
Another cool story to share before @crispr2023 - this time in collaboration with Jurre Steens, Raymond Staals & others: how cOA binding activates a CRISPR-associated protease to activate an immune signalling pathway
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Check out our new work in @ScienceMagazine. Heroic collaboration between @MIB_WUR @Ettema_lab and my fabulous postdoc @jpkbravo @TexasScience! Type III-B CRISPR-Cas cascade of proteolytic cleavages | Science
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Great SIG on sample preparation technology or more specifically Advanced topics on cool stuff at #ACA2023. Awesome speakers @NataliadeVal1, @WooyoungChoi13, Shengjiee Feng, @demarco_lab and Xueming Li! Thanks for a great session and to a great co-chair Jianhua Zhao!
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Amazing second session with @demarco_lab and Xueming Li in the SIG Sample preparation techniques at #ACA2023!.
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RT @StJudeStructBio: We have exciting news to share: the one-and-only Liz Kellogg is joining our department as Associate Member this summer….
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