Peter Fineran
@PeterFineran
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Prof. and Head of Phage-host interactions (Phi) lab. Phage defences, counter-defences, CRISPR-Cas, toxin-antitoxin. FRSNZ / James Cook Fellow
Dunedin City, New Zealand
Joined March 2017
🚨 Thrilled to share our new paper in @OxUniPress #NucleicAcidsResearch! 🎉 Phages must outsmart bacterial defences to survive. We found that the first-injected genome region is key for escaping Type I RM restriction. 📖 https://t.co/coO0Up3rK8
#Microbiology #PhageDefense
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Looking forward to it @jcornlab!
In 2026 I'm taking a sabbatical in @PeterFineran's lab @otago. I'm looking forward to learning a lot from Peter's lab and am excited to get back to my prokaryotic/viral roots! Also planning to make some trips to the rest of the Pacific and Asia. So much to look forward to!
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Type I CRISPR-Cas immunity primes type III spacer acquisition Priming by type I CRISPR-Cas aids adaptation & spacer maintenance by co-occurring type III system. Concurrent DNA & RNA-targeting minimize phage escape for population-level benefit @PeterFineran
https://t.co/Tfh80DCE9f
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All systems go: CRISPR crosstalk for enhanced immunity @CRISPRchef Previews works by @PeterFineran @alexjmeeske demonstrating CRISPR-Cas systems have unprecedented level of cooperative crosstalk between different subtypes,enabling primed spacer acquisition https://t.co/EjRcz0NGVv
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Type I CRISPR-Cas immunity primes type III spacer acquisition Priming by type I CRISPR-Cas aids adaptation & spacer maintenance by co-occurring type III system. Concurrent DNA & RNA-targeting minimize phage escape for population-level benefit @PeterFineran
https://t.co/H0RnfURnpJ
cell.com
Smith and Fineran describe how priming by type I CRISPR-Cas systems facilitates adaptation and spacer maintenance by a co-occurring type III system, which normally induces abortive infection. While...
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Check out the cool related study by Shally Margolis and Alex Meeske https://t.co/jSxCapa6cU
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Ever wondered why some bacteria have multiple CRISPR-Cas systems? Our new study led by Leah Smith shows how type I CRISPR systems can promote the acquisition and retention of new spacers into a co-occurring type III system.
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A new encyclopedic review, for plasmid lovers: https://t.co/2ANVSvbeAX We (Mapi, Eduardo and I) hope you like it!
academic.oup.com
Abstract. Plasmids play key roles in the spreading of many traits, ranging from antibiotic resistance to varied secondary metabolism, from virulence to mut
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Latest BREX story from the lab - turns out there is a nuclease after all! Congrats to Jenny Readshaw and the whole team, including wonderful collabs Barry Stoddard, Brett Kaiser and @DarrenSmithdx. @NAR_Open @NEBiolabs @DurBiol
academic.oup.com
Abstract. BREX (Bacteriophage Exclusion) systems, identified through shared identity with Pgl (Phage Growth Limitation) systems, are a widespread, highly d
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First Cut: CRISPR2025 New Zealand: Innovation and Collaboration https://t.co/IzYU535SuL Wandera et al. @PeterFineran @dsashital - A great review of the CRISPR2025 conference earlier this year
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Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism" —the 1st human to undergo custom genome editing —outgrowth of decades of NIH funded research https://t.co/XHntu0xNIZ
https://t.co/XhpAn16HaI
@NEJM
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1/10 Today in @ScienceMagazine in collaboration with @liugroup we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. https://t.co/y2DqXZzY1R
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Massive congrats to @Hazel_Sisson_ for her outstanding mahi & PhD grad yesterday. In a case of perfect timing our final paper from Hazel's PhD was published online in JBC yesterday as well! 🥳( https://t.co/ak8wuMLDVt). Please check it out, I have given a quick summary in a 🧵 👇
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Excited to announce that collaborative work between the Bostina lab (@mihnea_bostina) and PHI lab (@PeterFineran) at @otago and the Wolf lab (@HiCryoEM) at @OISTedu, has been published in Nature Communications. Congratulations all :) https://t.co/u1nIrZfRTq
nature.com
Nature Communications - The cryo-EM structure of phage φTE is presented, revealing a distinct neck topology, tail sheath baseplate organization and oligomeric state of the tape measure...
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We hope everyone is having a great first day at #CRISPR2025! As @PeterFineran mentioned there are lots of great eateries 🧑🍳 and bars 🍸 located along the Avon river - great for dinner plans tonight.
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🥳🥳🥳We are so excited to see you all today at the welcome event at 5pm at Te Pae for #CRISPR2025! If you're looking around Ōtautahi today we recommend looking at the street art, which became a feature of the city after the 2011 earthquake.
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🎉🎉🎉 one more sleep to #CRISPR2025! We are excited to see you all at the welcome event tomorrow at 5 pm at Te Pae. Some of you may have already made your way to Ōtautahi, the city has undergone a remarkable and innovative transformation since the tragic 2011 earthquake.
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T - 3 days until #CRISPR2025! We recommend checking out the trams in Ōtautahi, a good way to explore the city with a touch of nostalgia. 🚋🚋🚋
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The count down is on for #CRISPR2025, with only 5 more sleeps to go! If you're looking for things to do while in Ōtautahi we highly recommend checking out the Margaret Mahy playground in the city centre. Not just for kids even adults have been known to give the slide a whirl!
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👩🔬👩🔬 Sponsor appreciation post! 👩🔬👩🔬 Many thanks to Tome Biosciences for being a bronze sponsor #CRISPR2025.
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