Rob Fagerlund
@RobFagerlund
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Senior Research Fellow @ University of Otago | Studying CRISPR | 🇳🇿
Dunedin City, New Zealand
Joined July 2017
It's out🎉Super happy to share our story on the incredible #CRISPR-Cas I-D complex and its mysterious small subunit. Excellent work by @Tess_M_McBride & @AtomicPaparazzo. Shout-out to @davidwtaylorjr, @akhello & @PeterFineran!
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RT @ATinyGreenCell: I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract resear….
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RT @crisprmeeting: Deadline Extension for Abstract Submissions . Good news! The deadline for abstract submissions has been extended to Mond….
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RT @irmantas_mogila: Happy to share our latest story revealing how type III CRISPR-Cas ancillary effectors tactically inhibit translation t….
science.org
A prokaryotic antiviral CRISPR-Cas auxiliary effector cleaves ribosome-bound messenger RNAs to inhibit translation
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RT @NilsBirkholz: If you're after some light reading to start your week, here's a short piece I wrote for The Conversation (@ConversationED….
theconversation.com
Viruses known as ‘phages’ might become an essential tool, as antibiotic-resistant bacteria threaten conventional remedies.
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Congrats @ShaharnC 🙌🙌🙌.
Congratulations to @ShaharnC from @microtago, @otago, 🇳🇿, who was awarded an IUBMB Travel Fellowship to present her research at the @bmh2024Melb Congress in Melbourne, 🇦🇺.
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RT @NilsBirkholz: 👋🏻 I'm absolutely glee-ridden to finally see our study on the RNA- and DNA-binding anti-CRISPR repressor Aca2 published i….
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RT @mattmcneil86: Couple of recent publications from our group!!. 1) Awesome work from post-doc Will Jowsey showing how drug-resistance in….
academic.oup.com
AbstractBackground. A limited ability to eliminate drug-resistant strains of Mycobacterium tuberculosis is a major contributor to the morbidity of TB. Comp
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RT @greeninglab: In our new paper at Cell (@CellCellPress), we reveal secrets of how the third form of life, archaea, make energy. We uncov….
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RT @VHoikkala: @mfwhite2 was not wrong saying type III #CRISPR systems are “arguably more interesting”! Here we characterise Cas10s, second….
academic.oup.com
Abstract. Recognition of RNA from invading mobile genetic elements (MGE) prompts type III CRISPR systems to activate an HD nuclease domain and/or a nucleot
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RT @rafapinilla92: 🎉 Excited to share our latest paper in @cellhostmicrobe! Huge congrats to amazing co-first @FabBenz & @SarahCamara94 (in….
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RT @SarahCamara94: Excited to see our work out now in @cellhostmicrobe ! 🤩 huge team effort, kudos to everyone involved, especially @FabBen….
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RT @jpkbravo: I am thrilled to share my latest work, out today in @Nature. This project started ~18 months ago as a blueprint for my own la….
nature.com
Nature - Using cryo-electron microscopy, insights into the structural and mechanistic function of the DdmDE system that is responsible for plasmid elimination in Vibrio cholerae seventh pandemic...
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RT @jpkbravo: I'm so happy to share our SpRY-Cas9 story in its final form! Congratulations to first author @GraceHibshman - it was a great….
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RT @PeterFineran: A couple of delays, but finally managed to attend my induction as a new Fellow of the Royal Society of New Zealand @royal….
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RT @artemnemudryi: Cellular repair of DNA breaks enables editing of the human genome. Do human cells repair RNA breaks, and can we use it….
science.org
Genome editing with CRISPR RNA-guided endonucleases generates DNA breaks that are resolved by cellular DNA repair machinery. However, analogous methods to manipulate RNA remain unavailable. We show...
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RT @jpkbravo: Great to see this out! Always a great time working with the dream team @davidwtaylorjr @PeterFineran @palermo_lab @RobFagerlu….
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RT @davidwtaylorjr: Great work by former grad student @EvanASchwartz and postdoc @jpkbravo @TexasScience @ut_mbs and Mohd Ahsan @palermo_la….
link.springer.com
Nature Communications - Here, Schwartz, Bravo, and Ahsan et al. show how multi-subunit fusion proteins are arranged around a crRNA in a type III CRISPR-Cas effector to cleave target RNA. Structures...
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This was a fun collaboration with @davidwtaylorjr @palermo_lab @PeterFineran with brilliant work by first authors @EvanASchwartz @jpkbravo @Ahsan09966804 🙌.
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Further, using a combo of structural, biochemical and molecular dynamic approaches, we show new insight into how type III systems cleave RNA 😱 A must read for type III aficionados 🤓 I hope you enjoy 🎈.
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