Grace Hibshman
@GraceHibshman
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PhD Candidate in the Taylor Lab @ut_mbs š¬ Capturing molecular snapshots to understand dynamics
Austin, TX
Joined December 2019
RT @davidwtaylorjr: Fabulous grad student @GraceHibshman @ut_mbs @TexasScience has solved the structure of FnCas9 with its scaRNA to show hā¦.
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RT @jpkbravo: I'm so happy to share our SpRY-Cas9 story in its final form! Congratulations to first author @GraceHibshman - it was a greatā¦.
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RT @jpkbravo: @BKleinstiver One particularly cool aspect of this story was that we used kinetics analysis to guide cryo-EM sample prep to cā¦.
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My first story from the @davidwtaylorjr lab is online! Iām looking forward to sharing this research next week alongside @jpkbravo @crispr2023
biorxiv.org
CRISPR-Cas9 is a powerful tool for genome editing, but the strict requirement for an āNGGā protospacer-adjacent motif (PAM) sequence immediately adjacent to the DNA target limits the number of...
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RT @cijilim: Our latest publication reports the cryo-EM structures of the human PolĪ±-Primase DNA elongation complexes - .
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RT @davidwtaylorjr: Taylor lab ā¦@TexasScienceā© sweeps. Best poster ā¦ā¦@Jamie_Yellandā©, best talk ā¦@GraceHibshmanā©, best research paper ā¦@jpkā¦.
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RT @jpkbravo: It's great to be able to share the final version of this story, led by @Jamie_Yelland along with myself, @DrJoshBlack @ArlenJā¦.
nature.com
Nature Structural & Molecular Biology - Yelland et al. use yeast genetics and cryo-EM to show how 2ā²-O-methylation on a single rRNA base gates the assembly of the ribosome via regulating...
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RT @CosmicCryoEM: šØNew tool alertšØ Model Angelo - automated model building into #cryoEM maps using machine learning. Really nice results! Bā¦.
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RT @cijilim: The Lim lab's first paper is out!!! Here, we solved the cryo-EM structures of the human CST-Pola-primaā¦.
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RT @CrisprMemes: irreparable damage to this week's reading list, pls slow down @davidwtaylorjr and co.
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RT @Roisin_OBrien_: Check out our new paper on the type I-C Cascade! 5 new cryo-EM structures showing R-loop formation, PAM recognition, NTā¦.
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RT @davidwtaylorjr: Nice story by ā¦@welkerlabā©! Awesome to see SuperFi is super, super accurate in cells across many targets! Surprised toā¦.
biorxiv.org
Several advances have been made to SpCas9, the most widely used CRISPR/Cas genome editing tool, to reduce its unwanted off-target effects. The most promising approach is the development of increased...
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RT @davidwtaylorjr: Congrats to my amazing grad students @Jamie_Yelland for winning the award for best talk and @GraceHibshman for winningā¦.
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RT @davidwtaylorjr: We are looking for 1-2 postdoctoral fellows to join our group @TexasScience to study RNPs (mostly #CRISPR effectors). Pā¦.
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Could not have kicked off my graduate career with a better project! Take a look to see a never before seen loop in Cas9 and how we mutated it to create SuperFi-Cas9.
1. I am thrilled to share the accepted version of our Cas9 mismatch manuscript, now in @Nature! Hereās a (not-so) brief outline of some of the findings from our original preprint, and some VERY exciting new findings
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RT @davidwtaylorjr: Exciting story about creating a SuperFi Cas9 by mutating residues in a loop that becomes ordered to stabilize mismatcheā¦.
nature.com
Nature - Cryo-electron microscopy structures of Cas9 during mismatch cleavage provide insight into the mechanisms that control off-target effects of Cas9, which will aid in the future design of...
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RT @TexasScience: New study in @Nature today describes a super-charged version of Cas9 that makes gene editing much safer, without sacrificā¦.
molecularbiosci.utexas.edu
Gene Editing Gets Safer Thanks to Redesigned Protein
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RT @jpkbravo: 1. I am delighted to be able to share our story on the enigmatic DISARM antiphage defence system, in collaboration with @daviā¦.
biorxiv.org
In the evolutionary arms race against phage, bacteria have assembled a diverse arsenal of antiviral immune strategies. While the recently discovered DISARM (Defense Island System Associated with...
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