David MacHugh
@david_machugh
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Full Professor of Functional Genomics, Animal Genomics Group, University College Dublin.
Dublin City, Ireland
Joined November 2008
Our @CommsBio #bovineTB #eQTL #TWAS #OneHealth paper on #WorldTBDay. Excellent #ComputationalGenomics work by @jf_grady & collaborators @roslininstitute, @ETH_en. Support @agriculture_ie, @Researchirel, @UCD_OneHealth, @UCD_Conway, @ucdagfood, @ucdvetmed
https://t.co/qbnJFQqrzK
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It’s essentially a bargain bin Mary Robinson versus a pound shop Mary McAleese #rtept
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Delighted to share our review on the relevance of epigenetics for the diagnosis of bovine TB with @david_machugh and @Eamonn_Broc @ucdagfood @ucdvetmed @UCD_CHAS @UCD_Conway Funding from @Researchirel
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Our new #FunctionalGenomics study of #trypantolerance in African cattle. Great work @GillianMcHugo & collabs inc. @james_akw @kmeade11, @emmelinehill @Tom_JHall Support: @IrishResearch @ucdagfood @UCD_Research @UCD_OneHealth @GenomicsCRT @UCD_Conway
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⚡️Thrilled that #VirtualLab is published in @Nature! https://t.co/BwAsLFAeua We created a team of AI agents to mirror my Stanford lab🤖. Led by a PI agent, the AI scientists ran their own group meetings and discovered effective binders to new CoVID variants that we validated.
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1/ Tucker Carlson: “Do you think overall the COVID vaccine killed more people than it saved?” RFK Jr: “The truth is, I don’t know.” This is outrageous. I do know. The answer is: unequivocally no. 🧵
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Excited to share #AlphaGenome, a start of our AlphaGenome named journey to decipher the regulatory genome! The model matches or exceeds top-performing external models on 24 out of 26 variant evaluations, across a wide range of biological modalities.1/6
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Thread: Multi-omics sounds cool—until you actually try it. Here's are the nuances. 1/ You’ve got RNA-seq. Methylation. Proteomics. Time to “integrate” the data. But how? And why? Let’s break it down.
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Structural variants are important! However, genotyping them accurately remains a challenge. We've sequenced 120 bulls with HiFi reads to investigate the contribution of structural variants to complex traits. https://t.co/kD4OVdwnR6
biorxiv.org
Sequencing mapping cohorts with long-read technology is crucial to understand the impact of structural variants (SVs) on complex traits. Here, we obtained 4.86 terabases of HiFi reads with an average...
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Fantastic work @jf_grady - and thanks to our collaborators @LingzhaoF, @animal_eth, @icgormley, and #SteveGordon
Our new #integrative #genomics work on human #tuberculosis is now available as a preprint! Check it out below 👇 - all feedback welcome. Support from @Researchirel @GenomicsCRT @ucdagfood @UCD_Conway @animal_eth @QGG_AU
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1/ A study by Dr. Peter Hotez and colleagues estimates that over 200,000 Americans died needlessly during the COVID-19 pandemic—due to vaccine refusal fueled by disinformation. This thread breaks it down.
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Additional support @ucddublin, @UCD_CHAS, @faangomics, @ex_farm, @UCDMathStat, @EdinburghUni, and collaborators @GillianMcHugo, @emilylouise221, @animal_eth, @JGDPrendergast, @icgormley, @Eamonn_Broc, and @kmeade11
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Thrilled to share that The Farm Animal Genotype–Tissue Expression (FarmGTEx) Project perspective paper is out @NatureGenet. Thank all the authors for the efforts and supports. Looking forward to seeing amazing science coming from this initiative.
nature.com
Nature Genetics - The FarmGTEx Project aims to understand genetic control of gene activity under diverse biological and environmental contexts in domestic animals, providing a foundation for...
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Great to see the Farm Animal Genotype–Tissue Expression (#FarmGTEx) Project perspective article published in @NatureGenet. A fantastic #livestock #FunctionalGenomics project led by @LingzhaoF at @AarhusUni_int. https://t.co/HVtH4In3i5
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Gratz to #KevinDaly @ucdagfood, @UCD_CHAS, and @UCD_Conway for this exciting @ScienceMagazine #paleogenomics and #PopulationGenomics study on the origins and dispersal of domestic sheep. This work was led by @brad_dan @tcdgenmicro. https://t.co/6ESNsBQ2ai
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I’ve seen my share of anti-science activists. But few are as dangerous as Vandana Shiva. She brands herself as a "food sovereignty" advocate. In reality? She’s an activist spreading misinformation about GMOs, pesticides, and modern agriculture. Here’s the real story 🧵: 1/
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🧵1/2 The Guardian columnist who wrote yesterday's op-ed about Trump's executive order reached out to me Friday morning for some "expert commentary." TLDR: I provided her with plenty of scientific evidence/argument/detailed commentary in answer to her questions about Trump's
whitehouse.gov
By the authority vested in me as President by the Constitution and the laws of the United States of America, including section 7301 of title 5, United
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Delighted to see our new paper out in Nature https://t.co/4dOTqJT2vS
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