David MacHugh
@david_machugh
Followers
764
Following
3K
Media
146
Statuses
2K
Full Professor of Functional Genomics, Animal Genomics Group, University College Dublin.
Dublin City, Ireland
Joined November 2008
Our @CommsBio #bovineTB #eQTL #TWAS #OneHealth paper on #WorldTBDay. Excellent #ComputationalGenomics work by @jf_grady & collaborators @roslininstitute, @ETH_en. Support @agriculture_ie, @Researchirel, @UCD_OneHealth, @UCD_Conway, @ucdagfood, @ucdvetmed
https://t.co/qbnJFQqrzK
1
11
23
Great to finally settle the debate of who’s better, Ronaldo or Troy Parrott
3
59
1K
Gratz to @jf_grady, Dr John O'Grady, on passing his @ucddublin, @ucdagfood PhD viva today with no examiner corrections—a rare feat! 😀 Thx: @colmr @PatLonerganUCD #AlexBagnato @LaStatale (U of Milan) Support: @Researchirel @GenomicsCRT @UCD_Conway @agriculture_ie @UCD_OneHealth
2
3
12
It’s essentially a bargain bin Mary Robinson versus a pound shop Mary McAleese #rtept
0
0
3
Delighted to share our review on the relevance of epigenetics for the diagnosis of bovine TB with @david_machugh and @Eamonn_Broc @ucdagfood @ucdvetmed @UCD_CHAS @UCD_Conway Funding from @Researchirel
0
3
8
Our new #FunctionalGenomics study of #trypantolerance in African cattle. Great work @GillianMcHugo & collabs inc. @james_akw @kmeade11, @emmelinehill @Tom_JHall Support: @IrishResearch @ucdagfood @UCD_Research @UCD_OneHealth @GenomicsCRT @UCD_Conway
https://t.co/duwHatyh2A
1
4
16
⚡️Thrilled that #VirtualLab is published in @Nature! https://t.co/BwAsLFAeua We created a team of AI agents to mirror my Stanford lab🤖. Led by a PI agent, the AI scientists ran their own group meetings and discovered effective binders to new CoVID variants that we validated.
24
245
968
1/ Tucker Carlson: “Do you think overall the COVID vaccine killed more people than it saved?” RFK Jr: “The truth is, I don’t know.” This is outrageous. I do know. The answer is: unequivocally no. 🧵
589
2K
18K
Excited to share #AlphaGenome, a start of our AlphaGenome named journey to decipher the regulatory genome! The model matches or exceeds top-performing external models on 24 out of 26 variant evaluations, across a wide range of biological modalities.1/6
14
211
908
Thread: Multi-omics sounds cool—until you actually try it. Here's are the nuances. 1/ You’ve got RNA-seq. Methylation. Proteomics. Time to “integrate” the data. But how? And why? Let’s break it down.
3
68
459
Structural variants are important! However, genotyping them accurately remains a challenge. We've sequenced 120 bulls with HiFi reads to investigate the contribution of structural variants to complex traits. https://t.co/kD4OVdwnR6
biorxiv.org
Sequencing mapping cohorts with long-read technology is crucial to understand the impact of structural variants (SVs) on complex traits. Here, we obtained 4.86 terabases of HiFi reads with an average...
1
3
6
Fantastic work @jf_grady - and thanks to our collaborators @LingzhaoF, @animal_eth, @icgormley, and #SteveGordon
Our new #integrative #genomics work on human #tuberculosis is now available as a preprint! Check it out below 👇 - all feedback welcome. Support from @Researchirel @GenomicsCRT @ucdagfood @UCD_Conway @animal_eth @QGG_AU
0
2
6
1/ A study by Dr. Peter Hotez and colleagues estimates that over 200,000 Americans died needlessly during the COVID-19 pandemic—due to vaccine refusal fueled by disinformation. This thread breaks it down.
75
315
1K
Additional support @ucddublin, @UCD_CHAS, @faangomics, @ex_farm, @UCDMathStat, @EdinburghUni, and collaborators @GillianMcHugo, @emilylouise221, @animal_eth, @JGDPrendergast, @icgormley, @Eamonn_Broc, and @kmeade11
0
0
1
Thrilled to share that The Farm Animal Genotype–Tissue Expression (FarmGTEx) Project perspective paper is out @NatureGenet. Thank all the authors for the efforts and supports. Looking forward to seeing amazing science coming from this initiative.
nature.com
Nature Genetics - The FarmGTEx Project aims to understand genetic control of gene activity under diverse biological and environmental contexts in domestic animals, providing a foundation for...
0
6
14
Great to see the Farm Animal Genotype–Tissue Expression (#FarmGTEx) Project perspective article published in @NatureGenet. A fantastic #livestock #FunctionalGenomics project led by @LingzhaoF at @AarhusUni_int. https://t.co/HVtH4In3i5
1
7
10
Gratz to #KevinDaly @ucdagfood, @UCD_CHAS, and @UCD_Conway for this exciting @ScienceMagazine #paleogenomics and #PopulationGenomics study on the origins and dispersal of domestic sheep. This work was led by @brad_dan @tcdgenmicro. https://t.co/6ESNsBQ2ai
0
3
11