1/ After years of watching the spread of disinformation on this platform, here’s what I’ve learned….🧵

Chikungunya up in Singapore: 2025 cases already exceed all of last year. Mosquito risks climbing—vector control and public vigilance must step up now. #Chikungunya #UrbanHealth.Ref:

Join millions who have switched to Grok.

US Alert: Travel-linked human case of screwworm confirmed in Maryland. No further spread yet—but surveillance of livestock and wound-care vigilance are essential. #OneHealth #Screwworm.Ref:

Alert: Surge in Vibrio vulnificus cases—“flesh‑eating” bacterial infections—reported along Gulf Coast. High risk for wound exposures; clinicians and the public must remain vigilant. #Vibrio #WaterborneIllness.Ref:

New Mexico alert: First human plague case of 2025 confirmed in Valencia County. Wild rodent reservoirs persist—ensure caution when camping or handling pets outdoors. #Plague #Zoonosis.Ref:

10/ In summary: FM reflects both a gap in conventional care and the risks of drifting into pseudoscience. Patients deserve both:.✅ Time, empathy, lifestyle focus.✅ Rigor, evidence, validated science. —@IntegralAnswers.

9/ Bottom line:.Functional Medicine is a hybrid. 🌱 Strong on lifestyle & patient engagement. ⚠️ Weak on evidence for many tests & treatments. Its future depends on whether it can shed pseudoscience & align with rigorous science.

8/ Why it’s popular:.Patients want more than 10-minute visits. They want root cause explanations for chronic illness. FM offers time, attention, and a “narrative of healing”—even if some tools rest on shaky science.

7/ Research:.📍 Cleveland Clinic’s Center for Functional Medicine reported improved patient-reported outcomes. But critics note: selection bias, lack of controls, reliance on subjective measures.

6/ Limitations:.❌ Reliance on unvalidated tests.❌ “Diagnoses” like adrenal fatigue not recognized in mainstream medicine.❌ Heavy supplement/detox regimens.❌ Thin evidence base (few RCTs).

5/ Strengths of FM:.✔️ Lifestyle emphasis (diet, exercise, sleep, stress).✔️ Systems approach: connects health across a lifetime.✔️ Longer visits & deeper engagement.✔️ Patient empowerment

4/ Tests commonly used in FM:.✅ Standard: cholesterol, HbA1c, thyroid, celiac serology, vitamin D.⚠️ Controversial: IgG “food sensitivity” panels, salivary cortisol, stool microbiome mapping, organic acids — most lack validation.

3/ Core tools of FM include:.🔹 Detailed personal “timeline” & health narrative.🔹 The “Functional Medicine Matrix”.🔹 Nutrition & lifestyle interventions.🔹 Extensive lab testing (sometimes controversial)

2/ Functional Medicine seeks to treat the root causes of disease, not just symptoms. It emphasizes long visits, lifestyle changes (diet, sleep, stress, exercise), and patient engagement.

What is Functional Medicine?.The Institute for Functional Medicine (IFM) calls it a “systems biology” approach to chronic illness. Founded in 1991 by Jeffrey Bland, it now certifies ~2,500 practitioners worldwide. Let’s unpack the facts. 🧵

10/ 🔁 CTN-1101 follow-up (registry).Real-world data: post-trial graft choices shifted toward haplo; core efficacy differences in 2-yr PFS remain modest. Link:

9/ 🧲 Magnetic nanoparticles + MSCs (mostly neutral/beneficial).Labeling showed no cytotoxicity and enhanced anti-inflammatory function; not a silver bullet. Link:

8/ 🩸 HSC numbers aren’t boosted by more “niche”.Nature paper shows systemic + local limits (incl. TPO) constrain HSC counts despite more niche availability. Link:

7/ 🧬 Safer integration analysis for gene/cell therapy.MELISSA statistically scores vector integration sites and clone fitness; applied to HSPC/MSC data + trial datasets. Link:

5/ 💇‍♂️ hUC-MSC exosomes for AGA (preclinical).Exosomes activated Wnt/β-catenin signaling; improved follicle metrics in models. Link:

4/ 🫙 sEVs aid colonic healing (preclinical).MSC small EVs improved anastomotic repair in vivo; pro-healing transcriptomic and metabolic shifts. Link: