Now out @BloodJournal: Ferroptosis regulates hemolysis in stored RBCs. We identify STEAP3 (p53 target) as a key driver of stored RBC hemolysis by Fe-dependent lipid peroxidation. @grkeele @jameszimring @bstockwell Gary Churchill @jacksonlab @GrierPage .

RT @edchuong: I’m excited to share our latest study led by.@GiuliaPasquesi out today in @CellPressNews , uncovering a new way transposons h….

Blood is a window on systems health. Great work from Higgins and colleagues @Nature shows that stability or setpoints in complete blood count parameters in 10s of thousands of patients over 20 years is associated with clinical risk and all cause mortality.

RT @CU_BMG: Congratulations to @FCendali in the @dalessandrolab for receiving the 2024 Hematology Pathway Inclusion award for the top scori….

RT @CUHematology: We are loving Day 3 of #ASH24 with Gaslamp District of San Diego as backdrop (😍). Evolving #hematology therapies & patien….

RT @whitefishlab: An unexpected paradox of aging and cancer. It has been great watching this story evolve over the past few years but glad….

RT @bloodandtime1: Just in time for #ASH24, our latest is online:.

RT @kadzuis: The central message behind our two recent papers in @NatMetabolism @MolSystBiol. •• If you can’t identify it with XCMS-METLIN,….

RT @DanPollyea: Thanks for highlighting this really important effort to develop new prognostic criteria for new therapies. Have to do this….

RT @PhilSpinellaMD: First pediatric subject enrolled today at Le Bonheur Children's hospital in the first traumatic bleeding platform trial….

RT @EricTopol: The human proteomic revolution proceeds with high-throughput assessment, AI analytics, correlation with health and disease,….

The Human Cell Atlas. Important work to map the 30-37 trillion cells in the human body. Hopefully these efforts will not completely ignore red blood cells, up to 83% of the cells in this count.

RT @bstockwell: Our perspective in @ScienceMagazine on #Ferroptosis—#disease perils and #therapeutic promise writt….

Same!.

Interesting study! Missense PLA2G6 SNPs are common in blood donors and are linked to RBC hemolysis from our study here - . Another link between RBC hemolysis and kidney disease?

Highly Cited Researchers | Clarivate - Honored to be in such a shortlist and good company!.⁦@CUAnschutz⁩ ⁩ ⁦@CU_BMG⁩ ⁦@CUHemeOnc⁩ ⁦@DanPollyea⁩

My Twitter/X feed has turned into a mix of political propaganda/brainless videos, drowning out the interesting posts that originally attracted me to this platform. Like many others, I am giving it a good old try to BlueSky social. I will likely slowly discontinue my presence here

kudos to the co-authors listed above, and @SpitalnikSteven @travisnemkov @EricJayEarley Mike Busch and team @vitalant; @nih_nhlbi for the support to the REDS RBC Omics study @AABB @ASH_hematology @TransfusionNews.

Once again, the study of blood donors and transfusion medicine is not only immediately relevant per se, but allows us to unravel some novel fundamental biology of relevance to erythrocyte metabolism in health and disease, but also potentially to all other cell systems.

Death by iron-dependent lipid peroxidation in a cell that harbors 66% of bodily iron is no surprise. Yet here we show that ferroptosis can be triggered by biochemical events in the absence of de novo gene expression in the mature RBC, that lacks nuclei and organelles.

The study expands on the rapidly growing field of ferroptosis (special thanks to @bstockwell) by reconciling historical hallmarks of erythrocyte non-apoptotic cell death or eryptosis with ferroptosis.