Greg Keele
@grkeele
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Postdoc @jacksonlab
Chapel Hill, NC
Joined September 2010
Big thanks to a fantastic scientific village. In particular, Gary Churchill @jacksonlab, Jim Zimring @MedicineUVA, and @dalessandrolab!.
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Excited to share a new pre-print!. Genetic architecture of the red blood cell proteome in genetically diverse mice reveals central role of hemoglobin beta cysteine redox status in maintaining circulating glutathione pools
biorxiv.org
Red blood cells (RBCs) transport oxygen but accumulate oxidative damage over time, reducing function in vivo and during storage—critical for transfusions. To explore genetic influences on RBC...
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RT @dalessandrolab: Now out @BloodJournal: Ferroptosis regulates hemolysis in stored RBCs. We identify STEAP3 (p53 target) as a key driver….
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RT @dalessandrolab: Blood donors offer a window into "healthy" aging. Now out @AgingCell, we report that arginine metabolism in >13k blood….
onlinelibrary.wiley.com
Reisz et al. examined age-related changes in erythrocyte metabolism using 15,700 specimens from 13,757 individuals across four cohorts, including healthy donors and sickle cell disease patients. The...
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RT @dalessandrolab: Thanks to all involved, Julie A Reisz Haines @travisnemkov @CUAnschutz, @SpitalnikSteven Eldad Hod @Columbia, @jameszim….
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RT @dalessandrolab: RBCs from poor storing mice make good storing RBCs store poorly as well. A cellular cross-talk, a "good apple, bad appl….
onlinelibrary.wiley.com
Background The cellular and molecular changes during red blood cell (RBC) storage that affect posttransfusion recovery (PTR) remain incompletely understood. We have previously reported that RBCs of...
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RT @WilliamValdar: Easy reporting of gene-by-treatment (GxT) or gene-by-environment (GxE) effects on RNA-Seq or other molecular count pheno….
biorxiv.org
Genetic variation can modulate response to treatment (G×T) or environmental stimuli (G×E), both of which may be highly consequential in biomedicine. An effective approach to identifying G×T signals...
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RT @caina89: Quantgen folks looking for next event after @icqg2024: Registration is open for @GordonConf on Quantgen and genomics (16-21 Fe….
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RT @dalessandrolab: Excited to share our recent study on Biological and Genetic determinants of Red Blood Cell Glycolysis, now out @Cell_Me….
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RT @dalessandrolab: What do RBCs without mitochondria do with carnitine? Now out in @BloodJournal. I am finally ready to share the backstor….
ashpublications.org
Key PointsCarnitine pools in stored human and murine RBCs are regulated by genetic polymorphisms in the SLC22A16 and SLC22A5 transporters.Carnitine pools f
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RT @dalessandrolab: Preprint alert: Ferroptosis regulates hemolysis in stored murine and human red blood cells. If there is a paper from ou….
biorxiv.org
Red blood cell (RBC) metabolism regulates hemolysis during aging in vivo and in the blood bank. Here, we leveraged a diversity outbred mouse population to map the genetic drivers of fresh/stored RBC...
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RT @dschweppe1: Chelsea's latest in collaboration with @joselmcfaline and @GarciaLabMS's groups (thanks!) defines differential remodeling o….
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RT @dalessandrolab: Check out the latest version of our paper on genetic and biological determinants of (RBC) glycolysis. Peer review is de….
biorxiv.org
Mature red blood cells (RBCs) lack mitochondria, and thus exclusively rely on glycolysis to generate adenosine triphosphate (ATP) during aging in vivo and during storage in vitro in the blood bank....
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RT @CzerwinsMarcin: Another interesting discovery from @dalessandrolab: L-carnitine as an important factor in RBC metablism. Supplementati….
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RT @dschweppe1: #TeamMassSpec We're recruiting postdocs to work on new methods to map proteome remodeling due to chemical perturbations, ag….
schweppelab.org
Chemoproteomics
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RT @dalessandrolab: Lessons from Blood Donors: your blood not only saves lives, but it is teaching us more about human biology at a scale t….
news.cuanschutz.edu
CU Anschutz Researchers Identify New Biomarker in Quality of Blood Donations
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RT @SimingZhao06: Glad to see our paper, with @xinhe2 @mstephens999 @wescrouse Sheng and Kevin, is out today at @NatureGenet! https://t.co/….
nature.com
Nature Genetics - Causal-TWAS (cTWAS) is a statistical framework that adjusts for genetic confounders in transcriptome-wide association studies. Application of cTWAS on common traits leads to...
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RT @carynwillis94: Happy to share two new preprints from our group at @RTI_Intl and collaborators covering DNA methylation and gene express….
medrxiv.org
Excessive alcohol consumption is a leading cause of preventable death worldwide. Neurobiological mechanisms associated with alcohol use disorder (AUD) remain poorly understood. To further understand...
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