ben
@ben_aip
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Biochemist, de novo protein design, protein engineering, chaperones. innovating better biologics.
Boston
Joined January 2019
Excited to share that a de novo designed miniprotein that myself, @bahl_lab, and @frankteets created during my post-doc is now in humans! The miniprotein is a Nectin-4 binding radiopharmaceutical being developed by Aktis Oncology.
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So happy and relieved that this is now out in https://t.co/L6Gip0hieI! Thanks to all authors esp Tri, @ShahmoraLab for help w revisions, and mentors @BarmadaLab, @pappassa, and @BillDauerNeuro for continued support. Also thanks to the reviewers who had thoughtful suggestions.
Excited to share my thesis work! Using super-resolution microscopy and a new HaloTag-Nup107 mouse line, we find that 1) NPC biogenesis is upregulated during neuronal maturation and that 2) torsinA is essential for normal localization and assembly kinetics of neuronal NPCs. (1/N)
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We’re excited to share our preprint where we show, for the first time, the atomically accurate design of VHH antibodies!
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LigandMPNN preprint: https://t.co/3DZWIbpe9E LigandMPNN inference code + model weights (including ProteinMPNN, SolubleMPNN etc):
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just a quick reminder to join us tonight for our first meeting of 2024!
We're excited to have @sarahgurev and @nooryoussef03 kick off our 2024. Join us January 10th @ 7pm EST in Cannon Room @harvardmed "Using the past to predict the future: unsupervised early warning of viral antibody escape for the design and testing of variant-proof therapeutics"
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We have updated our preprint with @CasperGoverde and @befcorreia on the design of soluble membrane protein analogues! We have now included proof of principle designs to show that our analogues can be functionalized via sequence grafting. https://t.co/TBIdWf24JK
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The AI4PD Instructors and Organizers arrived to Puerto Varas, getting ready for the start of the workshop tomorrow! @fengel97 @ben_aip @HelenEisenach @bahl_lab @sokrypton @SusanaVazTor
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for the folks who missed out on seeing @AlissaHummer's fabulous seminar live this week, you can check out the recording 👇 https://t.co/qJ5WDdnnEj thanks again @reed_frerichs and @markcastleman from @IntelIgnite for stopping by and supplying the brain fuel (🍕&🍺) for the evening
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thank you @jaredstaylor and @SliceofHC for the opportunity to share our story! it was a delight to discuss the work we're doing at @AI_Proteins Proteins to create next-gen #miniprotein therapeutics to help patients
our President, CSO and co-founder Chris Bahl @bahl_lab recently joined the @SliceofHC podcast to discuss the future of #miniprotein therapeutics with Jared Taylor @jaredstaylor you can check out the full episode 👇 https://t.co/nFEO7sYDA4
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🎉 I'm thrilled to announce the formation of @AI_Proteins Scientific Advisory Board, an exceptional group of scientists, physicians, and industry veterans https://t.co/2pkESs1cVh we're another step closer bringing miniprotein medicines to help patients as quickly as possible 🚀
businesswire.com
AI Proteins, Inc., a growing biotechnology company that utilizes computational de novo protein design to create novel therapeutic miniproteins, today announc...
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Excited to share my thesis work! Using super-resolution microscopy and a new HaloTag-Nup107 mouse line, we find that 1) NPC biogenesis is upregulated during neuronal maturation and that 2) torsinA is essential for normal localization and assembly kinetics of neuronal NPCs. (1/N)
TorsinA is essential for the timing and localization of neuronal nuclear pore complex biogenesis https://t.co/IU3toVCgtw
#biorxiv_cellbio
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get excited for our next seminar! Wednesday, April 12th at 7pm EDT by @HWaymentSteele "Understanding and discovering fold-switching proteins by combining AlphaFold2 and sequence clustering" A big thanks to @FlagshipPioneer's Pioneering Intelligence initiative for sponsoring
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Today we're making RF Diffusion, our guided diffusion model for protein design with potential applications in medicine, vaccines & advanced materials, free to use. The software has proven much faster and more capable than prior protein design tools. https://t.co/lhkhBZNzYc
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very excited to share the amazing work done by our own @ben_aip back when he was a postdoc with @bahl_lab at @ipiproteins
presented on March 3rd 2021 by Ben Meinen @ben_aip "Rational de novo design of disulfide-rich miniprotein agonists and antagonists for family B G-protein coupled receptors" https://t.co/jiqWV8BwHc
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we're thrilled to have @nickpolizzi_ in #Boston and to host him as our first speaker of 2023! "Designing ligand-binding proteins from scratch" 7pm EST on January 11th 2023 in the Cannon Room of Building C on the @harvardmed quad see https://t.co/CTrYxo8zIV for details
bpdmc.org
introduction and membership Boston Protein Design and Modeling Club (BPDMC) is a community of computational protein engineers and modelers from both academia and industry. While we are based in...
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exciting news to share: we are going to resume having in-person meetings in 2023! (we will continue to stream all seminars for our community members outside of Boston) stay tuned for details, which will be posted to our new website
bpdmc.org
introduction and membership Boston Protein Design and Modeling Club (BPDMC) is a community of computational protein engineers and modelers from both academia and industry. While we are based in...
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inspired by some of our work on AF2Rank (showing AF can be used to denoise template inputs) and RFdiffusion, I tried hacking AlphaFold to be a diffusion model for generating backbones. 😎
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ProteinMPNN paper: https://t.co/BLPg2XdmYE Github: https://t.co/ECb926ECsu Colab notebook: https://t.co/y6x6GZwYj3 HuggingFace notebook: https://t.co/lbXXAKWTHK Hallucinating symmetric protein assemblies paper: https://t.co/cBoI8RuK5Q Thanks to all collaborators!
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I'm excited to share this opportunity to join us at @AI_Proteins! We're looking for an experienced pharmacologist to help lead our efforts to characterize de novo miniprotein therapeutics https://t.co/yeTYYY6aRG
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