Cesar Ramirez-Sarmiento @cesarramirez.bsky.social
@cxarramirez
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Protein Science Generalist. PI @pb3lab. Views: my own.
P. Univ. Católica de Chile
Joined September 2009
Registrations to the 2025 AI for Protein Design, sponsored by @EMBO, @RosettaCommons, @ProteinSociety, @Kurabiotech and @AI_Proteins, being held in Puerto Varas, Chile, are now OPEN! More info, deadlines & attendee selection process: https://t.co/lPFbHV7qi3
#EMBOaiProteinDesign
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1/2 🧵 We're learning how to use BindCraft at the Center for Genomic Sciences in Mexico 🇲🇽 BindCraft achieves an experimental success rate of 10–100%, compared to the 0.2% for traditional approaches 🔥 When people talk about drug design, they're actually referring to this.
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BoltzGen is coming to @benchling. We had a chance to sit down with the model co-creator @HannesStaerk to hear how BoltzGen was built, why transparent validation matters, and what sets this model apart. https://t.co/4OB2Axd9lC
benchling.com
Go "Behind the Model" with BoltzGen co-creator Hannes Stärk. Learn how Benchling and MIT built and validated BoltzGen for generative protein design, ensuring transparency and rigor in scientific AI.
Excited to release BoltzGen which brings SOTA folding performance to binder design! The best part of this project has been collaborating with many leading biologists who tested BoltzGen at an unprecedented scale, showing success on many novel targets and pushing its limits! 🧵..
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🚀🚀David Baker paper from @Nature is here👇👇 What if we could design calcium-selective ion channels from scratch by precisely positioning atoms at their selectivity filters?@UWproteindesign "Bottom-up design of Ca2+ channels from defined selectivity filter geometry" •
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🚀🚀David Baker paper from @CellBiomat is here👇 What if we could design entirely new proteins that self-assemble into customizable materials on command?@UW "Stimuli-triggered formation of de novo-designed protein biomaterials" • Protein-based biomaterials offer advantages
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Our latest collaborative paper with David Baker's lab is now live in Cell Biomaterials (@CellBiomat, Cell Press)! Check out "Stimuli-triggered Formation of De Novo-designed Protein Biomaterials"! 🔓 : https://t.co/GSSJPePbgX
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🚀🚀David Baker preprint is here!! What if we could test hundreds of designed proteins per day instead of waiting weeks for just a few dozen?@UW @biorxivpreprint "Accelerating protein design by scaling experimental characterization"(v2) • Recent advances in computational
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Bonus track: the @TEDFellow film came out with a fascinating interview with Lily James Olds for @TEDTalks Daily, talking about science, arts, AI, protein science, and some of the leading companies in the field like @AI_Proteins founded by @bahl_lab
https://t.co/ihdT7V2BKp
spotify.link
TED Talks Daily · Episode
“We just don’t have a thousand years to wait. We have to do it now.” In his 2025 Fellow Film, protein engineer @cxarramirez of @pb3lab shows how AI is helping scientists design new proteins to fight disease, reduce pollution and reshape the future of humanity:
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Thank you, @TEDFellow, for showcasing our research and education efforts in protein design in LatAm! This is all possible thanks to @iibm_uc @ibiochile @ucatolica @uc_chile @ANID_Chile @min_ciencia @inach_gob @EMBO @ICGEB @HomeworldBio and many collaborations around the world!
“We just don’t have a thousand years to wait. We have to do it now.” In his 2025 Fellow Film, protein engineer @cxarramirez of @pb3lab shows how AI is helping scientists design new proteins to fight disease, reduce pollution and reshape the future of humanity:
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Are you passionate about how #enzyme_catalysis can be used for #sustainable_synthesis🌿🌎? Check out the open positions (PhD & Postdoc) in my lab and join a great team of enzyme lovers @DCBPunibern! 👉 https://t.co/5o34NP2vBR 👉 https://t.co/gWeAu2BceL 📣 Please spread the word!
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Intern openings for our GenAIR team are up! Exciting projects lined up across GenAI, including some cool ideas in the protein space! If you want to work with us apply at the link below, and if you have questions send them to genair-openings@nvidia.com.
📢 The Fundamental Generative AI Research (GenAIR) team at NVIDIA is looking for outstanding candidates to join us as summer 2026 interns. Apply via: https://t.co/DARXlEpmUg Email: genair-openings@nvidia.com Group website: https://t.co/mWY7utKK1m 👇
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🚨 new paper in @ScienceTM 🚨 Here, we describe and evaluate a "best-of-both-worlds" vaccine technology platform that combines the benefits of mRNA vaccines and computationally designed protein nanoparticle immunogens: https://t.co/E7jl0fYInN.
science.org
Genetic delivery of designed protein nanoparticles displaying the SARS-CoV-2 RBD elicits potent neutralizing antibody and CD8 T cell responses.
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🤯🤯 A Paper from David Baker labs is here!!👇 Can we control immune cell behavior by precisely tuning how cytokine receptors are positioned in space relative to each other?@UWproteindesign @biorxivpreprint "Geometric Tuning of Cytokine Receptor Association Modulates Synthetic
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🚀🚀A new @biorxivpreprint from David Baker is here👇 What if we could design thousands of protein tools to precisely control the abundance of any protein inside living cells, moving beyond the limitations of current genome editing to achieve true proteome editing?@UW
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📢📢David Baker paper from @biorxivpreprint is here!! What if we could create entirely new immune signaling molecules that don't exist in nature by mixing and matching receptor binding components?@UWproteindesign "High-Throughput De Novo Protein Design Yields Novel
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🚀🚀 Sergey Ovchinnikov (@sokrypton) paper is here!! What if protein structure prediction models could be repurposed to design entirely new proteins by exploiting their tendency to hallucinate plausible structures?@MIT @biorxivpreprint "Protein Hunter: exploiting structure
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TVN anuncia maratón de 31 Minutos por televisión abierta tras su exitoso paso en el Tiny Desk
adnradio.cl
Revisa acá cuándo y cómo ver esta inédita emisión.
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Excited to share Caliby 🐈, our new model for structure-conditioned sequence design! Caliby is a Potts model-based sequence design method that can condition on structural ensembles. We use this to average out non-structural signal (e.g. evolutionary bias) learned by models 🧵1/N
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University of Geneva – Are you interested in a #PhD in #LifeSciences? Applications now open Fully-funded #PhD positions available to bright and motivated #Master students! Apply by Nov 1st 2025, visit: https://t.co/WMxhKIIyjw
@UNIGEnews @sciences_UNIGE @LifeSciencesPh1
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What does it take to shape the future? 🌍 🎥 Season 2 of the TED Fellows Film Series is here — featuring innovators turning waste into bioplastics, scientists using satellites to fight hunger, and artists revealing untold stories from around the world. Watch the first 5 films
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🚀🚀David Baker paper is here from @Nature How can scientists engineer proteins to rapidly turn off cellular signaling, like having a molecular "kill switch" for cytokines? @UWproteindesign "Design of facilitated dissociation enables timing of cytokine signalling" • Protein
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