MK-6240 is a PET imaging agent that can discern subtle early-stage Alzheimer's brain changes. How does it interact with Alzheimer's tau filaments at a high-resolution molecular level? 🔬⚡Read on and check out our bioRxiv article:

The next discovery in treating brain diseases may come from tiny cell structures. David Sanders, Ph.D., studies biomolecular condensates and their role in Alzheimer’s/ALS—work that earned him the @NIH Director’s New Innovator Award. Explore more: https://t.co/NgiJFolBDA #UTSWMed

@MDiamond_Lab for recruiting me to this wonderful institution; @brangwynnelab for taking a chance on a postdoc with a psychology degree; @ShahmoraLab for co-leading our remarkable group of scientists; and our amazing lab members and @NIH for believing in our high risk research!

Returning to Science Twitter briefly to thank the UTSW newsroom for their kind story on my New Innovator award. Humbling experience. A few thank yous to follow, as most haven't switched to the "other" place. :)

A UT undergrad wrote a very interesting paper that uses neural cellular automata to solve some of the Abstraction and Reasoning Corpus (ARC) AGI benchmark problems. @TexasScience https://t.co/bi4FRS2WSi

1/8 Cryogenic electron tomography (cryoET) is a revolution already in motion! @MishaKudryashev argues that in situ structural biology is exploding, forcing us to rethink cells, molecules, and collaborations: https://t.co/5HdGNOxFmN Let’s unpack that 👇 #CryoET #StructuralBiology

We have a preprint for you EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer By Elena Vazquez-Sarandeses, Vasya @v_mikirtumov Jeff Noel&Oli Daumke https://t.co/kq450wTJkV

Building atomic models to cryo-EM maps of huge molecules is intimidating: crowded, uncertain copy numbers, variable resolution ... @theliulab and team show how cross-linking MS can be used to build novel models of unknown complexes, like a giant virus❄️ ❄️ https://t.co/WZXDTOJOKY

Our manuscript for remote focus stabilization for oblique plane microcopy is online: https://t.co/pF6bO0IwKU

Last night my brilliant friend with 20 years of expertise in Neuroscience including a decade at NIDA was fired because she was recently promoted for her outstanding performance and it triggered the probation period. This is not making NIH more efficient, this is not making us

"Don't be afraid!" Randy Schekman says that the most successful scientists are willing to take risks. He uses 2024 chemistry laureate David Baker as an example of how embracing risk can lead to significant rewards. Before Baker transitioned to researching structural biology he

Hi, it’s nice to meet you. I am a #brain scientist. My life's mission is to prevent #Alzheimer’s disease and related dementias...or to contribute enough puzzle pieces so that someone else can unlock the mysteries of disease. I might take a day off, but if I’m being honest, maybe

Interesting in learning to process cryo-ET data in the latest version of Warp? I'll be running a workshop on April 22nd in central London, UK details+registration: https://t.co/s3k1mWyB4A Hope to see you there!

The self driving multi-scale microscope from @Daetwyler_St is out. It can image a whole zebrafish embryo longitudinally and follow a region of interest with high resolution. We use it to study immune-cancer cell interactions. https://t.co/AGdAfbGm0N

Excited to share our new preprint "Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons" https://t.co/JiPta0kDGg We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during vesicle fusion ❄️🔬⏱️

We performed subtomogram averaging on complexes from >3 MDa to ~200 kDa, including 80S ribosomes, Rubisco, clathrin, microtubules, ATP synthase photosystem II, and nucleosomes. Most density maps achieved sub-nanometer resolution!🔬✨ #CryoET #StructuralBiology #VisualProteomics

Our experience with #alphafold3 🤖 (code recently released) and some of our most recent #cryoEM 🔬 structures (thread below) https://t.co/SmX8i15Zwa https://t.co/hwJUlkwhye

HHMI Investigator Joshua Mendell (@Mendell_lab) at @UTSWMedCenter helped discover that tRNAs play a role in stabilizing or degrading some mRNAs during translation. Their findings could one day help tailor vaccines and disease therapies. Learn more: https://t.co/GMFii1nJQ9 👈

I’m thrilled to share this story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu! We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation. https://t.co/gXsJo1Mc1B

🚨 Our story on the TSC:WIPI3 lysosomal-recruitment complex is now live in @ScienceAdvances . Equal-first co-authors @LuptonCJ & @sci_laura. Work lead by @Dr_Ellisdon. Funding from @DeptofDefense & @arc_gov_au. https://t.co/8JYixZHiQ2