Barmada Lab
@BarmadaLab
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Barmada lab @UMich. We study cellular mechanisms underlying ALS/FTD & RNA biology with focus on neurodegeneration. (group-run account)
Ann Arbor, MI
Joined May 2020
New preprint from our and @BillDauerNeuro labs, also with @pappassa! @suminkim28 characterized neuronal NPC biogenesis and implicates mislocalized/delayed NPC assembly in DYT1 dystonia. See tweetorial below ⬇️.
Excited to share my thesis work!. Using super-resolution microscopy and a new HaloTag-Nup107 mouse line, we find that 1) NPC biogenesis is upregulated during neuronal maturation and that 2) torsinA is essential for normal localization and assembly kinetics of neuronal NPCs. (1/N).
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Our work on matrin3 is now out on PNAS: Congratulations to all authors!.
Another preprint out from our lab! MATR3 abundance and RNA binding are regulated by neuronal activity, and pathological mutations disrupt activity mediated degradation of MATR3 via calpain1. This links activity dependent regulation of MATR3 and disease! .
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RT @EliseMarsan: Just OUT: A fantastic commentary on our paper by @EmilePinarbasi & @BarmadaLab! @jclinicalinvest .
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We have an opening for a postdoc! Come work with us on ALS/FTD ⬇️.
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Our story on m6A and TDP43 is now out in Molecular Cell!
Excited to share that our latest preprint is out! Here we show that m6A modulates TDP43 RNA binding and that RNAs are hypermethylated in ALS. We also found if you knockdown an m6A reader, YTHDF2, you can mitigate disease related toxicity!.
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Also, Sami will be giving a talk on MTMR5 and neuronal autophagy at 4:53pm in the "Mechanisms of Autophagic and Endolysosomal Trafficking in Neuronal Function and Neurodegeneration" subgroup tomorrow! #CellBio2022.
Check out our lab's posters at #CellBio2022 tomorrow (Monday Dec 5)!. - Genesis Rodriguez on VPS13A function in mitochondria/ER (P2106/B430).- Josephine Wu on calcium and calmodulin-dependent Matrin3 homeostasis (P2076/B399).- Sumin Kim on neuronal NPC biogenesis (P2019/B339).
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Check out our lab's posters at #CellBio2022 tomorrow (Monday Dec 5)!. - Genesis Rodriguez on VPS13A function in mitochondria/ER (P2106/B430).- Josephine Wu on calcium and calmodulin-dependent Matrin3 homeostasis (P2076/B399).- Sumin Kim on neuronal NPC biogenesis (P2019/B339).
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RT @UMichiganNews: 6 @UMich scientists & engineers have been named the 2022 winners of the #MBioFAR Award, which recognizes exceptional mid….
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RT @UMLifeSciences: Congratulations to @AlisonNarayanUM, who has been named a 2022 MBioFAR awardee! .This #UMBiosciences award recognizes e….
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Congrats @SEWrightPhD!.
Our newest paper is out! @SEWrightPhD and friends discovered that RAN translation of CGG repeats triggers translational frameshifts that create toxic aggregation-prone chimeric proteins! A quick 🧵1/5: #FragileX #ALS #dementia
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Excited to share that our latest preprint is out! Here we show that m6A modulates TDP43 RNA binding and that RNAs are hypermethylated in ALS. We also found if you knockdown an m6A reader, YTHDF2, you can mitigate disease related toxicity!.
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Congratulations to Mike on a fantastic thesis defense today! Mike’s work on m6A and TDP43 opened up many new avenues for the lab to pursue, and he has been pivotal in introducing the lab to science memes. Great job and many congratulations, Dr. McMillan!
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RT @umichrna: Nico Gomez from the @BarmadaLab is primarily interested in exploring how the regulation of nucleic acid, the primary bearer o….
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RT @MadayLab: Honored to highlight exciting work from @BarmadaLab elucidating mechanisms that regulate autophagy in neurons! .
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This work was led by Jason, who recently started his own lab at Johns Hopkins. Check out his review on autophagy and ALS ( and other works on his profile: .
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Our most recent paper is out! We used iNeurons to identify MTMR5 as a regulator of neuronal autophagy. Our findings suggest a potential strategy to modulate autophagy in neurodegenerative disease.
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RT @may_khanna: Excited that this paper is out! . Grp78/BiP/ HspA5 binds directly to TDP‑43 and mitigates toxicity associated with disease….
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RT @biorxivpreprint: Neuronal activity regulates Matrin 3 levels and function in a calcium-dependent manner through calpain cleavage and ca….
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Another preprint out from our lab! MATR3 abundance and RNA binding are regulated by neuronal activity, and pathological mutations disrupt activity mediated degradation of MATR3 via calpain1. This links activity dependent regulation of MATR3 and disease! .
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