aydanszeto
@aydanszeto
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Immunologist @MRC_LMB | Views are my own | he/him 🏳️🌈| I work towards manipulating the Yin and Yang of inflammation #Findmeonbluesky 🥏☁️@aydanszeto
Joined March 2012
Thrilled to share our newest study in @ScienceMagazine. We created Boolean mice and CRISPR screened the heck outta ILC2s 🧵 1/ . @MRC_LMB @wellcometrust @croucherFDN.
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RT @immunonoah: I'll soon be recruiting a postdoc fellow to join us @ MRC LMB to continue developing our programme to understand neuroimmun….
mrc-lmb.cam.ac.uk
RISING TALENT FELLOWSHIP In 2024 the MRC Laboratory of Molecular Biology (LMB) launched the first round of their three-year fully funded fellowship for
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RT @Qi_Tsinghua: (1/4) Our newest discovery on B-cell memory, just published @ImmunityCP: the development of memory B cells from germinal c….
cell.com
Memory B cells (MBCs) emerging from germinal centers (GCs) are crucial for antibody-based vaccines. Luo, Hou, et al. find that T cell-derived interleukin-9 promotes expression of the transcriptional...
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RT @csparano93: Excited to share our new paper in @JExpMed 🎉 We show that NK cells use autocrine TGF-β1 signalling to establish tissue resi….
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RT @sarah_h_ross: From June '24: The transcription factor Mef2d augments type 2 immune responses during allergic lung inflammation, regulat….
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Did a dendritic cell researcher come up with this name 😂.
The Stanford Immunology Review Program for Applicants (SIRPA) assists individuals applying to the Immunology PhD program. Receive a round of feedback on statements of purpose and participate in a mock interview. Registration open from Oct. 4-31, 2024:
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We highlight future areas of interests, including 1) refined mouse models informed by human data, 2) next generation combinatorial targeting mouse strains to study subsets of subsets, and 3) neuronal regulation of type-2 immunity.
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We discuss dendritic cell heterogeneity, tissue-derived signals, intracellular and nuclear events, and single cell RNA-seq in human type-2 pathologies.
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I am pleased to share our open access review article on the recent (<2 years) discoveries and insights in TH2 cell differentiation and function. With @Ana_CFF and Andrew McKenzie.
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Super important issue in the mouse research community to address. Carefully consider and reject all alternative hypotheses, and don’t just assume!.
Passenger mutations in KO mice can influence gene expression & impact experimental results.3 studies this month highlight this issue.- Nlrp3 (inflammasome). - Ackr1 & Ackr2 (chemokine).Check your KO mice.
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Fascinating study on the potentially beneficial role of IL-4 signalling on CAR-T products to persist post-transfusion. Wouldn’t have thought type-2 immunity helps with anti-tumour response, but human immunology is so different and full of surprises 😌.
nature.com
Nature - Elevated type 2 functionality in CAR T cell infusion products is significantly associated with maintenance of a median B cell aplasia duration of 8.4 years in paediatric patients...
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RT @immunonoah: If you're an American passionate about science & thinking to cross the pond to do your PhD consider applying to the @MRC_LM….
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Amazing opportunity to build cutting edge instruments with talented people at @MRC_LMB, Cambridge UK. Help us make microscopy as high-throughput as flow cytometry, whilst retaining resolution 😎.
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When reviewer 2 asks for a single cell RNA-seq just because we could, but adds nothing to the paper
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Direct effect of Abx on mammalian cells 😱.
🚨🚨I’m excited to present our lab’s new paper where we tried to provide a mechanistic explanation for the link between antibiotic use and risk of developing inflammatory bowel diseases (#IBD). A 🧵/1.
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RT @theILCguy: I'm elated to share that my postdoc work is now online @Nature!. If you are interested in neuroimmun….
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Congratulations on adding yet another piece of the puzzle on how dermal type-2 immunity is initiated! The skin is truly a unique barrier site full of goddamn (GD) surprises.
In our new paper out today we started with a simple hypothesis - inspired by work on IL-4/IL-13 from @itchdoctor - that an innate immune cell might control sensory neuronal detection of allergens via a secreted factor. (1/11)
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RT @IrlaLab: Thrilled to announce that our latest research at @CIML_Immunology showing that lymphotoxin acts as an inhibitory checkpoint of….
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One of my pet peeves 🙂↕️ T-2 immunity can be anti-T1/anti-T17 in some contexts but my nasal mucosa during spring time is far from being “anti-inflamed”.
I'm reading SUCH a cool paper, but I just can't!!! NOOOOOOOO Th2 is NOT anti-inflammatory! Th2 is NOT anti-inflammatory! Please help me shout this from the rooftops. Th2/allergic-type responses are highly "inflammatory", just with different disease manifestations than Th1.
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