🎉🎉🎉 Very happy to see my review out in @AnnualReviews on thymic T cell selection ! If you like T cells check it out !🎉🎉🎉

Having a great time with the team ! #immunology #CIML

@IrlaLab and collaborators reveals that RANKL therapy reverses age-related thymic decline, recovering immune health in older adults by restoring youthful T-cell responses to vaccines and tumors. Check their study in @ScienceTM.

New work connects #immunosenescence and the decline of the #thymus during aging with a drop in the ligand #RANKL—and shows RANKL treatment restores T cell production and rejuvenates immune responses in aged mice. @IrlaLab @JrmyCSantamaria @CIML_Immunology https://t.co/UvgV1IzT7z

We provide the proof-of-concept that RANKL stimulates human endothelial and epithelial cells using thymic organo-cultures, providing an exciting new therapeutic approach in the arsenal of regenerative medicine to rejuvenate the immune system.

This increased production leads to peripheral T-cell renewal and improves T-cell-mediated anti-tumor and vaccine responses in aged mice.

RANKL treatment in aged mice restores thymic architecture as well as cellularity and functional properties of endothelial and epithelial cells. This boosted T-cell production in the aged thymus.

We demonstrate that the RANK-RANKL axis in the thymus is altered during aging. In addition to thymic epithelial cells, endothelial cells depend on RANK signaling for their cellularity and functional maturation.

Thanks to @AgenceRecherche (ANRRANKLThym), #FondationBMS, @FondationARC for supporting our project! @IrlaLab , @JrmyCSantamaria , @ArnauldSerg2

Thrilled to share our latest research in @ScienceTM ! We show that RANKL administration reverses age-dependent thymic involution and rejuvenates T cell immunity. @CIML_Immunology #aging #thymus #Tcells #Immunology #Involution #Rejuvenation

One of the alluring and theoretical strategies for extending healthspan and longevity is to rejuvenate the thymus gland, promote an intact immune system. Now there's a way to do that in aged mice. https://t.co/1XVibjLhMK @ScienceTM

I remember being blown away when @IrlaLab showed me these data @CIML_Immunology 🤯 - Exogenous RANKL substantially reverts thymic involution and improves T cell function in aged mice @ScienceTM https://t.co/MhibGjJISP

A new study on @ScienceTM finds RANKL treatment can restore thymic function in aged mice and improve their T cell-mediated immune responses. #aging @JrmyCSantamaria, Dr.Magali Irla @IrlaLab, Antoine Toubert of @univ_paris_cite, et al. https://t.co/TGOHBjTGQi

Congrats to @AlexiaBorelli for successfully defending her PhD thesis at @CIML_Immunology ! Her work has advanced our understanding of Foxp3+ Treg development and thymic recirculation, with 2 first-author papers in @NatureComms and Cell Mol Life Sci. #Treg #Thymus #Immuno #CIML

Vitamin D Deficiency in Childhood Linked to Higher Autoimmune Risk A recent study has found that vitamin D deficiency during childhood accelerates the aging of the thymus, an organ essential for developing a healthy immune system. The thymus helps train immune cells to

Sex-biased human thymic architecture guides T cell development through spatially defined niches: Developmental Cell

Review by Pala et al. highlights how novel cutting-edge technologies, incl. high-resolution imaging, single-cell omics & organoid cultures, have improved our understanding of human #thymus biology https://t.co/IbeijwO65y 📘In our #Autoimmunity collection: https://t.co/a3S5EBTqIX

New issue online! This beautiful cover depicts work from @maxim_artyomov, Pavla Bohacova, Marina Terekhova &co identifying CD38 expression as a marker of recent thymic emigrants. Image credit: Fishy Frog https://t.co/NUVythuEcf

LAI will host a seminar on Wednesday 16th of October at 11 a.m. in the Amphi 12, Bat B - Cyril Favard (IRIM) "Mechanics and Kinetics of HIV-1 assembly in living T cells: insights from single/few molecule dynamics"

Thrilled to announce that our latest research at @CIML_Immunology showing that lymphotoxin acts as an inhibitory checkpoint of thymic Treg development is out in @NatureComms Link: https://t.co/OczapJMvbn @Irlalab @AlexiaBorelli @RafaJArguello #Treg #Thymus #Tcells #Immunology

Lymphotoxin is first inhibitory checkpoint of thymic Treg development that fine-tunes the Foxp3lo Treg precursor pathway by limiting IL-4 availability @IrlaLab @AlexiaBorelli https://t.co/FCbWScDQZX