Check our paper on reversibility of stem cell decisions via posttranscriptional regulation https://t.co/9fBTdiAcNo

📢 We’re live at the @embojournal! 🌐 https://t.co/P5Jy0WiLJn Human telencephalic organoids cultured in the absence of Matrigel endogenously produce and self-organize the extracellular matrix, without affecting programs of neuronal differentiation. Led by @catarinacsmc 👩‍🔬 🧵 1/5

We're so excited to share our latest work “Identification of astrocyte-driven pseudolineages reveals clinical stratification and therapeutic targets in #Glioblastoma” spearheaded by @OghuzhanKaya on the wet & @LCForst on the dry lab as a preprint @Biorxiv https://t.co/r4od0M6d5D

Pioneering method for stem cell diagnostics: Leif S. Ludwig receives Paul Ehrlich and Ludwig Darmstaedter Early Career Award

In total, this provides a new model for how big animals avoid cancer - maybe they’re just better at DNA repair than us? As a next step, I’d love to see this validated in an animal model - if you drive high expression of whale CIRBP in the mouse, are they cancer-resistant?

Excited to share our new work on direct protein-based genome editing in primary cells. We termed it Peptide-Assisted Genome Editing (PAGE) CRISPR-Cas platform. This platform allows rapid and effective editing of primary cells with minimal toxicity.

The reality of doing science is that most of the time you’re really just waiting for something unexpected to happen; something that doesn’t make sense or a wild new idea. When that happens, it’s up to you to change course and go for it, or let the hard-earned opportunity pass by.

Those of us who have survived in academia long enough have an obligation to make things better for the next generation. One concrete way to do that is to support grad students and postdocs in thinking independently and encouraging them to search for new scientific questions.

I have gathered up a bunch of published #SingleCell datasets from @molneurolab and made this thing: https://t.co/XiJoYEPItY Nearly 27000 subventricular zone cells from three different publications available for exploration!

A huge thanks to everyone who made this study possible: my mentor Irv Weissman, the lab's brain team (Rahul @TranscriptomeHQ, Nobuko, Joy, Anna et al.), as well as @czbiohub and @StanfordMSTP for their support!

Here it is: our #inception paper @Dev_journal „De novo PAM generation to reach initially inaccessible target sites for base editing“ by @kaisa_pakari & @_ThomThum_ We use 2 guides & 2 editors to edit distant nucleotides with NGG base-editors https://t.co/E4Qm7dCpRu #medaka #DNA

Drei ERC Synergy Grants für Wissenschaftler der Universität Heidelberg – Europäischer Forschungsrat vergibt hochdotierte Förderungen für komplexe Vorhaben in der Forschung https://t.co/r3GKbwO98z

It's time we ban assault weapons so our kids learn to read and write in schools instead of learning to duck and cover.

Congrats to the Vorholt @Microbio_ETH and @BartDeplancke for their landmark paper on Live-seq, a method for recording the transcriptome from single cells without killing them! ETH news article: https://t.co/45DWanTC6I Paper: https://t.co/noxjOYw4zw

We're excited to share our latest preprint where we use #singlecell #multiomics to show that stemness is encoded in the methylome of neural #stemcells (NSC) in the adult #brain 🐁🧠 #epigenetics #neuroscience #biorxiv_neursci 👉 https://t.co/2DDNfRQjas 🧵1/9

After a couple of great years at @uni_mainz_eng, I recently returned to @DKFZ to team up again with Prof. Dr. Frank Lyko and the fantastic scientists of my beloved @dkfzEpigenetics. I am really very happy to be back! See you in Heidelberg from now on for more & better science🧬!

Submitted my abstract for the #CSHLglia meeting 2022 to represent @molneurolab @CSHL! So excited to meet the community and share/discuss the results of my PhD project 👨🏽‍🔬

A timely meeting ⏰ #EMBODevTempo https://t.co/9fLSCnFc6u

Happy to share our recent paper published in Science Advances @ScienceAdvances The mechanisms of astrocyte increase during evolution, and its role in cortical folding. Localized astrogenesis regulates gyrification of the cerebral cortex

Registration for the 24th Biennial Meeting of the International Society for Developmental Neuroscience is open! Submit abstracts by April 9 ,2022 #DevelopmentalNeuroscience @ISDNConference