Oğuzhan Kaya
@OghuzhanKaya
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#MSCA Postdoctoral Fellow @Knoblich_Lab @IMBA_Vienna He/him 🏳️🌈
Heidelberg, Deutschland
Joined November 2018
I'm incredibly excited and proud to finally share the main results of my #PhD where together w/ @lcforst and @amartinvill we attempted to reveal organizational princples of #Glioblastoma through the lens of adult neural #StemCell biology @molneurolab @DKFZ #PrePrint #Tweetorial🧵
We're so excited to share our latest work “Identification of astrocyte-driven pseudolineages reveals clinical stratification and therapeutic targets in #Glioblastoma” spearheaded by @OghuzhanKaya on the wet & @LCForst on the dry lab as a preprint @Biorxiv
https://t.co/r4od0M6d5D
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Brain tumors consist of cells in successive stages of activation. Researchers at DKFZ and Heidelberg University have discovered a signaling protein that could keep the cancer cells in a dormant state - with the hope of halting tumor growth. #Glioblastoma
https://t.co/F5oUKvwsEC
dkfz.de
Every brain tumor is made up of cells in successive stages of activation. Researchers at the German Cancer Research Center (DKFZ) and Heidelberg University have now analyzed the individual structure...
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Hirntumoren bestehen aus Zellen in verschiedenen Aktivierungsstadien. Forschende von DKFZ und Universität Heidelberg entdeckten ein Signalprotein, das die Krebszellen im Ruhezustand halten könnte - mit der Hoffnung, das Tumorwachstum aufzuhalten. https://t.co/15ojrw6PyC
dkfz.de
Jeder Hirntumor ist aus Zellen in aufeinander abfolgenden Aktivierungsstadien aufgebaut. Forschende vom Deutschen Krebsforschungszentrum (DKFZ) und der Universität Heidelberg haben nun bei bösartigen...
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Macrophage-mediated myelin recycling fuels brain cancer malignancy: Cell
cell.com
Recycling of cholesterol-rich myelin debris by macrophages leads to the emergence of lipid-laden macrophages (LLMs) in glioblastoma. LLMs support glioblastoma malignancy through transfer of myelin-...
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🎉 Excited to share our latest study in @nature, showing that DNA🧬 #methylation is key to stemness in the adult #brain: https://t.co/UkZDm4NbdN A collaboration with @s_anders_m, driven by @LPMKremer and @SCerrizuela. #epigenetics #neuroscience #singlecell. Pre-print summary 🧵👇
We're excited to share our latest preprint where we use #singlecell #multiomics to show that stemness is encoded in the methylome of neural #stemcells (NSC) in the adult #brain 🐁🧠 #epigenetics #neuroscience #biorxiv_neursci 👉 https://t.co/2DDNfRQjas 🧵1/9
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.@LPMKremer, @molneurolab, @s_anders_m and colleagues introduce a data processing approach along with an easy-to-use software tool MethSCAn for scBS-seq data analysis. https://t.co/WUcW1EBtDo
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Our laboratory for blastoid development and implantation is seeking a postdoctoral fellow to work with us on human embryogenesis. Our core-funded laboratory is located at the IMBA Institute of the Austrian Academy of Sciences in amazing Vienna. Please reTweet and get in touch!
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Well now that's a lab to watch out for, for all the exciting science to come 🔬🧪🧫
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What gets measured gets mastered. Beautiful illustration of the explosion of high resolution functional genomic data over the last several years. Plus the computational methods developed to harness the matrices pouring forth. Artistic credit to @markabelan & @artscistudios
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Congratulations to @molneurolab on their latest @biorxivpreprint. Some great @ResolveBioSci #singlecell #spatialtranscriptomics data too...
We're so excited to share our latest work “Identification of astrocyte-driven pseudolineages reveals clinical stratification and therapeutic targets in #Glioblastoma” spearheaded by @OghuzhanKaya on the wet & @LCForst on the dry lab as a preprint @Biorxiv
https://t.co/r4od0M6d5D
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Special thanks to my wondeful MSc students Noelia, Kevin, @MilicaBekavac, Nina and @vuslatakcay as well as our funding agencies @ERC_Research @sfb1324 and collaborators @DKFZ @UniHeidelberg @UniklinikUlm @TheNeuro_MNI
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We hope that our pseudolineage-centric framework offers a fresh perspective on tumor organization in the adult brain, revealing overarching princples underlying stem cell activation that might be expoited across different tumor entities.
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Excitingly, targeting the transition from quiescence to activation by secreted Wnt antagonists SFRP1 or Notum in #HumanBrainOrganiods & mice drove cells toward an astrocytic stage reflected at tumor's methylome, (spatial) transcriptome & histology, ultimately enchancing survival.
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Leveraging the insights offered by #ptalign, we identified global dysregulations in the #WntSignaling pathway at critical stage transitions across tumors, paving the way to discover actionable targets to break down malignant hierarchies.
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Inspired by the methylome #reprogramming of injury induced neurogenic activation of astrocytes (by @SCerrizuela & @LPMKremer; https://t.co/1SVsFwF46F), we identified methylation- and expression-based biomarkers of pseudolineages for #PatientStratification and disease monitoring.
biorxiv.org
Stem cells in the adult brain are specialized astrocytes capable of generating neurons and glial cells. While neural stem cells (NSCs) and common astrocytes have clearly distinct functions, they...
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Analyzing data from >400 patients, we uncovered a surival advantage for complete pseudolineages enriched for quiescence over truncated ones that are rendered active.
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Challenging established principles, we demonstrated that glioblastoma cells, much like their healthy counterparts, span across a quiescence-activation-differentiation axis.
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We first developed #ptalign to project single tumor cells (by miniaturized #SS3 @sandberglab) onto healthy trajectories derived form the same tissue to contextualize malignant lineage transitions in the adult brain, introducing the concept of tumor #pseudolineages
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Are specific cell types or processes during brain development more vulnerable in autism? We explore this using a single-cell functional genomics approach in brain organoids. Excited to share our latest findings, and thanks for this wonderful collaboration @josch_f @TreutleinLab!
We are thrilled to share our latest work, a collaborative effort with @TreutleinLab, in Nature ( https://t.co/pChgPCFEOM). We introduce CHOOSE, a powerful screening system within cerebral organoids, through which we identified developmental defects associated with autism. 🧵1/7
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Ben Barres Spotlight Awards: Applications open for 2023
elifesciences.org
Researchers from underrepresented backgrounds or from countries with limited funding can now apply for an award of up to $5,000 to support their research, career and community.
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