Jason Sheltzer
@JSheltzer
Followers
18K
Following
6K
Media
960
Statuses
5K
Assistant prof at @StanfordMed. Interested in aneuploidy, mitotic kinases, cancer therapeutics, and drug development. Co-founder x2.
Joined February 2016
Check out our new study in @ScienceMagazine, where we take on a 100-year-old debate: what’s the role of aneuploidy in cancer? We discovered that genetically removing extra chromosomes blocks cancer growth - a phenomenon we call “aneuploidy addiction”.
science.org
Specific aneuploidies benefit cancer cells and may be sensitive to treatment
47
342
1K
Many academic disciplines have famous geographic divisions- In economics, freshwater (midwestern, free-market) vs. saltwater (coastal, Keynesian) In philosophy, continental (European, Kantian) vs. analytical (British, logical) Do any geographic divisions exist in biomedicine?
3
0
9
Got stuff you’re ready to resell? SHEINexchange keeps fashion in closets longer with peer-to-peer reselling. Together, we’re helping to make sure more clothes continue to be loved and used—one outfit at a time. Hit the link to learn more.
10
84
243
Me on Twitter: "AI for science is over-hyped, you all need to stop being so excitable and grow some agency. AI isn't going to cure cancer, you have to cure cancer" Me when as soon as I switch tabs:
12
15
227
This project will build on our recent publication in which we studied the consequences of invdupdel(8p) in a novel isogenic setting and characterized its effects on gene expression and neural differentiation: https://t.co/o46UzpvQzx.
pubmed.ncbi.nlm.nih.gov
Chromosomal rearrangements on the short arm of Chromosome 8 cause 8p syndrome, a rare developmental disorder characterized by neurodevelopmental delays, epilepsy, and cardiac abnormalities. While...
0
0
4
I’m excited to share a new postdoctoral opportunity in my lab to use chromosome engineering to study the consequences of chromosomal rearrangements in iPS cells. Check out the posting below and shoot me an email if you’re interested -
4
65
211
Story: https://t.co/7pptwdsrpf Good thing there wasn't a market for the Medicine Prize this year, or I'd be donating plasma for lunch money now 🙃🙃
bloomberg.com
Norwegian officials in charge of awarding the Nobel Peace Prize are investigating information that online bets on this year’s recipient surged overnight, suggesting a potential leak of information.
0
0
4
In other Nobel-related news - some insiders placed large bets on the eventual winner on Polymarket before the Peace Prize was announced and collected a nice profit. Norwegian officials are investigating...
2
4
6
Dr. Yaghi did his Nobel-winning work in the US, at the University of Michigan, UCLA, and UC Berkeley. Being welcoming to immigrants helps make American science the best in the world.
This year’s chemistry laureate Omar Yaghi was born in Amman, Jordan, in 1965 to parents who were refugees from Palestine. When we spoke to him he shared his story: “I grew up in a very humble home, we were a dozen of us in one room, sharing it with the cattle that we used to
15
105
685
The stock price for $SNOA (Sonoma Pharmaceuticals) shot up 10% after the Nobel Prize announcement this morning - but it's the wrong company. Fred Ramsdell works for Sonoma Biotherapeutics, which is not publicly listed!
Congratulations to 2025 Nobel Prize winner Fred Ramsdell, PhD, Sonoma Biotherapeutics co-founder, former Chief Scientific Officer, and current Chair of the Scientific Advisory Board. Read more here: https://t.co/dfPTrKUo8v
3
11
115
BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
468
12K
29K
Finally - among the American "Nobel finalists", 12 of them are immigrants or the children of immigrants. An important reminder of how immigration helps make American science the best in the world.
2
7
82
The 2020 CRISPR Nobel was very much dedicated to the basic discovery and characterization of CRISPR systems. If base/prime editing continues to be useful for treating genetic diseases, in 10-15 years I could see a second CRISPR prize to Liu for CRISPR-based medicine.
1
1
12
Plus, my long-term “dark horse” prediction: David Liu has jumped onto the candidates’ list by winning the 2025 Breakthrough Prize for CRISPR gene editing without causing DNA breaks. There have also been some phenomenal stories of CRISPR therapies based on his lab’s work.
1
0
26
Strong candidates also include Deisseroth for optogenetics and Jeff Friedman for leptin signaling/obesity.
1
2
13
In my view, the most likely 2025 Nobel winners are Klenerman/Balasubramanian for the development of next-gen sequencing, Mary-Claire King for hereditary breast cancers, and Hartl/Horwich for protein folding.
1
5
42
Recently, a number of new discoveries have jumped up the likely list, including therapies for cystic fibrosis (2025 Lasker, 2025 Gairdner, and 2024 Breakthrough), GLP1 analogs (2024 Lasker and 2025 Breakthrough), and characterizing Notch (2025 Wiley and 2025 Gairdner).
1
0
9
The 2024 Medicine winners (Ambros/Ruvkun) had previously won the Lasker, Gairdner, Horwitz, Wolf, and Breakthrough Prizes. The Chem winners (Hassabis/Jumper/Baker) won the Breakthrough and Wiley Prizes, while Hassabis+Jumper also won the Gairdner and Lasker.
1
0
11
The Nobel is rarely the first prize that a scientist wins - typically it’s the last, given after a long career, with prior recognition by many other award committees.
1
0
11
In two weeks, the 2025 Nobel Prizes will be announced. Based on looking at other pre-Nobel “predictor” prizes, I think that these 36 scientists are the most likely candidates:
23
44
439
Unscrewing caps, trypsinizing cells, taking off lids, pressing "start" and "stop" buttons - bench science is full of tasks that are incredibly hard to automate. It's great to see a company tackling this challenge and I think that it'll have an exponential impact on drug dev.
AI is not on track to eradicate disease in our lifetime. Scientists need to generate more data, but they’re physically limited by how fast they can work. That’s why we’re launching Medra: Physical AI in the lab, doing and optimizing real experiments. Thread👇
1
4
21
Hypothesis: maybe there's a hypomorphic allele in an essential gene on Chr18 or 19, and trisomies of those chromosomes are selected to raise the dosage of those proteins to wild-type levels? Link to the paper:
onlinelibrary.wiley.com
Mosaic variegated aneuploidy (MVA) is an autosomal recessive disorder characterized by mosaic aneuploidies, predominantly trisomies, involving multiple different chromosomes and tissues. The propor...
1
0
3