Check out our new study in @ScienceMagazine, where we take on a 100-year-old debate: what’s the role of aneuploidy in cancer? We discovered that genetically removing extra chromosomes blocks cancer growth - a phenomenon we call “aneuploidy addiction”.

Many academic disciplines have famous geographic divisions- In economics, freshwater (midwestern, free-market) vs. saltwater (coastal, Keynesian) In philosophy, continental (European, Kantian) vs. analytical (British, logical) Do any geographic divisions exist in biomedicine?

Grove integrates with @aave's RWA market, Horizon. Grove is supplying @ripple’s RLUSD and @circle’s @USDC to deepen liquidity for qualified borrowers using tokenized RWAs as collateral. Pending governance approval. Another important step toward our mission of bridging DeFi and

Me on Twitter: "AI for science is over-hyped, you all need to stop being so excitable and grow some agency. AI isn't going to cure cancer, you have to cure cancer" Me when as soon as I switch tabs:

This project will build on our recent publication in which we studied the consequences of invdupdel(8p) in a novel isogenic setting and characterized its effects on gene expression and neural differentiation: https://t.co/o46UzpvQzx.

I’m excited to share a new postdoctoral opportunity in my lab to use chromosome engineering to study the consequences of chromosomal rearrangements in iPS cells. Check out the posting below and shoot me an email if you’re interested -

Story: https://t.co/7pptwdsrpf Good thing there wasn't a market for the Medicine Prize this year, or I'd be donating plasma for lunch money now 🙃🙃

In other Nobel-related news - some insiders placed large bets on the eventual winner on Polymarket before the Peace Prize was announced and collected a nice profit. Norwegian officials are investigating...

$SKYX- Bob Nardelli, former CEO of Home Depot, described SKYX’s plug-and-play lighting as “AMAZING TECHNOLOGY everyone should take a hard look.

Dr. Yaghi did his Nobel-winning work in the US, at the University of Michigan, UCLA, and UC Berkeley. Being welcoming to immigrants helps make American science the best in the world.

The stock price for $SNOA (Sonoma Pharmaceuticals) shot up 10% after the Nobel Prize announcement this morning - but it's the wrong company. Fred Ramsdell works for Sonoma Biotherapeutics, which is not publicly listed!

BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

Finally - among the American "Nobel finalists", 12 of them are immigrants or the children of immigrants. An important reminder of how immigration helps make American science the best in the world.

The 2020 CRISPR Nobel was very much dedicated to the basic discovery and characterization of CRISPR systems. If base/prime editing continues to be useful for treating genetic diseases, in 10-15 years I could see a second CRISPR prize to Liu for CRISPR-based medicine.

Plus, my long-term “dark horse” prediction: David Liu has jumped onto the candidates’ list by winning the 2025 Breakthrough Prize for CRISPR gene editing without causing DNA breaks. There have also been some phenomenal stories of CRISPR therapies based on his lab’s work.

Strong candidates also include Deisseroth for optogenetics and Jeff Friedman for leptin signaling/obesity.

In my view, the most likely 2025 Nobel winners are Klenerman/Balasubramanian for the development of next-gen sequencing, Mary-Claire King for hereditary breast cancers, and Hartl/Horwich for protein folding.

Recently, a number of new discoveries have jumped up the likely list, including therapies for cystic fibrosis (2025 Lasker, 2025 Gairdner, and 2024 Breakthrough), GLP1 analogs (2024 Lasker and 2025 Breakthrough), and characterizing Notch (2025 Wiley and 2025 Gairdner).

The 2024 Medicine winners (Ambros/Ruvkun) had previously won the Lasker, Gairdner, Horwitz, Wolf, and Breakthrough Prizes. The Chem winners (Hassabis/Jumper/Baker) won the Breakthrough and Wiley Prizes, while Hassabis+Jumper also won the Gairdner and Lasker.

The Nobel is rarely the first prize that a scientist wins - typically it’s the last, given after a long career, with prior recognition by many other award committees.

In two weeks, the 2025 Nobel Prizes will be announced. Based on looking at other pre-Nobel “predictor” prizes, I think that these 36 scientists are the most likely candidates:

Unscrewing caps, trypsinizing cells, taking off lids, pressing "start" and "stop" buttons - bench science is full of tasks that are incredibly hard to automate. It's great to see a company tackling this challenge and I think that it'll have an exponential impact on drug dev.

Hypothesis: maybe there's a hypomorphic allele in an essential gene on Chr18 or 19, and trisomies of those chromosomes are selected to raise the dosage of those proteins to wild-type levels? Link to the paper: