Microbiology_ETH
@Microbio_ETH
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A great place to do science!
Zürich, Switzerland
Joined July 2012
Jörn Piel honoured with prestigious European medical award! More at Bluesky
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Julia Vorholt wins the 2025 Novonesis Biotechnology Prize for her groundbreaking research on plant microbiomes! More on Bluesky:
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A study by the Hardt lab, with the Sauer and von Mering labs, shows that sugars are abundant in the gut and drive Salmonella Typhimurium expansion across murine models.
nature.com
Nature Communications - Here, Schubert et al. investigate the metabolic requirements for Salmonella Typhimurium colonization using a barcoded mutant pool across five different mouse models with...
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A recent study by the Hardt lab at ETH Zurich in collaboration with the von Mering and Vorholt lab demonstrates that host neutrophils predispose Salmonella Typhimurium elimination by commensal E. coli. 👉 https://t.co/fw5fVjlMxQ
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Mechanistic Insights Into Post-Translational α-Keto-β-Amino Acid Formation by a Radical S-Adenosyl Methionine Peptide Splicease (Anna L. Vagstad, Jörn Piel and co-workers) @Microbio_ETH @piel_lab •
onlinelibrary.wiley.com
Noncanonical protein splicing illuminated: Radical S-adenosyl methionine spliceases post-translationally install α-keto-β-amide residues in a widespread family of peptide natural products. Here, we...
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What is the story behind Anna Vagstad's favorite molecule, jawsamycin? @Microbio_ETH, @piel_lab Find out on her #IntroducingAngewandte page https://t.co/ckyfDhggBF • https://t.co/Hx8D0zPRCD
Mechanistic Insights Into Post-Translational α-Keto-β-Amino Acid Formation by a Radical S-Adenosyl Methionine Peptide Splicease (Anna L. Vagstad, Jörn Piel and co-workers) @Microbio_ETH @piel_lab •
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Noncanonical protein splicing illuminated. A recent study by the Vagstad and Piel groups at ETH Zurich in collaboration with the Rieher, @BroderickLabFeS, @theStockerLab , and Gugger labs sheds light on the installation of protease-inhibiting ketoamides.
onlinelibrary.wiley.com
Noncanonical protein splicing illuminated: Radical S-adenosyl methionine spliceases post-translationally install α-keto-β-amide residues in a widespread family of peptide natural products. Here, we...
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Thrilled to finally share! The plant microbiota triggers dose-dependent immune responses that feed back to influence bacterial colonization. This affects non-pathogenic and pathogenic strains, impacting microbiota homeostasis. Out today in @NaturePlants:
nature.com
Nature Plants - The plant general non-self response system is triggered by leaf microbiota members and, in turn, impacts their colonization.
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Post-translational modifications confer important functions on peptides and proteins. The Piel lab @ETH_en Zurich and collaborators discovered a new modification resulting in complex, steroid-like amino acids. More: https://t.co/1pw7FKo7gi
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Metabolic plasticity of STm Hardt lab @Microbio_ETH reveals metabolic adaptations of #Salmonella Typhimurium to changes during infection, i.e. diversification of mixed-acid fermentation & use of partial TCA cycle in response to redox & nutritional changes https://t.co/2aznyLSt6t
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Successful induction of artificial #endosymbiosis by @GabrielGiger and the #VorholtLab @Microbio_ETH using #FluidFM allows to study critical early events and to design endosymbioses with desired traits. @ETH @ETH_DBIOL @LeibnizHKI #Evolution
@Nature:
nature.com
Nature - A study presents an approach to establish and track a new endosymbiotic partnership by implanting bacteria in a non-host fungus and shows that stable inheritance of the implanted bacteria...
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Bacteria inside fungi! A new study by the #VorholtLab shows how artificial endosymbiosis can transfer a metabolic function and drive innovation in biology. @Nature: https://t.co/ZGiyuaQuVJ
@ETH_en:
ethz.ch
An organism as a tenant in another - in biology, this often works quite well. ETH researchers have now shed light on how such a partnership of a cell in a cell can establish.
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Metabolic plasticity of STm Hardt lab @Microbio_ETH reveals metabolic adaptations of #Salmonella Typhimurium to changes during infection, i.e. diversification of mixed-acid fermentation & use of partial TCA cycle in response to redox & nutritional changes https://t.co/2aznyLSt6t
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The recent Wolfsberg Meeting of the Swiss PhD students in immunology was again a big success! 70 PhD students in immunology and 7 professors from different Swiss Universities made it an inspiring meeting of high scientific quality 👉 https://t.co/UAugyxZBUX
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🦠📷 OUT NOW! Non-canonical start codons in carbohydrate utilisation operons provide context-dependent advantages for commensal E. coli by Yassine Cherrak, Wolf-Dietrich Hardt and colleagues https://t.co/ybMkBvv2eW
nature.com
Nature Microbiology - Non-canonical start codons promote carbohydrate exploitation and faster metabolic adaptation, conferring growth advantages to commensal Escherichia coli in the mouse gut.
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Thrilled to share our work on commensal-mediated Samonella competition in the inflammed gut! Very grateful for the help of my brillant colleagues at the Hardt group @ETH_DBIOL and the support we got from the @snsf_ch, @NCCRMicrobiomes & @EMBO
https://t.co/pih7zU8BQf
journals.plos.org
The microbiota serves as the first line of defence against pathogen invasion in the gut. This study shows that, in a mouse model of salmonellosis, commensal E. coli 8178 uses a trojan horse strategy...
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Are you a school class curious about our biology research and teaching at ETH? Come visit us! Recently, students from Stiftsschule Einsiedeln got an inside look at cutting-edge cancer research, our biology program and the Hönggerberg campus. #FutureScientists #ScienceEducation
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The Vorholt & Hardt labs @Microbio_ETH & @SellinLab use FluidFM to study Salmonella in intestinal epithelial cells. Find out what happens if you inject bacteria directly into the cells’ cytosol. D-BIOL news: https://t.co/vnNET0KnN4 To the paper:
journals.plos.org
A previous study in PLOS Biology developed a FluidFM-based approach to inject organelles into living cells. Using this technology, this study shows that establishment of a Salmonella Typhimurium...
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Huge congratulations to Julia Vorholt on her election to the National Academy of Sciences @theNASciences !! https://t.co/Q1qKLHAgfR
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#PLOSBiology: #VorholtLab uses #FluidFM to inject Salmonella into enteroid cells, disentangling pathogen-host cell interactions in the cytosol, uncoupled from earlier infection stages. Explore these groundbreaking findings. @ETH @Microbio_ETH
journals.plos.org
A previous study in PLOS Biology developed a FluidFM-based approach to inject organelles into living cells. Using this technology, this study shows that establishment of a Salmonella Typhimurium...
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