Alvaro Sanchez-Martinez
@alsanchezmar
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Senior Research Associate at @Cambridge_Uni @MRC_MBU with interest in the mechanisms underlying mitochondrial homeostasis in neurological diseases.
Cambridge, England
Joined May 2015
🚨 Calling all researchers in neurodegenerative diseases! 🚨 Submit your manuscript & join EMP in shaping the future of biomedical research. https://t.co/iJf4G74Ioz
@ELSpharma
#NeurodegenerativeDiseases #CallForPapers #BiomedicalResearch #Pharmacology #pathtwitter #Elsevier
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Invitation to researchers specializing in Metabolism!📰 Submit your manuscript now and be part of EMP’s mission to advance biomedical research🤓 https://t.co/XYB6kh8rpT…
@ELSpharma
#Metabolism #CallForPapers #BiomedicalResearch #Pharmacology #pathtwitter #Elsevier
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🚨Attention Molecular Biology Researchers🚨 Submit your manuscript to EMP & contribute to advancing cutting-edge biomedical research! Learn more about our expanded scope here: https://t.co/XYB6kh8Zfr
@ELSpharma
#MolecularBiology #CallForPapers #BiomedicalResearch #Elsevier
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Paper alert. Insights on papers published in our special research topic on #mitochondria and #neurodegenerative_diseases, volume II @FrontNeurosci. Great collaborating with you @alsanchezmar @Federica_DeLazz @gloriabreacalvo Thanks to the reviewers too!
frontiersin.org
The second volume of our editorial is a continuation of the first (Hannan et al., 2022) and features two reviews and three research articles that highlight h...
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We are excited to share our latest work on mechanisms that protect from mitochondrial dysfunction. Thank you to all collaborators and the 4th anonymous reviewer for supporting us. @labs_mann @NatureComms @metaboflo
https://t.co/xLNyW00oil
nature.com
Nature Communications - Finding ways to compensate for mitochondrial dysfunction is essential. Here, the authors performed a genome-wide genetic screen to identify genes that mitigate the larvae...
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New paper out! #AMPK regulates #ULK1 to balance #mitophagy of functional vs dysfunctional mitochondria in @MolecularCell. Great work from authors, especially Marianna Longo @AnikethBishnu and collaborators @Kei_Sakamoto @CarolMacKintos1. See it here: https://t.co/BVDu2ilrQ9
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Does a transmembrane sodium gradient control membrane potential in mam...
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New study from us: https://t.co/GioeqFmsKo High mtDNA copy number promotes lung cancer growth in the mouse, whereas mtDNA depletion in tumor cells reduces tumor growth. This tumor-intrinsic role for mtDNA can be exploited for development of future lung cancer therapies.
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Inspiring science at the Postdoc Networking Day yesterday at @AstraZeneca. Happy to have contributed to this wonderful event with the Cambridge Biomedical Campus and @AstraZeneca. Huge thanks to Jonathan Lawson for organising this gathering. The MBU Postdoc Society
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Please have a look at our recent review on mito-dynamics!
Thrilled to share the last review of the lab led by @Tabara_LC and @MayukoSegawa on the mechanisms regulating mitochondrial morphology!!! @MRC_MBU Just out in @NatRevMCB. Thanks @lisa_heinke for the smooth editorial process!
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A small gift to celebrate the Postdoc Appreciation Week!! 😊 Thank you all for your great work and commitment to science! 🔬 The MBU Postdoc Society @MBU_postdocs @MRC_MBU (thank you @MariangelaDiony for your help 😉)
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⚠️New issue of #mitophagy news 🪫🔋🗑️ Lots of papers, sorted by yours truly with the help of @Bims_BiomedNews
https://t.co/IXxAjDrhp0 See below for highlights in the following categories: 1) Cellular & Molecular mechanisms 2) Pathophysiological relevance 3) Experimental tools
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📣New @biorxivpreprint from @mito911_! @Basak94Bishal & @ErikaHolzbaur present a new stress response pathway regulating #mitophagy in #neurons through degradation of the autophagy negative regulators MTMR5/2 and Rubicon @ASAP_Research @MichaelJFoxOrg
https://t.co/lXo4Jw6Kad
biorxiv.org
Mutations in genes that regulate mitophagy, a key mitochondrial quality control pathway, are causative for neurological disorders including Parkinson’s. Here, we identify a novel stress response...
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Thrilled to announce that our project has been published in @CellCellPress. In this work, we link mitochondrial dynamics to mitochondrial quality control and mtDNA maintenance by characterizing the molecular function of MTFP1. Please DM; happy to discuss!
cell.com
MTFP1 prevents altered inner mitochondrial membrane subdomains from fusing with the healthier mitochondrial network, enabling their isolation and subsequent autophagic degradation. The findings...
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We’re hiring! The Whitworth lab (Mitochondrial Neurodegeneration) is recruiting a postdoc to work on mechanisms of #calcium and #iron handling on #mitophagy in mouse or iNeuron models of neurodegeneration. https://t.co/3Qukb9HE6x
https://t.co/Caw6CKTW4K
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Delighted to share the last study of the lab led by the fantastic postdoc @Tabara_LC out in @CellCellPress !!! We show how MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels. @MRC_MBU @Cambridge_Uni
https://t.co/xM0vjtReOW
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Remember Nucleoid-phagy? @LabPrudent @Tabara_LC
Another one! Such a week! Who would have guessed it!? TFAM as an autophagy receptor to mitigate immune response of leaked nucleoids! https://t.co/Vbc2YGUJRO
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Congrats to our PhD student @lucialugut on the selection of her abstract for presentation at #DMMgenetics in Edinburgh! 🎓 #PhD @MRC_MBU @MRCMitoCluster @MRCMouseNetwork
Thrilled to present some of my PhD results at the #DMMgenetics meeting today in the beautiful Edinburgh 🏰🧬
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Read our new study: https://t.co/o6WNyQI38n Treatment of obese mice with small molecule inhibitors of mtDNA transcription (IMTs) leads to marked beneficial metabolic effects. The weight is normalized, the fat deposition in liver disappears and glucose homeostasis is normalized.
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