⏰ Don’t miss the chance to apply for this postdoc opportunity in spatial & single-cell proteomics in our lab @karolinskainst! Plenty of exciting resources and projects on mitochondria and metabolism. Deadline: May 5 👉 https://t.co/s2OwyTqWMa #mitochondria #metabolism #singlecell

Nano-scale, mega-impact: nanoPhos delivers 100× phosphoproteomics sensitivity, 70k sites from 1µg, 8k from 10ng! Powered by SPEC, it enables phosphoDVP: deep spatial phosphoproteomics from 1000 neurons, hitting 17k sites, a game changer for spatial omics. https://t.co/S9UdwkLh2x

Our paper is out in @Nature today! We use Deep Visual Proteomics (DVP) to dissect α1-antitrypsin deficiency (AATD) in human liver at single-cell resolution. Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time. https://t.co/ZpmXqsn1HC

Keen on a cutting-edge postdoc at the interface of bio and tech? Join us at Karolinska Institutet to unravel metabolic stress with spatial single-cell proteomics. Apply by May 5! https://t.co/C6AKKbS8Rs #proteomics #postdoc #mitochondria #spatialbiology 👉

Have you ever wondered if liver zonation is conserved from mice to humans? And how does fibrosis affect zonation in patients? Now, these questions are answered using scDVP. Some collaborations are meant to be @CarolineWeiss30 @metaboflo @labs_mann @MLSB_Borgwardt

We are excited to share our latest work on mechanisms that protect from mitochondrial dysfunction. Thank you to all collaborators and the 4th anonymous reviewer for supporting us. @labs_mann @NatureComms @metaboflo https://t.co/xLNyW00oil

Preprint alert!! How zonated hepatocytes adapt to changes in lipid influx due to fasting or a Western diet (WD). We developed a microscopy-based phenotyping method called single-cell phenomics (scPhenomics) to measure the features of mitochondria and lipid droplets (LDs).

The wait is over!! We are thrilled to announce that we have chosen Spatial Proteomics as 2024’s Method of the Year! 🥳 For more on Spatial Proteomics and a road map to this special issue, please see this month’s Editorial or read on in this thread. https://t.co/phXooJzJda

Consensus on the key characteristics of metabolism disruptors | Nature Reviews Endocrinology https://t.co/vX5MjPhQJY

Thanks @ScienceCluster for this great conference on metabolism in space and time, and so cool to see the research illustrated by @nigrelex

New study from us: https://t.co/GioeqFmsKo High mtDNA copy number promotes lung cancer growth in the mouse, whereas mtDNA depletion in tumor cells reduces tumor growth. This tumor-intrinsic role for mtDNA can be exploited for development of future lung cancer therapies.

Guess what? Mitochondria are weirder than we thought

AATD affects thousands, causing liver & lung disease via protein aggregation. Our new preprint used #DeepVisualProteomics to study liver cells and reveals key AATD insights with clinical implications . Video and tweetorial @metaboflo #Alpha1Awareness https://t.co/81egcO73Sv

Very honored to have won the ECR poster competition for our work on single cell DVP of alpha-1 antitrypsin deficiency 🥳Special shoutout to @metaboflo for letting me lead the scDVP efforts in this project and for everyone interested, keep your eyes peeled 👀 #Alpha1Awareness

Interferons & STAT1 pathways underlie often fatal skin reaction toxic epidermal necrolysis – JAK inhibitors are potential cures 📷:@NordmannThierry et al @labs_mann @MPI_Biochem in @Nature ➡️: https://t.co/XC3VLFE3rD

Published today! Spatial proteomics reveals JAK/STAT as a target for Toxic Epidermal Necrolysis, an often fatal skin reaction to common medication. We validated our findings in pre-clinical models & successfully treated the first patients worldwide.🧵⬇️

Molecular metabolism is the hottest field in biology and medicine in the next 10 years. Here the importance summarized by six leaders in the field - metabolic heterogeneity in humans. @hchristofk, Josh Rabinowitz et al.

Frontier Grants 3, to start your group at our department @karolinskainst with a startup package 1,1 M€, is now open! https://t.co/XavP6YOcfl Join us and @Katrinardottir @metaboflo @chris_zie, deadline 13 September, please spread the word!

Congratulations, Matthias, for receiving the #HeinekenPrize. What an honour!

My lab @MCF_UoM is #hiring a Research Technician. I'm looking for someone with experience in #iPSC & #microscopy. You will be trained in #proteomics and the project will tackle the mechanisms underlying rare neurological diseases. Apply now! https://t.co/YIAYh70a85 #pleaseshare