Ganley Lab
@LabGanley
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Autophagy and mitophagy in health and disease
Dundee
Joined April 2021
I want to highlight this Workshop I will be chairing with Prof Tiong Ong on Mitochondria Biology at #ESHCML2025 meeting in Estoril. We are lucky to have 3 excellent speakers, Ian Ganley @LabGanley Payam Gammage @mito_oncogene and Els Mansell @ElsyDutchy, sharing their expertise!
📣#ESHCML2025 PROGRAM HIGHLIGHT: WORKSHOP FOR NON-CLINICAL SCIENTISTS #1 Learn more here ➡ https://t.co/Q84gZ5s5Ix ESH-#iCMLf 27th John Goldman Conference on #CMLsm October 10-12, 2025/Estoril, Portugal Chairs: @GCC_Cortes, @timhughesCML, Daniela S. Krause #ESHCONFERENCES @icmlf
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Our latest interview is with 2025 @Official_BSCB l Hooke Medal winner Ian Ganley of the University of Dundee @mrcppu. We spoke with Ian about his career journey, his approach to mentorship and his pet snowflake moray, Eel Armstrong. https://t.co/7gesKysLFn
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Registration for the joint Autophagy UK & Proteostasis UK meeting is now open. Going to be a great meeting and we look forward to welcoming you to Dundee!
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Opposing roles for AMPK in regulating distinct mitophagy pathways. Check out this recent article in @MolecularCell by @LabGanley, Marianna Longo, @AnikethBishnu @Kei_Sakamoto, @CarolMacKintos1 #CellBio2024
cell.com
Under energetic stress, it is essential to balance dysfunctional versus healthy mitochondrial turnover. Longo and Bishnu et al. uncover a mechanism by which AMPK activation achieves this. They find...
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New paper out! #AMPK regulates #ULK1 to balance #mitophagy of functional vs dysfunctional mitochondria in @MolecularCell. Great work from authors, especially Marianna Longo @AnikethBishnu and collaborators @Kei_Sakamoto @CarolMacKintos1. See it here: https://t.co/BVDu2ilrQ9
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We are enormously grateful to the Medical Research Council (MRC)/UKRI for their generous long-term support - 34 years and counting - for our research Unit at the University of Dundee https://t.co/HLj74HAEuN
@The_MRC @UKRI_News #Dundee
ppu.mrc.ac.uk
The government’s Science and Technology Secretary, Peter Kyle, has announced a further five-year funding boost from the Medical Research Council (MRC) to continue our vital work.
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Out Now! Updated story on #HRI kinase as a negative regulator of #PINK1 mitophagy. We now show that the small molecule ISR inhibitor #ISRIB boosts PINK1 activation. Collaboration with @LabGanley @Rousseau_Lab @mrcppu & @GlennMasson Click here for paper https://t.co/DfbKiLM6vc
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Congratulations to Dr Alan Prescott who won first place in the @Official_BSCB image competition It is a set of tiled images taken from a frozen section of an eye from the mitoQC mouse (McWilliams et al. J Cell Biol. 2016) developed by @LabGanley @mrcppu
https://t.co/KGe3ZYJlLJ
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Very excited to share our new article reporting that #PINK1 has an impact on mitochondrial homeostasis and basal levels of #mitophagy in mouse skeletal muscles, enabling to study the pathway in mammalian tissues without overt stresses. @mrcppu @LabGanley
https://t.co/xy9XLyHpaz
tandfonline.com
PINK1, mutated in familial forms of Parkinson’s disease, initiates mitophagy following mitochondrial depolarization. However, it is difficult to monitor this pathway physiologically in mice as loss...
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Congratulations Philippa @philippajane5 on a successful PhD viva! Well deserved🎉🎉🎉! Many thanks to examiners @VIKorolchuk and @amosliang2 too!
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🔬Exciting #JobAlert! 🌟Are you interested in cytoskeletons and their role in organelle biogenesis and autophagy? The @MorelLab4 are on the lookout for a skilled cell biologist to join their dynamic team.🧪 Apply now and be part of cutting-edge research! https://t.co/CYqzRtivkx
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Congratulations Dr Lorentzen on successfully defending your PhD thesis! Well done and we’ll deserved. Thanks also for the super hand knitted mitochondria hat! Many thanks to examiners @FloreyLab and @farnaby84 too!
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We are recruiting! Join the top university in the UK for biological sciences (REF 2021). Appointments for up to 45 Principal Investigators across all career stages (tenure-track to Professorial) are available. Details: https://t.co/uDl3VYnupw
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Many thanks @MorelLab4 for hosting me, the hospitality and showing the great science that is going on @NeckerInem. I really enjoyed my visit!
enlightening and exciting seminar by @LabGanley today @NeckerInem about mitophagy interplay with AMPK and ULK1.. Thank you very much Ian for your visit to INEM!
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Success! First Dundee #Parkinsons patient randomized for Biogen Luminare #LRRK2 kinase inhibitor trial
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Very happy to have been able to contribute to this new understanding of PINK1 regulation! Great work @miratul_neuro
Just out! Our new preprint reporting interplay between the HRI kinase #ISR_pathway and #PINK1 #mitophagy_pathway. New mechanisms of #Parkinsons disease. 🙏@mrcppu lab members and collaborators @GlennMasson @Rousseau_Lab @LabGanley #TeamScience
https://t.co/M3lvzVHv0K
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The Autophagy UK Network Meeting 2023 will be held at University of Birmingham on 19-20 June 2023, organized by @VIKorolchuk and @SarkarSovan, keynotes by David Rubinsztein, @Carmine21678 and @Ivana75154822. Registration link:
autophagyuk389582434.wordpress.com
Visit the post for more.
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Post-doc position available in Simon Wilkinson’s lab! As a current postdoc in this lab myself, I highly recommend it! And Edinburgh is one of the most beautiful cities in the UK! So if you are interested in ER-phagy, apply now! :) #autophagy @WilkoLabLife
https://t.co/kKX5cQlzZx
Looking for a post-doc position? Interested in #ERphagy and #Cancer? Then look no further than @WilkoLabLife who have a @CR_UK funded position in beautiful Edinburgh. See below for link & details... https://t.co/9H8WhkIEcw
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