Bishal Basak
@Basak94Bishal
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Post doc from the Holzbaur lab at UPenn | Former PhD student from RP group at NCBS Bengaluru
Philadelphia, PA
Joined March 2018
New research from @Basak94Bishal & @ErikaHolzbaur reports the identification of a Mitophagic Stress Response ("MitoSR" - mmm, catchy!) activated by mitochondrial damage in neurons & operating in parallel to canonical Pink1/Parkin-dependent mitophagy https://t.co/g5R1o5m3vT
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#CALLFORPAPERS! Do you work on #microtubules or molecular motors in the #brain? If so, we want your papers for a #NEW #SPECIALISSUE in #CYTOSKELETON. โMotors and microtubules in neuronal health and diseaseโ. Submission deadline: Nov. 1, 2025. #FREE to publish.
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Of researchers whose positions depend on grants. You might not think of someone working in a lab when you think about "U.S. jobs" but in fact, there are more grad students in the USA than there are coal miners. You don't fix the economy by taking people's livelihoods away!
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From @TheAthletic: Indiaโs 18-year-old prodigy Gukesh Dommaraju capped his meteoric rise by becoming the youngest world chess champion in history. https://t.co/0gCRa0d8U5
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The emotional moment that 18-year-old Gukesh Dommaraju became the 18th world chess champion ๐ฅฒ๐
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Excited to share my postdoc work, "Autophagic stress activates distinct compensatory secretory pathways in neurons" Now on BioRxiv! https://t.co/u4HCZiIvIf
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Interested in a fully automatic analysis pipeline to quantify and classify your 2D and 3D Single-Molecule Localization Microscopy (SMLM) data in an unbiased way? Have a look at our latest work covering ECLiPSE, developed in the @Melike_Lak lab! https://t.co/2lXkhvOZhJ 1/11
nature.com
Nature Methods - Enhanced Classification of Localized Point clouds by Shape Extraction (ECLiPSE) is a robust feature extraction and classification pipeline for diverse and heterogeneous structures...
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This is beyond possible! Sheetal Devi is poetry in motion. Just 17 years old. Born without arms. A true hero. Congrats India ๐ฎ๐ณ https://t.co/fnthR456uN
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https://t.co/euRm7OgOQI Excited to contribute to this Herculean effort in neuronal protocols spearheaded by Kazu Toyooka! Check it out to find the latest methods used to probe neuronal morphogenesis ๐งซ๐ง ๐ฌ @ErikaHolzbaur @LabToyooka @BatesLab
link.springer.com
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๐ฅณCongratulations to our very own @ErikaHolzbaur for being elected EMBO Associate Member in occasion of the @EMBO 60th Anniversary in recognition of her outstanding work in the filed of organelle dynamics and quality control in neurons!
Outstanding scientists elected to EMBO Membership: in EMBOโs 60th anniversary year, 100 new members and 20 associate members join the community https://t.co/eHCoXY0ynR
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๐ Kapil Dev ๐ MS Dhoni ๐ ๐ฅ๐ผ๐ต๐ถ๐ ๐ฆ๐ต๐ฎ๐ฟ๐บ๐ฎ ๐ฎ๐ณ The Hitman is now a World Cup-winning captain. ๐ท Getty โข #RohitSharma #SAvIND #SAvsIND #T20WorldCup #BallaChalegaCupAaega #TeamIndia #BharatArmy #COTI๐ฎ๐ณ
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Every star added to the Team India jersey inspires our nationโs starry-eyed children to move one step closer to their dreams. India gets the 4th star, our second in @T20WorldCup. Life comes full circle for Indian cricket in the West Indies. From our lows in the 2007 ODI World
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๐๐๐๐๐๐ ๐๐ ๐ ๐๐๐๐ @ImRo45, Iโve witnessed your evolution from a promising youngster to a World Cup-winning captain from close quarters. Your unwavering commitment & exceptional talent have brought immense pride to the nation. Leading ๐ฎ๐ณ to a T20 World Cup ๐ victory
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BALL OF THE TOURNAMENT FROM BUMRAH...!!! - The greatest ever for India! ๐ฎ๐ณ https://t.co/Ft4hUbd96Z
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๐ฃNew @biorxivpreprint from @mito911_! @Basak94Bishal & @ErikaHolzbaur present a new stress response pathway regulating #mitophagy in #neurons through degradation of the autophagy negative regulators MTMR5/2 and Rubicon @ASAP_Research @MichaelJFoxOrg
https://t.co/lXo4Jw6Kad
biorxiv.org
Mutations in genes that regulate mitophagy, a key mitochondrial quality control pathway, are causative for neurological disorders including Parkinsonโs. Here, we identify a novel stress response...
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What happens when neuronal mitochondria are damaged? Our group identifies a novel Mitophagic Stress Response (MitoSR) pathway that accelerates removal of damaged mitochondria via the PINK1/Parkin mechanism. Work funded by ASAP is now online at biorxiv at https://t.co/sY7ZAGI9YB
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India vs Pakistan. New continent, same result ๐ T20 may be a battersโ game, but in New York, bowlers were the Apple of our eyes today.ย What a thrilling match! Great atmosphere and a wonderful exhibition of our great game in America. Well played, India ๐ฎ๐ณ ๐ #INDvPAK
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.@DanTudorica3, @TheHurleyLab et al. @ASAP_Research find that RAB7A phosphorylation in PINK1/Parkin #mitophagy displaces the #autophagy inhibitor Rubicon, whilst recruiting the structurally related positive regulator Pacer. https://t.co/PRDUaa7PP4
@Basak94Bishal @ErikaHolzbaur
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So proud of this beautiful new work from Dan Dou, and so grateful to Virginia Lee for inspiring this study!
Dou, Aiken & @ErikaHolzbaur @PennMedicine show that #Parkinsons disease-associated hyperactive LRRK2 decreases the trafficking of synaptic vesicle proteins within neurons by disrupting the regulation of the synaptic vesicle precursor protein RAB3A. https://t.co/NWKByaYNWm
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