Adam Turner
@adamturner_01
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🇨🇦 Scientist at @GladstoneInst @UCSF Corces lab | Single cell multiomics of 🧠 and ❤️ | University of Ottawa Heart Institute, UVA | Hockey, baseball, soccer
San Francisco, CA
Joined March 2018
CHOIR is now online @NatureGenet! CHOIR is a new clustering method for single-cell data that evaluates whether clusters represent statistically distinct cell populations. CHOIR scales to millions of cells and works with single-/multi-omic data of any type! https://t.co/EKg20yMygH
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Finally got this across the finish line! We made an isogenic panel of MAPT splicing mutation iPSCs that express high levels of endogenous 4R tau... ...and saw some cool stuff! 👇👇👇 https://t.co/2xHJFSx83v Big thanks to supporters @RCFNeuro @_BrightFocus @AFTDHope & @UKDRI!
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🚨Preprint: Stroke recovery is complex & involves major changes to all brain cell types. We dissect underlying molecular mechanisms in the repair phase 1 month post-stroke "A molecular brain atlas reveals cellular shifts during the repair phase of stroke" https://t.co/2tHNz00bno
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Happy to share research from the Corces Lab (led by Shreya Menon and much help from the entire lab) on Multiomics and non coding genetic variants in Parkinson’s Disease #ADPD2024
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New preprint! So excited to present CHOIR, a new clustering method for single-cell data that evaluates whether clusters represent statistically distinct cell populations. CHOIR works with both single- and multi-omic data of any type. Check it out! https://t.co/DvWVFK9xI3
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Long time in the works, new multi-ancestry Parkinson's meta-GWAS. 12 potential novel risk loci, some analyses of heterogeneity across populations and fine-mapping for 6 known loci. Shout outs to all the collaborators! https://t.co/9pRS5AoM7d <- open access
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Now out, our latest work on mapping molecular QTLs in coronary arteries from 138 ancestrally diverse individuals. Led by talented former postdoc @Chani__Bravo, we identify 2.1K eGenes, 1.6K sGenes and refine candidate CAD risk mechanisms. 1/n https://t.co/0IE1VgA4eZ
@CellGenomics
cell.com
Hodonsky et al. perform gene expression profiling and a multifaceted genetic analysis of gene regulation in coronary artery tissues from an ancestrally diverse patient cohort. This new resource...
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Excited to finally share #MetaPlaq v1, an integrated atlas of human atherosclerosis containing ~118K cells from coronary and carotid arteries, now out in @CellReports. Very proud of talented PhD student Jose Verdezoto Mosquera who led this study. 1/n
cell.com
The authors generate a comprehensive map of cell diversity in human atherosclerosis. This atlas provides insights into the heterogeneity of smooth muscle cells and their genetic contribution to...
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Thrilled to share our latest on mapping new genetic risk loci for coronary artery calcification (CAC), now out @NatureGenet. A colossal effort, but fun collaboration with several groups led by @maryamkavousi, Pat Peyser, @Raj_MalhotraMD, @swvanderlaan
nature.com
Nature Genetics - Multi-ancestry genome-wide association meta-analysis identifies new risk loci for CAC. Functional evidence implicates candidate causal genes as regulators of smooth muscle...
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The #RasheedLab website is up & running! https://t.co/TrqVZ1TNro
@ImmunologyAU If you love lipids, immune cells and want to join a team #onacholesteroll, we are currently recruiting postdoctoral fellows and a research manager/associate. Pls RT!
augusta.edu
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Noncanonical binding of transcription factors: time to revisit specificity? [review by Md. Abul Hassan Samee] https://t.co/2Avi7p7BV3 ▶️DNA shape recognition ▶️G-quadruplexes ▶️DNA sequence repeats ▶️Bispecific binding
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Presenting mubind, a new method at @fabian_theis lab to learn scATAC-seq using seq features and graph representations e.g. kNN-graphs for cell-cell communication. With it, we can learn motif features linked with local cell transitions #ISMBECCB2023 [1/3] https://t.co/n5wyWlcTSm
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Annotating and prioritizing human non-coding variants with RegulomeDB v.2. #NonCodingVariants #VariantsAnnotation #VariantsPrioritization @NatureGenet
https://t.co/CW0PXHF0dK
nature.com
Nature Genetics - Annotating and prioritizing human non-coding variants with RegulomeDB v.2
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Vascular #SmoothMuscleCell dysfunction in #Neurodegeneration Vasculo-neuronal-inflammatory triad Hypercontractile VSMC ⏬Clearance receptors for Aβ Autoimmune-related SMC degeneration in #AlzheimersDisease Dr. Genevieve Hayes lab @FrontNeurosci 2022 https://t.co/TNliKrDiHN
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Just in time for #ASHG22..check out our recent work to create an integrated single-cell atlas for atherosclerosis in humans, led by talented PhD student Jose Verdezoto Mosquera. Reach out if interested in joining our dynamic group!
biorxiv.org
Atherosclerosis is a complex inflammatory process driven by plaque formation in the major elastic arteries and often leads to reduced blood flow, coronary artery disease (CAD), myocardial infarction...
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The line-up for the @UVACPHG 's first annual "Hot Puns" event, featuring hot wings, 12 homemade(!) hot sauces from @Chani__Bravo, and too many science puns, including: HOTHOT Box Yum-manaka Factor FLOXED AND LOADED Receptor Tyrosine Cry-nase, and Cysteines Don't Fear the Reaper
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Very excited to share SELMA, a computational method we developed for ATAC-seq & DNase-seq bias estimation, recently published in @NatureComms spearheaded by @ShengenShawnHu w input from @zozolaki @liul_stoch_stat @guertinlab Ke Deng & Tingting Zhang
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Very excited to share this labor of love… and (hopefully) new therapeutic target for #Parkinsons GPNMB confers risk for Parkinson’s disease through interaction with α-synuclein
science.org
Computational, cell biological, and human tissue-based studies establish GPNMB as a risk gene and therapeutic target for Parkinson’s disease.
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