Landmark revisit Gut microbiota-Artery axis Ectopic non-nasal Olfactory Receptor #ShortChainFattyAcid Propionate activates Olfr78/OR51E2 (& GPR41 GPR43) on #SmoothMusclecell in resistance arteries/arterioles (kidney/heart/diaphragm)➡️ Vasodilation Hypotension Antibiotic combo

Decellularized #TissueEngineeredVascularGraft #hiPSC-#SmoothMuscleCell seeded on PGA tubular scaffold (φ3 mm) ⏩ CHAPS/EDTA/SDS decellularization Rupture pressure 1200 mmHg Suture retention strength 120 g Re-endothelialized⏩ nude rat aortic graft for 30 d No thrombogenesis

#SmoothMuscleCell #Piezo1 #Hypertension #HydrostaticPressure (200 mmHg), Not #CyclicStretch (18% strain 1 Hz)➡️ ⏫GPR146 (+⏬GPR4) in SMC➡️ ⏫SMC synthetic phenotype ⏫Cardiomyocyte hypertrophy ⏫cAMP-CREB-Piezo1 (also TRPV4 & KCNK4)➡️ ⏫Systolic & Diastolic Blood Pressure

#Atherosclerosis Epitranscriptomics Cell type-specific dysregulation of m6A machinery in pro-atherogenic phenotypes of #EndothelialCell (ALKBH5) #SmoothMuscleCell (WTAP) Mφ (METTL3 YTHDF2) Re-analysis of scRNAseq Wirka's Nat Med 2019 https://t.co/3YbAS1eQVe @THNOdotORG 2025

#VascularCalcification DNA N6-methyladenine/6mA (NOT m6A) of BMP2 gene ⏬OCT4-dependent transcription & #SmoothMuscleCell Calcification ALKBH1, an eraser of 6mA ⬇️in calcified radial artery of👤CKD ⏫aortic calcification in 🐭+Adenine diet @jclinicalinvest 2021

#SmoothMuscleCell #Piezo1 is required for small intestinal motility SMC Piezo1 KO in 4~6 wk-old🐭 👉Muscularis thinning 👉⏬Food consumption 👉⏬SMC density w/o⏫apoptosis 👉⏬small intestinal motility 👉⏬Muscularis Orai1/3 Trpc4 IP3R ⏫Cav1.2 Ano1 👉⏬carbachol-induced tension

#WernerSyndrome hiPSC-derived engineered vessel #SpatialTranscriptomics #Visium @10xGenomics + #Metabolomics▶️ #BranchedChainKetoAcid⬇️ #MonohydroxyFattyAcid⬆️ in Werner vessels with traits of #PrematureAging Aligned #SmoothMuscleCell in Collagen hydrogel➡️ Roll-up around φ

#VascularCalcification #SmoothMuscleCell NAMPT-SIRT1 axis, via suppressing Notch-HES1 signaling, protects against aortic medial calcification in 🐭VitD3 or CKD @atvbahajournals 2025 https://t.co/rXugsNnIOR

#Colchicine alleviates #AbdominalAorticAneurysm ApoE−/− mice +ANGII Effects on Macrophage (down NLRP3 IL-1β TNFα MCP1) & #SmoothMuscleCell (up LOX TIMP1/2) Unaltered aortic MMP2/9 Yuji Narita lab #CircJ 2025 https://t.co/NwXK8KEuIb

A workflow to optimize siRNA targeting SMILR #LncRNA & #SmoothMuscleCell proliferation/migration ex vivo 30 min siRNA exposure is sufficient to penetrate ~10 lamellar layers of explanted saphenous vein media Polyethylenimine as siRNA delivery agent Andrew Baker lab #JACCBTS

Single-cell transcriptomics #SuperficialTemporalArtery #MoyamoyaDisease 2 Case + 3 Ctrl (epilepsy) SMC1: contractile OXPHOS SMC2: ribosome Proliferative signaling ✅#NaturalKiller MIF➡️#SmoothMuscleCell Fibroblast ❓#NaturalKiller TNF➡️#SmoothMuscleCell Fibroblast

Deep subclustering of #SmoothMuscleCell Fibroblast Macrophage in👤🐭#Atherosclerosis Human: scRNAseq (n=21) + CITEseq 274 antibodies (n=6) sciPENN #DeepLearning Universal surface markers of👤SMC CD49a/ITGA1 CD146/MCAM CD29/ITGB1 EGFR CD90/Thy1⬆️ CD142/F3⬇️ in modulated SMC

#AllograftVasculopathy TET2 #DNADemethylase #MethylcytosineDioxygenase, an epigenomic defender of #SmoothMuscleCell contractile phenotype ⏬Interferon IFNγ signaling in SMC Dedifferentiation, apoptosis - is this myocardin/SRF-dependent?😆 Ascorbic acid (4 mg/kg/d) ⏫TET2

Histone Variants underlie #SmoothMuscleCell phenotypic plasticity 1⃣H2A.Z (⬇️in #Atherosclerosis, enriches at nucleosome associated with accessible chromatin regions downstream of TSS) ⏫SMC contractile gene via recruiting SMAD3 & MED1 @CircAHA 2018 https://t.co/MTIpyFHjSA

#Cohesinopathy BRD4 (acetyl lysine reader)-NIPBL (cohesin loading ) complex is critical to #NeuralCrest differentiation into #SmoothMuscleCell BRD4 depletion->#GenomeFolding+loop extrusion BRD4 in #AorticAneurysm? Dr. Rajan Jain lab ⏬@NatureGenet 2021 https://t.co/TL9qo5xz2w

Non-hepatic #PCSK9 PCSK9 overexpression regulates #ExtracellularVescle cargo packaging (#Proteome microRNA array) in #SmoothMuscleCell▶️ 👉⏫Inflammation in #EndothelialCell Mφ in vitro 👉⏫Migration ⏫oxLDL uptake ⏬OXPHOS ⏫Glycolysis in Mφ in vitro 👉Recruit more Mφ when

#SmoothMuscleCell m6A Epitranscriptomics METTL3 ⏫in human #ArterioVenousFistula stenosis SMC Mettl3 KO🐭 ⏬#IntimalHyperplasia at AVF Mettl3-YTHDF1 stabilizes SLC7A11 mRNA➡️ ⏬SMC contractile phenotype ⏫SMC proliferation/migration ⏬Lipid peroxidation Ferroptotic death?🧐

Please join @StanfordCVI seminar Tue 2/21 at 12-1pm PST by Dr. Thomas Quertermous talk on #Genetics of #SmoothMuscleCell #CoronaryArteryDisease Zoom link: https://t.co/oD1xyw95rv @StanfordDeptMed @Stanford_ChEMH @VascularBiol @SeanM_Wu @CardioNerds @ATVBCouncil @StanCVFellows

Tie2+ #EndothelialCell- or Col1A2+ fibroblast-derived C-type Natriuretic Peptide protects against #AorticAneurysm in Apoe-/- mice + AngII + AAV-PCSK9 + #WesternDiet #SmoothMuscleCell & Mφ are responsive to exogenous CNP @Dr_A_cubed @atvbahajournals 2025 https://t.co/TDIFLAXijK

Science photos for sale https://t.co/kC74fkUqzX #Embryonic #smoothMuscleCell #NationalInstituteOfHealth #NIDCR #Wallart #Anatomy #Science