Vishwa Deep Dixit
@VishwaDeepDixi1
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Joined January 2018
Very interesting paper on the history of Treg and the many contributions of those recognized but also, importantly, of those not recognized by the @NobelPrize || The history and promise of Treg cells
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Online now!✨RESEARCH: @inhwajang_ et al show that GDF3 drives endotoxic inflammation and lethality in old mice by reshaping chromatin in inflammatory adipose tissue macrophages @CamellChristina
nature.com
Nature Aging - Jang and colleagues demonstrate that GDF3 reshapes the chromatin landscape of inflammatory adipose tissue macrophages and drives endotoxic inflammation with age. Pharmacological...
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The GDF3–SMAD2/3 axis as a critical driver of age-associated chromatin remodeling adipose tissue macrophage-mediated inflammation and a promising therapeutic target for mitigating macrophage-related inflammation in #aging
nature.com
Nature Aging - Jang and colleagues demonstrate that GDF3 reshapes the chromatin landscape of inflammatory adipose tissue macrophages and drives endotoxic inflammation with age. Pharmacological...
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Top #Citations 2025: 5️⃣ @VishwaDeepDixi1et al (@YaleMed) show that cysteine depletion leads to adipose tissue browning and rapid weight loss in mice and humans. https://t.co/CzGlZTT0cq
nature.com
Nature Metabolism - The authors describe how reduced dietary availability and systemic loss of cysteine leads to adipose tissue browning and rapid weight loss in mice and humans.
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🚨 Save $200 when you register for Immunometabolism Across Scales by Nov 12 (11:59pm MST)! Plus, get free access to From Systems Immunology to Immunoengineering! 🔗 https://t.co/agxRM2zGRG
@Tcellogic @VishwaDeepDixi1 @QuinaScience
#KSImmunoMetab26 #immunometabolism
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Thrilled see our paper out in @Nature ! 🤩 Wonderful collaboration with @GoCasteloBranco. Kudos to my amazing postdoc @Di_0579 at @YaleEngineering and Leslie Kirby from Goncalo's lab @karolinskainst. Huge team science with @YaleMed @UCSF @ASTARsg
https://t.co/IF7XbnS1q0
nature.com
Nature - A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.
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Just out - our major review piece @ImmunityCP , summarizing couple of decades of the research on human immune aging and providing highlights of the latest advances in the field. Led by Marina Terekhova, truly encyclopedic depth (327 references) https://t.co/4SenJ8VTOj
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Congratulations to @YaleAge member Tamas Horvath, DVM, PhD, (right) chair & Jean & David W. Wallace Professor of Comparative Medicine @YaleMed, on being selected to @theNAMedicine along w/Martina Brueckner, MD & Lieping Chen, MD, PhD. https://t.co/qxFEp7ai7S
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Sasha Rudensky - “The Treg master” A wonderful write up on the scientist who has elucidated so many nuances in Treg function and biology, including and especially in the context of cancer. https://t.co/TGBbxndtFW
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“Inflammaging” — chronic, low-grade inflammation that rises with age — is now seen as a key driver of aging & age-related diseases. Experts say managing blood sugar, sleep, and visceral fat can help slow it down. 🔗 https://t.co/hDgznwbGvD
#HealthyAging #Longevity
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The @Langston_Lab of @YaleMed seeks a highly motivated Postgraduate Associate in exercise immunology. One of the lab’s goals is to elucidate how immune cells sense exercise and regulate its benefits. Come work with the best. #PathologyJobs
https://t.co/d3eJJurHUE
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We’re just two weeks from The 2nd Yale Center for Research on Aging (Y-Age) Symposium. It’s Monday, October 13 at the Anlyan Center Auditorium at @YaleMed. Join us for a day-long discussion on human longevity, geroscience, and the biology of #aging. https://t.co/EbPTo6CZ67
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Study, whose authors include @VishwaDeepDixi1 of @YalePathology & @YaleMed, finds that certain immune cells that regulate fat metabolism & control age-related inflammation decline during #aging. https://t.co/mbUY0UsPTu
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Excited to share a new paper and online resource from our lab published today. We developed a mass spectrometry approach that leverages genetic diversity to systematically nominate functional relationships between metabolites and proteins.
nature.com
Nature - A mass spectrometry-based approach globally identifies protein regulators of metabolism and reveals the role of LRRC58 in controlling cysteine catabolism.
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The 2nd Yale Center for Research on Aging (Y-Age) Symposium is set for Monday, October 13 at the Anlyan Center Auditorium at @YaleMed. Join us for a day-long discussion on human longevity, geroscience, and the biology of #aging. https://t.co/EbPTo6CZ67
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#NatMetabPicks | In @NatureAging led by @VishwaDeepDixi1 (@YaleMed) A subpopulation of nerve-associated macrophages that regulates inflammation and lipolysis declines in the adipose tissue with age. https://t.co/yjUL2NpXzS
nature.com
Nature Aging - Gonzalez-Hurtado, Leveau and colleagues characterize adipose resident tissue macrophages across lifespan in mice, finding that nerve-associated macrophages, which mitigate...
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💥#ImmunometabolismPower! Excited to have this officially out @ImmunityCP💥 Pathogens induce the host to produce oxidized lipids which rewire #macrophage #metabolism, causing #epigenetic modifications which dampen interleukin-10, exacerbating inflammation!
cell.com
Upon pathogen detection, phagocytes trigger immunity. This process induces tissue stress and the formation of host-derived molecules that further tune immune responses. We show that host-derived...
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An NLRP3 stimulatory universal influenza vaccine. We report an NLRP3 stimulus that generates hyperactive dendritic cells (hDCs). https://t.co/oFcCIyyanc
journals.asm.org
The generation of vaccines that stimulate T cell activities is an unmet need for the scientific community, as T cells are the primary mediators of immune memory. In this study, we report a new...
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Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related inflammation. @NatureAging Open Access https://t.co/t7zuDR4JlR
A newly discovered type of immune cell found in fat tissue seems to contribute to the chronic inflammation associated with ageing. @Nature
https://t.co/I8COCaZi2L
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Newfound immune cell in mice hints at why inflammation spikes with old age
nature.com
Nature - Pathogen-consuming cells found in fat tissue also play a part in lipid balance.
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