Tine Tesovnik
@Tine_Tes
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#epigenetics, #NGS, #snRNA, #miRNA, #EVs, #exosomes, #telomere, #T1D research, #genetics 🧬
Slovenia🇸🇮🇪🇺
Joined February 2018
Important first-in-human report today for donor pancreatic islet beta-cell transplant to an individual w/Type 1 diabetes. With genome editing of the cells, there was no immune response induced or need for immunosuppression. Major implications for transplantation in general @NEJM
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Scientists have found a new way to recreate inner ear hair cells in the lab to study hearing loss. https://t.co/F4bzz2x6U0
#DevBio #CellBio
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Metformin, the first line drug for Type 2 diabetes, has been used for 60 years without a clearcut mechanism of action. It turns out it's not just reducing glucose output from the liver. Metformin also works via the brain
science.org
Metformin lowers blood glucose by inhibiting Rap1 in ventromedial hypothalamic neurons that regulate glucose balance.
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Weekly recap: Long-read consensus assembly with Autocycler, Progen3 for generation and functional understanding of proteins, CarpeDeam for ancient metagenome assembly, hifiasm ONT for T2T assembly of Simplex reads https://t.co/QGIJol6ZmN
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Wow – this could become (I think) the first miRNA therapeutic It increases miR‑124 levels – mainly in immune cells miR‑124, in turn, prevents the translation of a range of of inflammatory proteins (STAT3 and IL6R – T cells and MCP‑1 /CCL2 – macrophages)
Abivax $ABVX shares up over 550% as ulcerative colitis drug scores two Phase 3 wins! https://t.co/YaIpjb79Jt
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How GLP-1s Are Breaking Life Insurance
glp1digest.com
Patients look healthy on paper. Two years later, they're high-risk again.
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#StemCell therapies for #diabetes have entered the clinic; our latest Review summarizes the advances that got us here, lessons learned from early trials & the clinical, manufacturing & regulatory challenges that must now be overcome https://t.co/vlFlvRpidf
nature.com
Nature Medicine - Advances in beta cell differentiation have propelled cell therapies for diabetes into the clinic; this Review outlines the lessons learned from early-phase trials and discusses...
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1/3rd of US teens (>8 million kids) have prediabetes https://t.co/XPdD1EBSa1
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DNA methylation protects cancer cells against senescence https://t.co/qCAjcbkOOa
nature.com
Nature Communications - Using degron approaches, the authors show that cancer cells experiencing prolonged DNA methylation loss—without substantial DNA damage—undergo non-canonical...
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PanVA: a visual analytics tool for pangenomic variant analysis. #Pangenomes #VariantAnalysis #DataVisualization #Genomics #Bioinformatics @biorxiv_bioinfo
https://t.co/VCKDGfO0tT
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People started talking seriously about sequencing every newborn about 16 years ago. Here it is (maybe).
telegraph.co.uk
Advances will allow people to avoid fatal diseases and receive personalised health care
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Marcel Nelen, UMC Utrecht. Must get to 30X on single flowcell without washing & reloading for ISO certification as those introduce risk of sample swap
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Genetically engineered bacteria make animal-free insulin. Tens of millions of lives have been saved. This is the power of biotechnology: Less waste. More efficiency. Accessible, sustainable medicine.
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New online! Reactivation of retrotransposable elements is associated with environmental stress and ageing https://t.co/naq5EHgKKM
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My first podcast 🤩 Thank you Liam Hourigan and @SNEVresearch for the invitation and for making it such an enjoyable experience 🙏 I hope #extracellularvesicles enthusiasts and beyond find it helpful 😁
🎙️ New SNEV Podcast Episode: “The EV Biomolecular Corona and Organising with ISEV” 🎙️ Join us as we listen to @LenassiMetka as she dives into her latest research on EVs and HIV, and also being a member on the executive board of ISEV. Play it here: https://t.co/GezNZM9Cb3
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Review: The epigenetic landscape of fate decisions in T cells
nature.com
Nature Immunology - Vahedi and colleagues review the mechanisms shaping the epigenetic landscape of CD4+ and CD8+ T cells during development and differentiation.
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Jimmy Page wanted to be a biological researcher …
Jimmy Page at the age of 13. What nobody expected was that this child would become one of the greatest guitarists in Rock History…
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Our paper just published on Early Deaths of Neonates with Fatty Acid Oxidation Disorders https://t.co/SgwnWGJTpv
#mdpiIJNS @IJNS_MDPI
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A new mechanism for cancer-induced immune evasion. We knew about cancer cells hijacking mitochondria. Now we learn about how their mitochondrial transfer to T cells impairs the tumor immune response. https://t.co/TzEnpmvwUy
@Nature
https://t.co/LzYMXKeS7A
@NatureNV
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