Li Tang
@Tang_Lab_EPFL
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#Immunoengineering for better therapies | Associate Prof. of BioE @EPFL | Associate Editor @ESMO_IOTECH | Co-founder of @LemanBiotech
Lausanne, Switzerland
Joined May 2021
Thrilled to share our back-to-back two Nature @Nature papers on the unexpected role of type 2 immunity against cancer. We found that interleukin 4 (Fc–IL-4), a type 2 cytokine, reinvigorates exhausted T cells to potentiate anticancer immunotherapy w/ @YugangGUO2 @RongFan8(1/11)
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Beyond excited to share our #NewPaper in @CellCellPress! Inflamed environments acidify intracellular pH. BRD4 senses this via transcriptional condensates, tuning #macrophage responses to match demand and consequences of inflammation. #inflammation #pH
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Excited to attend and speak at FOCIS 20225 next week! @Focis_FCE @focisimmunology #FOCIS #FOCIS2025
https://t.co/rHSxVAigpU
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The Yin-Yang of metabolic modulation for improving cancer immunotherapy - check our most recent review article on metabolic immunoengineering! Kudos to my former postdoc Bing Feng, now PI at Hangzhou Inst of Medicine, and PhD students Rongrong @RRLi11606739 and Weilin @Weiliin_L
Feng et al. discuss the metabolic characteristics of tumor-infiltrating lymphocytes and innovative metabolic immunoengineering approaches to improve cancer treatment outcomes @Tang_Lab_EPFL
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We are excited to kick off our Forces at Play: Molecular Mechanobiology Seminar Series with Dr. Cheng Zhu from the Georgia Institute of Technology on January 16th at 12pm EST. If you aren't already on our distribution list, please register below for the Zoom link!
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Many congratulations to Michele! @Materials_EPFL @MicheleCeriotti
Congratulations to @MicheleCeriotti for delivering his E. Bright Wilson Prize Lecture on machine learning for chemistry at @HarvardCCB! https://t.co/yjUWxonhhV
#chemtwitter
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Interested in working with 🐸, 🐭, stem cells, or computational methods 🖥️ to delve into the unknowns of regeneration in our new lab? Looking forward to enthusiastic and ambitious applicants! PhD program applications open! 🔗 https://t.co/eEBR4ot6Ty Please RT! 🙌
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Beautiful illustration of E-CAR T cell👍A new way to engineer CAR T cells. Congrats, Chenqi, Haopeng, and the team👏
Glad to share our new publication @ImmunityCP , reporting a new E-CAR that can form mature immunological synapse through phase separation. Paper link: https://t.co/CsQrN2fzNA
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Interested in #singlecell and #spatial #metabolomics ? Then book your calendar for December 10th! – Our online, free event will summarize major achievements of the field in 2024. #metabolism #omics #MALDI #EPFL With @Gio_Dangel0 lab we prepared a fantastic lineup. 🧵 1/5
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#ScienceSaturday ❓ How can we enhance CAR-T cell activity against solid cancers? ➡️ In a recent study, Zhao et al transduced CAR-T to express IL-10, resulting in enhanced T-cell proliferation, effector function, mitochondrial capacity and antitumor activity in a variety of
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This cover art was based on real TEM images of mitochondria of exhausted CAR-T cells reinvigorated by IL-10. Kudos to Yiling Li, a PhD student of my former postdoc, Prof. Yugang Guo @YugangGUO2 @ZJU_China
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Credit to Vincent van Gogh as we were inspired by his famous painting 'The Starry Night' obviously 😀
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We make it to the cover @NatureBiotech! the IL-10-CAR-T cells eradicate solid tumors! https://t.co/hpFUqyuRGD The IL-10-CD19-CAR-T cells have shown promising clinical results in several investigator initiated trials too. Stay tuned! #SOHC @myESMO @ASH_hematology
nature.com
Nature Biotechnology - CAR T cells engineered to express IL-10 eradicate solid tumors and metastases.
The November issue is live https://t.co/Oh3jSUkWXw On our cover, Zhao et al. show that expressing IL-10 in CAR T cells improves their mitochondrial function and therapeutic efficacy in multiple solid-tumor models https://t.co/Sg45YuyQx3
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Heading to PEGS Europe. will share our recent discovery of IL-10 CAR-T cells to treat blood and solid cancers!
Attendee list preview for #PEGSEurope now available! https://t.co/bQ9sIQyQYW More than 1500 attendees are expected in Barcelona for the "best #biologics technology meeting in Europe." Book by Friday and you can still save €400. #antibodies #proteinengineering #immunotherapy
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Our new study published today @Nature uncovers that Transgelin 2 preserves T cell lipid metabolism and anti-tumor activity. Transgelin 2 is silenced in dysfunctional TILs, and restoring its expression enhances CAR-T cell therapy in #OvarianCancer 👇 https://t.co/JzFY5OQ2Hx
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Doing research in Surface and lnterface Science & Tribology, and want to join @Materials_EPFL @EPFL_en? Send your application by December 1st! All info here: https://t.co/WHjibpF9W0
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Are you looking for a Faculty Position in Surface and lnterface Science & Tribology? The School of Engineering and The School of Basic Sciences at @EPFL_en are hiring! Check out the job description for more details: https://t.co/RF6irIalcj
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A nice report by EPFL too! Thanks, Celia and Alain! “Unexpected immune response may hold key to long-term cancer remission”， https://t.co/UpntVTeOz2
actu.epfl.ch
Results from a preclinical study in mice, led by EPFL, and a collaborative clinical study in patients show that the type 2 immune response – associated with parasitic infection and thought to play a...
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Exciting opportunity! Faculty Position of Metabolism at Tenure Track Assistant Professor level at EPFL. deadline is approaching. please spread the word.
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An Fc–IL-4 fusion protein reprogrammed cellular metabolism in terminally exhausted T cells in tumors, leading to enhanced cellular survival, cytotoxicity, and antitumor immunity. Read our summary here 👇 https://t.co/oz8UzCmbrL @Tang_Lab_EPFL @YugangGUO2 @RongFan8 @GruppSteve
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