Dylan Ryan
@RyanLab_TCD
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Assistant Professor in Trinity College Dublin. A mitochondria and immunometabolism enthusiast. 🦋 @ryanlab.bsky.social
Dublin City, Ireland
Joined August 2021
📢Last 2 weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️ https://t.co/dGFH4FWKIb
https://t.co/tX4tBBAz1b Highlights: Species-specific serine metabolism differentially controls natural killer cell functions https://t.co/tG76GvayNC
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Don't forget to register and submit your abstract for our #MitoCellFate conference in Malta next year 🇲🇹 📢Check out our wonderful speaker line-up so far! 📅Early-bird & talk deadline: 10 Nov 2025 🔗 https://t.co/sI5o7MnA3G
#FusionStemCells #FusionAgingResearch
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In vivo itaconate tracing reveals degradation pathway and turnover kinetics
nature.com
Nature Metabolism - In this study, Willenbockel et al. trace circulating itaconate in vivo to gain insight into its fate and systemic metabolism.
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📢Last 2 weeks of #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️ https://t.co/a1gcoATpsf
https://t.co/6pYBur25hj Highlight: Nrf2 drives activation-driven expansion of CD4+T cells by modulating glucose and glutamine metabolism
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Replication competition drives the selective mtDNA inheritance in Drosophila ovary
cell.com
Zhang et al. report a novel imaging method that can distinguish mtDNA variants with single-nucleotide polymorphisms at single-molecule resolution in situ. Using this method, they visualized dynamics...
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The postdoc paradox: a career without a path https://t.co/iFpVYMf7gO
academic.oup.com
Pansieri et al. explore the ‘postdoc paradox’, whereby a role designed to launch careers now stalls them. With insufficient recognition and no clear career
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💚 Leigh Syndrome Awareness Day is almost here! Sep 17 - Join us in raising awareness and the urgent need for research and hope. Share with us some ways you plan to raise awareness in the comments! https://t.co/4CDInnBVZK
#LeighSyndrome
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Can you rejuvenate an old brain by giving it young immune cells? 🧠 My lab @calico put it to the test. In our new study, we replaced the brain's immune cells in old mice with young ones. The result? The old brain environment forced the young cells to age RAPIDLY. A 🧵👇
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METTL1-mediated m7G methylation of Sarm1 mRNA promotes macrophage inflammatory responses and multiple organ injury | @SciImmunology
science.org
METTL1-mediated m7G modification enhances macrophage proinflammatory responses by promoting SARM1-induced NAD+ decline.
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Wonderful selections of papers on #MitochondrialDisease from #week35 and #week36! 📚 https://t.co/ZoAXi5JpHA
https://t.co/aHWVkLFxua
@Bims_BiomedNews @gavinmcstay2 @mitoscientist RTN4IP1 is required for the final stages of mitochondrial complex I assembly and CoQ biosynthesis
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Heme allocation in eukaryotic cells relies on mitochondrial heme export through FLVCR1b to cytosolic GAPDH | Nature Communications https://t.co/SCyi81lV1E
nature.com
Nature Communications - Heme is an iron-containing molecule made in mitochondria. The study shows that FLVCR1b and TANGO2 proteins export mitochondrial heme to GAPDH in the cytosol and this allows...
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And thus, TRANSLONOMICS was born!
A large consortium of researchers introduces the term 'translon' to denote any transcriptome region that is decoded by ribosomes. https://t.co/b2uC7C5zvm
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A common type of ant in Europe breaks a fundamental rule in biology: its queens can produce male offspring that are a whole different species https://t.co/2vgdjcuFPH
nature.com
Nature - Ant queens of one species clone ants of another to create hybrid workers that do their bidding.
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#MycobiotaPower! Exciting work @Nature by Behnsen, Jaswal &co showing that #Salmonella uses type 3 secretion system to hijack #Candida_albicans to produce arginine in the gut, boosting Salmonella infectivity & reducing the immune response!
nature.com
Nature - Commensal Candida albicans enhances the virulence and dissemination of Salmonella enterica subsp. enterica serovar Typhimurium.
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Big personal news. I'm proud to announce I've returned home to Ireland to start a tenure track Assistant Professorship in the School of Biochemistry and Immunology @tcdTBSI @tcddublin today. Back to where my love for #immunometabolism started, an exciting new career chapter!
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Unlocking longevity through the comparative biology of aging https://t.co/yRfCCZBeeA
nature.com
Nature Aging - Rechsteiner and colleagues explore how studying lifespan and disease resistance across species reveals natural adaptations that promote longevity. The authors summarize new...
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Metformin alters mitochondria-related metabolism and enhances human oligodendrocyte function
nature.com
Nature Communications - Metformin is under clinical trial for brain neuroprotection but how it may work is poorly understood. Here, the authors show that metformin helps myelin formation by human...
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Protein(s): IRG1/ACOD1 + TCA cycle enzymes Function: Anti-microbial activity & immunomodulation. Behaviour: Release of mitochondrial nucleic acids (DAMPs) during infection, which synergise with PAMPs to regulate innate immune response. #Immunometabolism #mitochondria
What is your favorite mitochondrial function, protein, or behavior that fascinates you in health or disease? 🤍💚
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