Catalina Vasilescu, PhD
@_CVasilescu
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I write about mitochondrial research | Biomedical scientist, PhD from @ASW_Lab, Postdoc with @ProkischLab
Munich, Bavaria
Joined November 2017
Last two weeks of literature relevant for #MitochondrialDisease! 📚 . @Bims_BiomedNews @gavinmcstay2 @mitoscientist @MitoSociety @mitoscientists . Please browse the collections here! 👇.
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RT @gavinmcstay2: Integrating Mitochondrial Toxicity Screening Into Early Drug Discovery | Technology Networks
technologynetworks.com
In this Teach Me in 10 episode, Julie Eakins, Principal Scientist at Cyprotex, discusses the importance of integrating mitochondrial toxicity screening into early drug discovery and the range of...
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Allele frequency selection and no age-related increase in human oocyte mitochondrial mutations | Science Advances.
science.org
Human oocyte mtDNA mutations do not increase with age and are selected against changes to minimize functional consequences.
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Amyloid fibril structures link CHCHD10 and CHCHD2 to neurodegeneration | Nature Communications.
nature.com
Nature Communications - Lv et al. discover that homologous disordered regions of proteins linked to ALS/FTD and Parkinson’s, CHCHD10 and CHCHD2, form amyloid fibrils in vitro and that the...
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Saturated lipid stress attenuates mitochondrial genome synthesis in human cells | bioRxiv.
biorxiv.org
Fatty acids are trafficked between organelles to support membrane biogenesis and act as signaling molecules to rewire cellular metabolism in response to starvation, overnutrition, and environmental...
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Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo | Nature Communications.
nature.com
Nature Communications - Here they show that mitochondria segregate unequally during asymmetric cell division in C. elegans and that this is dependent on mitochondrial dynamics. Unequal...
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#MitochondrialDisease collection of papers from #week32! đź“š. @Bims_BiomedNews @gavinmcstay2 @mitoscientist @MitoSociety @MitoSenseInc . Highlights. Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson's disease
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RT @VamsiMootha: Hypoxia as a therapy for Parkinson's disease! New study w/ @FumitoIchinose shows PD mice have brain hyperoxia. Chronic 11%….
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RT @jenheemstra: Labwork to Leadership officially released today!!. I'm humbled by the support from our community, as it's already sold out….
hup.harvard.edu
A roadmap for running a lab—and developing the leadership skills you didn’t know you needed.As a graduate student and postdoctoral researcher, chemist Jen Heemstra learned how to collect data, write...
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RT @RyanLab_MBU: It was a pleasure to write this News & Views piece with @EloiseMLMrqs on the latest work from the lab of Jing Fan @NatMeta….
nature.com
Nature Metabolism - Metabolic reprogramming is a well-established hallmark of macrophage activation, coordinating bioenergetic and biosynthetic pathways to support immune effector functions. A new...
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Structural basis for promoter recognition and transcription factor binding and release in human mitochondria - ScienceDirect.
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Oligomer-based functions of mitochondrial porin | Nature Communications.
nature.com
Nature Communications - Cryo-EM structure of yeast Por1 hexamer reveals functions beyond metabolite and ion transport, including regulation of protein import via Tom22, maintaining lipid...
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Metabolic Adaptation of Regenerative Hematopoiesis Depends on Docking-Independent Mitochondrial Connexin-43 | Blood | American Society of Hematology.
ashpublications.org
Key Points. Antioxidant activity of Cx43 depends on its autonomous activity in mitochondria of hematopoietic stem cells and multipotential progenitors.Cx43
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Opantimirs: A class of antagonizing microRNAs that upregulate Opa1 and improve mitochondrial and disuse myopathies: Cell Reports Medicine.
cell.com
Djalalvandi et al. show that blockers of Opa1-targeting microRNAs found upregulated in diseased skeletal muscle can restore mitochondrial architecture and muscle performance in mitochondrial myopathy...
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Human mitochondrial RNA polymerase structures reveal transcription start site and slippage mechanism - ScienceDirect.
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Wonderful selection of papers on #MitochondrialDisease from #week31!. @Bims_BiomedNews @gavinmcstay2 @mitoscientist @MitoSociety. Highlights.2-hydroxyglutarate mediates whitening of brown adipocytes.
nature.com
Nature Metabolism - CLPP-deficiency-driven mitochondrial dysfunction in brown adipose tissue leads to the accumulation of d-2-hydroxyglutarate, in turn promoting lipid-droplet enlargement by...
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RT @BarteltLab: We wrote a thing on mitochondrial coupled versus uncoupled respiration 🔥 .
onlinelibrary.wiley.com
Brown adipose tissue (BAT) mediates non-shivering thermogenesis (NST) through activation of uncoupling protein 1 (UCP1). Due to the uncoupled nature of BAT, oxidative phosphorylation is an underapp...
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RT @jourdainlab: Our updated inventory of genes required for #OXPHOS & findings on #mito defects in #Menieres is now out at @CellReports! 🎉….
cell.com
Harhai and collaborators expand the catalog of genes essential for oxidative phosphorylation and implicate FAM136A in mitochondrial proteostasis. Their findings suggest a mitochondrial contribution...
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@SwagatSPradhan The mammalian protein MTCH1 can function as an insertase | Journal of Cell Science | The Company of Biologists.
pubmed.ncbi.nlm.nih.gov
The outer mitochondrial membrane (OMM) hosts a variety of proteins such as import machineries, enzymes, fission and fusion factors, and pore proteins. In Saccharomyces cerevisiae, the MIM complex,...
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