Pluchino lab - Regenerative Neuroimmunology
@Pluchinolab
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Developing experimental molecular medicines for chronic inflammatory diseases of the brain. 🇬🇧🇺🇸🇮🇹🇫🇷🇿🇦🇭🇰🇺🇦 🦋 Bluesky @pluchinolab.bsky.social
Cambridge, UK
Joined September 2011
🚀 Excited to see @BristenaIonescu PhD project, with co-first author @Telencephale, featured on the cover of @CellStemCell - Cholesterol-fuelled neurotoxic senescent PMS iNSCs and its pharmacological rescue is a major leap forward! 🎉 (link
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Brain-wide representations of prior information in mouse decision-making | Nature
nature.com
Nature - Brain-wide recordings in mice reveal that prior expectations are distributed through recurrent loops across all levels of cortical and subcortical processing.
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A brain-wide map of neural activity during complex behaviour | Nature
nature.com
Nature - The International Brain Laboratory presents a brain-wide electrophysiological map obtained from pooling data from 12 laboratories that performed the same standardized perceptual...
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RT @RealTalkMS_jon: Last week, the UAE became the first country in the world to approve Tolebrutinib for adults wit….
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Whole-genome single-cell multimodal history tracing to reveal cell identity transition
biorxiv.org
Advances in single-cell sequencing have deepened our understanding of cellular identities. However, because they inherently capture only static snapshots, after which no further observations are...
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Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action | Journal of Experimental Medicine | Rockefeller University Press
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Metformin alters mitochondria-related metabolism and enhances human oligodendrocyte function
nature.com
Nature Communications - Metformin is under clinical trial for brain neuroprotection but how it may work is poorly understood. Here, the authors show that metformin helps myelin formation by human...
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Cytoskeletal control in adult microglia is essential to restore neurodevelopmental synaptic and cognitive deficits
science.org
Microglial actin cytoskeletal dysregulation links excessive synaptic elimination to memory loss in neurodevelopmental conditions.
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Proinflammatory Effect of Mesenchymal Stem Cells.From Patients With Multiple Sclerosis
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Mitochondria structurally remodel near synapses to fuel the sustained energy demands of plasticity
biorxiv.org
The brain is a metabolically demanding organ as it orchestrates and stabilizes neuronal network activity through plasticity. This mechanism imposes enormous and prolonged energetic demands at...
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Follicular regulatory T cells promote experimental autoimmune encephalomyelitis by supporting B cell egress from germinal centers
science.org
Follicular regulatory T cells promote B cell–mediated experimental neuroinflammation and are associated with MS activity.
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RT @MitoPsychoBio: Some mitochondria puff out their content into the cytoplasm, exhibiting localized membrane distentions. This may contrib….
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Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human cortical organoid microphysiological systems
science.org
Monocytes from Alzheimer’s disease patients induce disease phenotypes in human cortical organoid microphysiological systems.
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Interferons in health and disease
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Mitochondrial transfer | Nature Metabolism
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Mitochondrial activity tunes nociceptor resilience to excitotoxicity.
cell.com
Excitation enables neuronal function; however, overexcitation and calcium overload can be deadly. This study reveals a cellular resilience program in which reduced expression of electron transport...
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LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development
cell.com
Adami et al. demonstrate that evolutionarily young L1s are expressed in human pluripotent stem cells and are dynamically regulated throughout neural differentiation. The study examines the role of...
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Neuroprotective mechanisms of exercise and the importance of fitness for healthy brain ageing - The Lancet
thelancet.com
Ageing is a scientifically fascinating and complex biological occurrence characterised by morphological and functional changes due to accumulated molecular and cellular damage impairing tissue and...
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Metabolic remodelling produces fumarate via the aspartate–argininosuccinate shunt in macrophages as an antiviral defence | Nature Microbiology
nature.com
Nature Microbiology - Viral infection diverts metabolic flux from the urea and TCA cycles to the ASS1-driven AAS shunt for fumarate production. Accumulated fumarate boosts IFNβ production and...
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