Pluchino lab - Regenerative Neuroimmunology
@Pluchinolab
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Developing experimental molecular medicines for chronic inflammatory diseases of the brain. 🇬🇧🇺🇸🇮🇹🇫🇷🇿🇦🇭🇰🇺🇦 🦋 Bluesky @pluchinolab.bsky.social
Cambridge, UK
Joined September 2011
Delighted to see this out in @NeuroCellPress!!! Together with @BeermanHSCaging (& many other friends) we identify disease-associated radial glia-like cells (#DARGs) that fuel #inflammation and #neurodegeneration in #progressiveMS
https://t.co/So70FSUKrh
cell.com
Park, Nicaise, Tsitsipatis, and colleagues discover transcriptional and epigenetic markers in human PMS iNSCs and fibroblasts that may underlie their senescent and inflammatory state. Novel DARGs...
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Fragmentation signatures in cancer patients resemble those of patients with vascular or autoimmune diseases
pnas.org
Multiple case-controlled studies have shown that analyzing fragmentation patterns in plasma cell-free DNA (cfDNA) can distinguish individuals with ...
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Diverse somatic genomic alterations in single neurons in chronic traumatic encephalopathy | Science
science.org
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease linked to exposure to repetitive head impacts (RHI), yet little is known about its pathogenesis. Applying two single-cell...
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How genetically encoded sensors have lit up neuroscience
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A spatial transcriptomic atlas of autism-associated genes identifies convergence in the developing human thalamus https://t.co/tQsCsQtAAB
biorxiv.org
Autism is a highly heritable neurodevelopmental condition that manifests across a wide phenotypic spectrum. Rare and de novo loss-of-function mutations strongly predispose to autism and co-occurring...
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Watson – who won the Nobel Prize for his role in divining the structure of DNA; was instrumental in initiating and propelling the Human Genome Project; and who became notorious for his history of racist and sexist comments – has died at 97 Read the full story:
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James D. Watson, Co-Discoverer of the Structure of DNA, Is Dead at 97 - The New York Times
nytimes.com
His decoding of the blueprint for life with Francis H.C. Crick made him one of the most important scientists of the 20th century. He wrote a celebrated memoir and later ignited an uproar with racist...
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BREAKING: James Watson, who helped discover the structure of DNA, has died at 97.
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Today CZI is announcing an unprecedented new scientific initiative to build the future of AI-powered biology. I am joining CZI to lead this initiative as Head of Science, and the EvolutionaryScale team is joining forces with Biohub. This is the first large scale scientific
biohub.org
The large-scale scientific effort combines frontier AI with frontier biology to accelerate discovery and solve disease.
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It is with sadness that we acknowledge the passing of Dr. James Watson, Nobel prize-winning scientist and former Director and President of CSHL. We extend our sincere condolences to his wife Liz and family during this difficult time. We recognize Dr. Watson’s incredible
cshl.edu
Jim Watson made many contributions to science, education, public service, and especially Cold Spring Harbor Laboratory (CSHL). As a scientist, his and Francis Crick’s determination of the structure...
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Beautiful talk from @SohailTavazoie at #SITC25! The intersection between neuroscience and cancer is fascinating, and particularly enjoyed the reminder that nerves in cancer were identified in @JExpMed in 1897! 🧐 #JEMlegacy
https://t.co/0NhxTG40np
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Human iPSC-Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer's Disease https://t.co/C1xAC5tjws
advanced.onlinelibrary.wiley.com
Short-term intravenous treatments with iPSC-derived mononuclear phagocytes (iMPs) improve cognitive decline and neural health in two mouse models of aging and in the 5xFAD mouse model of Alzheimer's...
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Lymphoid gene expression supports neuroprotective microglia function https://t.co/xjzRoAGS24
nature.com
Nature - PU.1low CD28-expressing microglia may act as suppressive cells in Alzheimer’s disease, mitigating its progression by reducing neuroinflammation and amyloid plaque load, indicating...
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A probabilistic histological atlas of the human brain for MRI segmentation https://t.co/FqYrCmTTcS
nature.com
Nature - NextBrain is an open source, probabilistic atlas of the entire human brain, assembled using artificial-intelligence-enabled registration and segmentation methods to reconstruct the...
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Molecular profiling of brain endothelial cell to astrocyte endfoot communication in mouse and human https://t.co/bBbIaM2n6r
nature.com
Nature Communications - Deciphering body-brain communication pathways is key to a deeper understanding of brain physiology and pathology. Here, the authors define the astrocyte endfoot proteome and...
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Developmental maps of the brain trace when cell types emerge https://t.co/d48wwdrBpN
nature.com
Nature - A large consortium of researchers has mapped how brain cells establish diverse identities throughout neurodevelopment and across species.
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Spatial dynamics of brain development and neuroinflammation https://t.co/9z8VYax29q
nature.com
Nature - A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.
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Epigenetic control of microglial developmental milestones from proliferative progenitors to efficient phagocytes
biorxiv.org
Early immune perturbations increase the risk of neurodegenerative and neurodevelopmental disorders, yet the mechanisms underlying the maturation of microglia, the resident immune cells of the brain...
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Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology https://t.co/Si5jHQwJ73
nature.com
Nature Metabolism - Barnett et al. disentangle the differential contribution of mitochondrial complex I- and complex III-derived ROS to astrocytic function, with CIII-derived ROS being a major...
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⚠️SAVE THE DATE⚠️ 🧠CAJAL CONFERENCE 2026 📍Cádiz, April 15–17 “Novel Insights into Brain Energy Metabolism in Health and Disease” Join an outstanding lineup of keynote speakers!👇🏻
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Super mitochondria-enriched extracellular vesicles enable enhanced mitochondria transfer
nature.com
Nature Communications - In mitochondria transplantation, the limited activity and yield of mitochondria constrain their clinical application for mitochondrial diseases. Here, authors develop a...
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