1/6 🚀 Delighted to see our review out online in Nature Reviews Bioengineering: CRISPR–Cas therapies targeting bacteria. Read:

Massive effort lead by the amazing @FabBenz to discuss the present and future of CRISPR-based antimicrobials ⚡

CRISPR–Cas therapies targeting bacteria https://t.co/Ug3IH6elQu

ps this is my last post on X — you can find me on 💙 under fabbenz for plasmid eco-evo and CRISPRy subjects

6/6 🙏 Huge thanks to co-authors @BeatrizBeamud @RaphaelLaurenceau @amandinemairee @duportet @AntoineDecrulle & @dbikard. 👏 Shout-out to the academics pushing the boundaries and to innovators at @sniprbiome , @LocusBio , @EligoBio and others turning concepts into clinics

5/6 – Clinical opportunities 👩‍⚕️ First-in-human trials already show safety and efficacy—proof CRISPR therapeutics can work in humans!

4/6 – The big hurdles 🛡️ Bacterial defences — restriction–modification systems, anti-CRISPRs and mutational escape — and how to bypass them

3/6 – In-situ delivery 🚚 Engineered phages, conjugative plasmids & more — pros, cons, host range, cargo size and manufacturability. No one-size-fits-all!

2/6 – CRISPR-Cas strategies 🧰 Toolbox & design considerations to eliminate bacteria or their plasmids — and to engineer microbes in situ

Two Postdocs (Lausanne, Switzerland) Bacterial genomics in the context of evolutionary epidemiology, with potential projects including antibiotic resistance, HGT and plasmid dynamics. with @sonjaklehtinen at University of Lausanne More details:

Plasmid Biologists ‼️ ⚠️4 days left ⚠️ to sign up to join the #ISPB Virtual Seminar Series and submit your abstract for a talk. See you there 💥

The honor of being a 'Pasteurian' does not pay rent, certainly not in Paris… Fingers crossed for today's negotiations with @institutpasteur

For the past two years, we have been working on a novel approach to identify origins of transfer by conjugation in plasmids from any bacterial species. We are thrilled to see this work now published in @NatureMicrobiol after thorough peer review! https://t.co/TpTxRy7jjd

Fantastic PhD Opportunity on plasmid-phage interactions in Manchester with @c_igler and Mike Brockhurst👇also: the time in Germany would be spent in my lab

Make sure you don't miss it! 🤓

Should I stay or should I go? 🎶 In a new opinion piece, @c_igler, Andrina Bernhard and I discuss how conjugative plasmids and temperate bacteriophages balance vertical and horizontal transmission: https://t.co/ZEqTzsgDiV Our framework illuminates many sides of MGE biology (1/7)

1/8. 𝐧𝐜𝐑𝐍𝐀𝐬 often fly under the radar... but they're vital in bacteria-phage conflicts & beyond. Curious 𝙬𝙝𝙮!? 🤔 Here, we dive into their immune roles, plasticity, and discuss their hidden potential! 🧬🚀 🔗: https://t.co/XI5VANrMrI

Meet The Shielded Plasmid🛡️🧬 Our new @Nature paper reveals how plasmids outsmart bacterial defenses during conjugation. It's all about being in the right place at the right time! The positioning of anti-defense genes boosts transfer efficiency🧵(1/7) https://t.co/6n8brUx1PU

We are hiring! 1 PhD position available within our newly-funded @ERC_Research project #PHAGEPRO @LMU_Muenchen. We are looking for a candidate with a strong background in bioinformatics! ChatGPT-generated applications will not be considered. Watch👇to learn more about the project

So glad to see this out! It was definitely a labor of love, but it has become my new blueprint of how I think about AMR evolution. We aimed to highlight how much we've learnt as a field, and especially, how much we still *don't* know 1/4