fabienne.benz
@FabBenz
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Working on the spread of antibiotic-resistance plasmids and the role of plasmid-encoded CRISPR-Cas currently postdoc @institutpasteur previously phd @ETH
Paris, France
Joined May 2019
1/6 🚀 Delighted to see our review out online in Nature Reviews Bioengineering: CRISPR–Cas therapies targeting bacteria. Read:
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RT @BeatrizBeamud: Massive effort lead by the amazing @FabBenz to discuss the present and future of CRISPR-based antimicrobials ⚡.
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ps.this is my last post on X — you can find me on 💙 under fabbenz for plasmid eco-evo and CRISPRy subjects.
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6/6.🙏 Huge thanks to co-authors @BeatrizBeamud @RaphaelLaurenceau @amandinemairee @duportet @AntoineDecrulle & @dbikard. 👏 Shout-out to the academics pushing the boundaries and to innovators at @sniprbiome , @LocusBio , @EligoBio and others turning concepts into clinics.
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5/6 – Clinical opportunities. 👩⚕️ First-in-human trials already show safety and efficacy—proof CRISPR therapeutics can work in humans!.
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4/6 – The big hurdles.🛡️ Bacterial defences — restriction–modification systems, anti-CRISPRs and mutational escape — and how to bypass them
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3/6 – In-situ delivery.🚚 Engineered phages, conjugative plasmids & more — pros, cons, host range, cargo size and manufacturability. No one-size-fits-all!
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2/6 – CRISPR-Cas strategies.🧰 Toolbox & design considerations to eliminate bacteria or their plasmids — and to engineer microbes in situ
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Plasmid Biologists ‼️. ⚠️4 days left ⚠️ to sign up to join the #ISPB Virtual Seminar Series and submit your abstract for a talk. See you there 💥.
📢 Can’t wait until the 2026 meeting to dive deeper into plasmids? . Join the ISPB Virtual Seminars Series, an exciting initiative aimed at strengthening our community in 2025! 🤓. 📅 Registration and abstract submission open until 20th January: .
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The honor of being a 'Pasteurian' does not pay rent, certainly not in Paris… . Fingers crossed for today's negotiations with @institutpasteur
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RT @M_AresArroyo: For the past two years, we have been working on a novel approach to identify origins of transfer by conjugation in plasmi….
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RT @CCWendling: Fantastic PhD Opportunity on plasmid-phage interactions in Manchester with @c_igler and Mike Brockhurst👇also: the time in G….
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RT @Jana_Huisman: Should I stay or should I go? 🎶.In a new opinion piece, @c_igler, Andrina Bernhard and I discuss how conjugative plasmids….
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RT @rafapinilla92: 1/8. 𝐧𝐜𝐑𝐍𝐀𝐬 often fly under the radar. but they're vital in bacteria-phage conflicts & beyond. Curious 𝙬𝙝𝙮!? 🤔. Here,….
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RT @BruriaSamuel: Meet The Shielded Plasmid🛡️🧬. Our new @Nature paper reveals how plasmids outsmart bacterial defenses during conjugation.….
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RT @CCWendling: We are hiring! 1 PhD position available within our newly-funded @ERC_Research project.#PHAGEPRO @LMU_Muenchen. We are looki….
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RT @Celia_Sqe: So glad to see this out!. It was definitely a labor of love, but it has become my new blueprint of how I think about AMR evo….
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